|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Advances in the diagnosis and management of acute retinal necrosis显示文摘Acute retinal necrosis(ARN)is a devastating syndrome characterized by panuveitis,retinal necrosis,and a high rate of retinal detachment that may result in poor visual outcomes if not promptly diagnosed and treated.ARN is most commonly caused by viruses within the herpesvirus family.Etiologies include varicella-zoster virus,herpes simplex virus,and cytomegalovirus,and may be promptly diagnosed by polymerase chain reaction testing of aqueous or vitreous fluid.The true incidence of ARN is not known due to its rarity;as a result,clinical treatment is often guided by retrospective case series,case reports,and expert opinion.Standard of care has evolved over time but currently includes a combination of systemic and intravitreal antiviral in conjunction with topical or oral steroids and surgical therapy as needed.Combination therapy may reduce the rate of severe vision loss and increase the rate of visual acuity gain,although further studies are needed in this area.In particular for patients with mild to moderate disease,combination therapy may reduce the rate of retinal detachment.Adjunctive therapies including oral corticosteroid and prophylactic laser barricade are incompletely studied,but corticosteroid in particular,may reduce inflammation,which also is involved in the severe disease pathogenesis observed in ARN.This review discusses the advances in diagnosis and treatment of ARN,including management with combination antiviral medication and surgical interventions. | Casey L.Anthony J.Clay Bavinger Steven Yeh | 2020 | Annals of Eye Science2020，，3： | 2 |
| 2 | Cytomegalovirus retinitis in the highly active anti-retroviral therapy era显示文摘Cytomegalovirus(CMV)retinitis is an opportunistic infection that has traditionally affected those who have HIV/AIDS or immunosuppressed individuals.CMV retinitis previously infected one-third of AIDS patients in the pre-highly active antiretroviral therapy(HAART)era,but since HAART,Western countries have seen an 80%decrease in the incidence of the disease.More recently,CMV retinitis has been reported in patients who are immunosuppressed,often due to chemotherapy or immunomodulatory medications.The diagnosis of CMV retinitis is often suspected based on clinical findings,with polymerase chain reaction for confirmation of CMV,especially in atypical cases.Highly active antiretroviral therapy and anti-CMV medications(systemic or local)remain the mainstay of treatment.However,for those who are not responsive to HAART,CMV retinitis remains a challenge,and can still lead to significant vision loss.Moreover,a regimen of anti-CMV medications can sometimes lead to viral resistance or organ toxicity.Complications such as immune recovery retinitis and rhegmatogenous retinal detachments continue to threaten the vision of patients who develop CMV retinitis.These complications can arise following initiation of treatment or if patients show disease progression.Proper vision screening for CMV retinitis in immunosuppressed patients at-risk is necessary for early detection and treatment. | Ifeoma N.Ude Steven Yeh Jessica G.Shantha | 2022 | Annals of Eye Science2022，，1： | 1 |
| 3 | Composite pleomorphic xanthoastrocytoma-ganglioglioma presenting as a suprasellar mass:case report显示文摘 | Yeh DJ Hessler RB Stevens EA | 2003 | Neurosurgery2003，52，6： | 1 |
| 4 | Treatment of atlantoaxial instability in pediatric patients 显示文摘 | Rahimi SY Stevens EA Yeh D J | 2003 | Neurosurg Focus2003，15，6： | 1 |
| 5 | Update on biologic therapies for juvenile idiopathic arthritis-associated uveitis显示文摘Juvenile idiopathic arthritis(JIA)is the most common rheumatic disease of childhood,and juvenile idiopathic associated uveitis(JIA-U)is the most frequently noted extra-articular manifestation.JIA-U can present asymptomatically and lead to ocular complications,so regular screening and monitoring are needed to prevent potentially sight-threatening sequelae.Topical glucocorticoids such as prednisolone acetate are usually the first line of treatment for anterior uveitis associated with JIA-U,but long-term use may be associated with cataract,ocular hypertension and glaucoma.Disease modifying anti-rheumatic drugs(DMARDs)such as methotrexate allow tapering of the corticosteroids to prevent long-term complications.Biologic therapies have been