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| 1 | An erosional hiatus in Chinese loess sequences revealed by closely spaced optical dating显示文摘Chinese loess deposits are some of the best continental records of palaeoclimatic and pa- laeoenvironmental changes in the late Cenozoic. Many investigations have shown that the long-time climate variations recorded by the loess-paleosol sequences can be correlated with global environ- mental changes. However,there are still some foundational questions concerning loess deposition that are not well answered,casting uncertainty on many previous conclusions,especially high-resolu- tion palaeoclimatic records. In this study,three typical loess-paleosol sections spanning the last glacial cy- cle were closely sampled for optically stimulated lu- minescence (OSL) dating and palaeoclimate inter- pretation along a northwest-southeast transect in Chinese Loess Plateau. Results show that there is a 4-5 ka hiatus in the typical loess deposits,and as a consequence suggests that the loess record is not continuous over millennial time scales. As such,pre- vious conclusions on climatic and environmental changes at millennial-centennial time scale,recon- structed through the loess record,should be reinves- tigated. The erosional hiatus may be forced by a pe- riod with strengthened East Asian winter monsoon and the less vegetation cover in the investigated sites. | LU Huayu Thomas Stevens YI Shuangwen SUN Xuefeng | 2006 | Chinese Science Bulletin2006，51，18： | 17 |
| 2 | On-the-fly active learning of interpretable Bayesian force fields for atomistic rare events显示文摘Machine learned force fields typically require manual construction of training sets consisting of thousands of first principles calculations,which can result in low training efficiency and unpredictable errors when applied to structures not represented in the training set of the model.This severely limits the practical application of these models in systems with dynamics governed by important rare events,such as chemical reactions and diffusion.We present an adaptive Bayesian inference method for automating the training of interpretable,low-dimensional,and multi-element interatomic force fields using structures drawn on the fly from molecular dynamics simulations.Within an active learning framework,the internal uncertainty of a Gaussian process regression model is used to decide whether to accept the model prediction or to perform a first principles calculation to augment the training set of the model.The method is applied to a range of single-and multi-element systems and shown to achieve a favorable balance of accuracy and computational efficiency,while requiring a minimal amount of ab initio training data.We provide a fully opensource implementation of our method,as well as a procedure to map trained models to computationally efficient tabulated force fields. | Jonathan Vandermause Steven B.Torrisi Simon Batzner Yu Xie Lixin Sun Alexie M.Kolpak Boris Kozinsky | 2020 | npj Computational Materials2020，，1： | 17 |
| 3 | A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response显示文摘病毒的 RNA 的识别由 cytosolic 传感器 retinoic 组织酸可诱导的基因 --(RIG-I ) 我导致表明与类型的产生达到顶点的串联的激活我干扰素(IFN ) 抗病毒的反应。对病毒的病原体的抗病毒、煽动性的回答的发作要求表明改编者, kinases 和 transcriptional 蛋白质到 mitochondrial 的调整空间与时间的招募抗病毒的发信号蛋白质(MAVS ) 。我们以前示威了 serine/threonine kinase IKKε被招募到 MAVS 后面的仙台或小囊的口炎病毒(VSV ) 感染的 C 终端区域,在 Lys500 由 MAVS 的连接 Lys63 的 polyubiquitination 调停了,导致下游的 IFN 发信号的抑制(Paz 等,摩尔房间 Biol, 2009 ) 。在这研究,我们证明 MAVS 的 C 终点在 MAVS 的 aa450-468 区域怀有一个新奇 TRAF3 有约束力的地点。一个一致交往 TRAF 主题(提姆) , 455-PEENEY-460,在这以内,地点为 TRAF3 绑定和 IFN 抗病毒的反应基因的激活被要求,而 TIM 的变化消除 TRAF3 绑定和下游的 IFN 反应。有表示 MAVS 的一个变异提姆的版本的构造的 MAVS −/− 老鼠胚胎成纤维细胞的宪法没能恢复抗病毒的反应或块 VSV 复制,而野类型的 MAVS 重新组成 VSV 复制的抗病毒的抑制。而且, IKKε 的招募;到在经由 Lys500 的 MAVS 的一个邻近的 C 终端地点(aa 468-540 ) , ubiquitination 减少了 TRAF3 绑定和蛋白质稳定性,因此贡献 IKKε调停 IFN 反应关机。这研究证明 MAVS 怀有功能的 C 终端参予 IFN 抗病毒的反应的积极、否定的规定的 TRAF3 有约束力的地点。 | Suzanne Paz Myriam Vilasco Steven J Werden Meztli Arguello Deshanthe Joseph-Pillai Tiejun Zhao Thi Lien-Anh Nguyen Qiang Sun Eliane F Meurs Rongtuan Lin John Hiscott | 2011 | Cell Research2011，21，6： | 12 |