increasingly used as targeted therapies for JIA-U,particularly monoclonal antibodies targeting the proinflammatory cytokine TNF-αsuch as adalimumab and infliximab.One recent,multicenter,prospective,randomized clinical trial provided evidence of the efficacy of adalimumab with methotrexate for JIA-U compared to methotrexate alone.Another clinical trial studying the interleukin-6 inhibitor tocilizumab for JIA-U showed promise in tapering topical corticosteroids.Additionally,JAK inhibitors are emerging biologic therapies for JIA-U in patients refractory to TNF-αinhibitors,with a clinical trial assessing the efficacy of baricitinib for JIA-U underway.While clinical trials on these novel biologics are limited,further investigation of these agents may provide additional therapeutic options for JIA-U. | Joanne Thomas Sanjana Kuthyar Jessica G.Shantha Sheila T.Angeles-Han Steven Yeh | 2021 | Annals of Eye Science2021，，2： | 1 |
| 6 | Pediatric uveitis:EYE-Q and metrics beyond visual acuity显示文摘Pediatric uveitis is an inflammatory ocular disease that can lead to sight-threatening complications.Pediatric patients have distinct challenges in the diagnosis and management of uveitis,secondary to difficulties in performing ophthalmic examinations in young children,delayed diagnosis due to lack of adherence with recommended screening schedules,medication side-effects,and increased burden of disease into adulthood.Measurement of outcomes in pediatric uveitis has traditionally relied upon the ophthalmic examination and general quality of life(QOL)measures.However,the ophthalmic examination does not take into account the impact of uveitis on a child’s QOL and general QOL measures do not adequately assess the specific effects of vision.Several vision-related quality of life(VR-QOL)instruments have been used to measure outcomes in both adults and children including:the National Eye Institute Visual Function Questionnaire(NEI VFQ-25),Vision-related Quality of Life of Children and Young People(VQoL_CYP),the Children’s Visual Function Questionnaire(CVFQ),and the Effect of Youngsters’Eyesight on Quality of Life(EYE-Q).However,the NEI VFQ-25 is not a valid or applicable measure in children,and the VQoL_CYP and CVFQ are not uveitis specific and may not characterize disease specific burdens.The EYE-Q is the only uveitis-specific pediatric questionnaire that measures visual functioning and VR-QOL in 5-18 years old children and adolescents with uveitis.It has been shown to be a valid and reliable assessment tool in several cohorts of children with uveitis.A comprehensive assessment of the impact of uveitis on a child that includes a vision-specific measure,such as the EYE-Q,allows for better understanding of the true burden of uveitis in children.For this review,we describe traditional outcome measures in uveitis studies,general QOL measures and vision-specific measures in adults and in children. | Joseph M.McDonald Steven Yeh Sheila T.Angeles-Han | 2020 | Annals of Eye Science2020，，2： | 1 |
| 7 | Induction of castration by immunization of male dogs with recombination gonadotropin-releasing hormone (GnRH-I) -canine distemper virus (CDV) T helper cell epitope p35 显示文摘 | Mi-Jeong Jung Young-Chan Moon Ik-Hyun Cho Jung-Yong Yeh Sun-Eui Kim Wha-Seok Chang Seung-Young Park Chang-Seon Song Hwi-Yool Kim Keun-Kyu Park Steven McOrist | 2005 | Veterinary Science2005，6，1： | 1 |
| 8 | Innovations in the diagnosis and management of uveitis: promising research to address unmet patient needs显示文摘Uveitis,or inflammation of the uveal tissues(iris,ciliary body and the choroid),and its contiguous structures,can lead to severe visual impairment and is among the leading causes of vision impairment worldwide(1).In clinical practice,specialists in uveitis and ocular immunology are called upon to manage a range of uveitis syndromes-infectious disease,noninfectious autoimmune conditions,and masquerade syndromes such as lymphoma.Moreover,ophthalmologists of all subspecialties(i.e.,medical and surgical retina,corneal surgeons,orbital/oculoplastic surgeons,and comprehensive ophthalmologists)are called upon to manage uveitis syndromes,emphasizing clear importance to understanding common uveitis syndromes,diagnostic workups,and the state-of-the-art in uveitis and ocular inflammation care. | Steven Yeh Ye Huang Joanne Thomas | 2022 | Annals of Eye Science2022，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员