| 4 | ζ-Carotene Isomerase Suppresses Tillering in Rice through the Coordinated Biosynthesis of Strigolactone and Abscisic Acid显示文摘Rice tillering is an important agronomic trait affecting grain yield.Here,we identified a high-tillering mutant tillering20(t20),which could be restored to the wild type by treatment with the strigolactone(SL)analog rac-GR24.T20 encodes a chloroplast ζ-carotene isomerase(Z-ISO),which is involved in the biosynthesis of ca-rotenoids and their metabolites,SL and abscisic acid(ABA).The t20 mutant has reduced SL and ABA,raising the question of how SL and ABA biosynthesis is coordinated,and whether they have overlapping functions in tillering.We discovered that rac-GR24 stimulated T20 expression and enhanced all-trans-p-carotene biosynthesis.Importantly,rac-GR24 also stimulated expression of Oryza sativa 9-CIS-EPOXY-CAROTENOID DIOXYGENASE 1(OsNCED1)through induction of Oryza sativa HOMEOBOX12(0sHOX12),promoting ABA biosynthesis in shoot base.On the other hand,ABA treatment significantly repressed SL biosynthesis and the ABA biosynthetic mutants displayed elevated SL biosynthesis.ABA treatment reduced the number of basal tillers in both t20 and wild-type plants.Furthermore,while ABA-deficient mu-tants aba1 and aba2 had the same number of basal tillers as wild type,they had more unproductive upper tillers at maturity.This work demonstrates complex interactions in the biosynthesis of carotenoid,SLs and ABA,and reveals a role for ABA in the regulation of rice tillering. | Xue Liu Qingliang Hu Jijun Yan Kai Sun Yan Liang Meiru Jia Xiangbing Meng Shuang Fang Yiqin Wang Yanhui Jing Guifu Liu Dianxing Wu Chengcai Chu Steven M.Smith Jinfang Chu Yonghong Wang Jiayang Li Bing Wang | 2020 | Molecular Plant2020，13，12： | 11 |
| 5 | A Lunar-based Soft X-ray Imager(LSXI)for the Earth's magnetosphere显示文摘We propose to use the Moon as a platform to obtain a global view of Earth's magnetosphere by a Lunar-based Soft X-ray Imager(LSXI).LSXI is a wide field-of-view Soft X-ray telescope,which can obtain X-ray images of Earth's magnetosphere based on the solar wind charge exchange(SWCX)X-ray emission.Global perspective is crucial to understand the overall interaction of the solar wind with magnetosphere.LSXI is capable of continuously monitoring the evolution of geospace conditions under the impact of the solar wind by simultaneous observation of the bow shock,magnetosheath,magnetopause and cusps for the first time.This proposal is answering the call for the Chinese Lunar Exploration Program Phase IV. | Yihong GUO Chi WANG Fei WEI Tianran SUN Xizheng YU Songwu PENG Graziella BRANDUARDI-RAYMONT Steven SEMBAY | 2021 | Science China Earth Sciences2021，64，7： | 5 |
| 6 | A Fusion Steganographic Algorithm Based on Faster R-CNN显示文摘The aim of information hiding is to embed the secret message in a normal cover media such as image,video,voice or text,and then the secret message is transmitted through the transmission of the cover media.The secret message should not be damaged on the process of the cover media.In order to ensure the invisibility of secret message,complex texture objects should be chosen for embedding information.In this paper,an approach which corresponds multiple steganographic algorithms to complex texture objects was presented for hiding secret message.Firstly,complex texture regions are selected based on a kind of objects detection algorithm.Secondly,three different steganographic methods were used to hide secret message into the selected block region.Experimental results show that the approach enhances the security and robustness. | Ruohan Meng Steven G.Rice Jin Wang Xingming Sun | 2018 | Computers, Materials & Continua2018，，4： | 4 |
| 7 | Deriving the magnetopause position from wide field-of-view soft X-ray imager simulation显示文摘Imaging techniques provide essential information in astronomical and space physics studies.The Soft X-ray Imager(SXI)will obtain images of the Earth’s magnetosphere via the solar wind charge exchange process in a global view.However,it is a challenge to reconstruct its 3-D structures from the observed 2-D image(s).In this paper,a recently proposed method,Tangent Fitting Approach(TFA),is validated to reconstruct the large-scale magnetopause from a single X-ray image obtained by instrument simulation.It is revealed that the large-scale magnetopause under a medium solar wind number density can be well reconstructed,although the locations of maximum X-ray photon counts are scattered in the image due to instrumental effects and diffusive sky background.Higher solar wind number density leads to stronger signals and further leads to better reconstruction results.For lower solar wind density,the X-ray maximum photon counts may not be identified from the SXI simulations,preprocessing of the images shall be considered before applying TFA.Furthermore,the subsolar magnetopause can be well derived when the satellite is on the dayside orbits. | Yihong GUO Tianran SUN Chi WANG Steven SEMBAY | 2022 | Science China Earth Sciences2022，65，8： | 4 |
| 8 | Towards high-power, high-coherence, integrated photonic mm Wave platform with microcavity solitons显示文摘Millimetre-wave(mmWave)technology continues to draw great interest due to its broad applications in wireless communications,radar,and spectroscopy.Compared to pure electronic solutions,photonic-based mmWave generation provides wide bandwidth,low power dissipation,and remoting through low-loss fibres.However,at high frequencies,two major challenges exist for the photonic system:the power roll-off of the photodiode,and the large signal linewidth derived directly from the lasers.Here,we demonstrate a new photonic mmWave platform combining integrated microresonator solitons and high-speed photodiodes to address the challenges in both power and coherence.The solitons,being inherently mode-locked,are measured to provide 5.8 dB additional gain through constructive interference among mmWave beatnotes,and the absolute mmWave power approaches the theoretical limit of conventional heterodyne detection at 100 GHz.In our free-running system,the soliton is capable of reducing the mmWave linewidth by two orders of magnitude from that of the pump laser.Our work leverages microresonator solitons and high-speed modified uni-traveling carrier photodiodes to provide a viable path to chip-scale,high-power,low-noise,high-frequency sources for mmWave applications. | Beichen Wang Jesse SMorgan Keye Sun Mandana Jahanbozorgi Zijiao Yang Madison Woodson Steven Estrella Andreas Beling Xu Yi | 2021 | Light(Science & Applications)2021，10，1： | 3 |
| 9 | Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN显示文摘 | Zvi G. Fridlender Jing Sun Samuel Kim Veena Kapoor Guanjun Cheng Leona Ling G. Scott Worthen Steven M. Albelda | 2009 | Cancer Cell2009，，： | 2 |
| 10 | Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)显示文摘 | Fiona McPhee Amy K. Sheaffer Jacques Friborg Dennis Hernandez Paul Falk Guangzhi Zhai Steven Levine Susan Chaniewski Fei Yu Diana Barry Chaoqun Chen Min S. Lee Kathy Mosure Li-Qiang Sun Michael Sinz Nicholas A. Meanwell Richard J. Colonno Jay Knipe Paul S | 2012 | Antimicrobial Agents and Chemotherapy2012，，10： | 2 |
| 11 | Outsourcing CO2 within China显示文摘 | Kuishuang Feng Steven J. Davis Laixiang Sun Xin Li Dabo Guan Weidong Liu Zhu Liu Klaus Hubacek | 2013 | Proceedings of the National Academy of Sciences2013，，28： | 2 |
| 12 | Hepatitis C Infection and Related Factors in Hemodialysis Patients in China: Systematic Review and Meta-Analysis显示文摘 | Jinghua Sun Rongbin Yu Bei Zhu Jianqing Wu Steven Larsen Weihong Zhao | 2009 | Renal Failure2009，，7： | 2 |
| 13 | B1 Sequence-based real-time quantitative PCR:a sensitive method for direct measurement of mouse plasma DNA levels after gamma irradiation 显示文摘 | Zhang H Steven B Sun W | 2009 | Int J Radiation Oncology Biol Phys2009，74，5： | 1 |
| 14 | Evolution of subcontinental lithospheric mantle beneath eastern China: Re–Os isotopic evidence from mantle xenoliths in Paleozoic kimberlites and Mesozoic basalts显示文摘 | Hong-Fu Zhang Steven L. Goldstein Xin-Hua Zhou Min Sun Jian-Ping Zheng Yue Cai | 2008 | Contributions to Mineralogy and Petrology2008，，3： | 1 |
| 15 | Pulmonary eosinophilia is attenuated by early responding CD8 * memory T cells in a murine model of RSV vaccine-enhanced disease 显示文摘 | Stevens WW Sun J Castillo JP et ol | 2009 | Viral Im- munol2009，22，4： | 1 |
| 16 | Whole cell bioreporter application for rapid detection and evaluation of crude oil spill in seawater caused by Dalian oil tank explosion显示文摘 | Dayi Zhang Aizhong Ding Shuangchao Cui Cheng Hu Steven F. Thornton Junfeng Dou Yujiao Sun Wei E. Huang | 2012 | Water Research2012，，： | 1 |
| 17 | Microsatellitevariability and heterozygote excess in Elymus trachycauluspopulations from British Columbia in Canada显示文摘 | Stevens Laci Salomon Bj?rn Sun Genlou | 2007 | BiochemicalSystematics and Ecology2007，35，： | 1 |
| 18 | Survival of patients with BRCAl-assoeiated breast cancer diagnosed in an MRI-based surveillance program显示文摘 | Stormorken Christoffer Jonsrud Marit Muri Holmen Anne Irene Hagen Neal Clark Anita Sun Steven A Narod Lovise | 2013 | Breast cancer research and treatment2013，139，1： | 1 |
| 19 | Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis c virus显示文摘 | Hervé Lerat Masao Honda Michael R. Beard Kim Loesch Jiaren Sun Yan Yang Michiari Okuda Rainer Gosert Shu-Yuan Xiao Steven A. Weinman Stanley M. Lemon | 2002 | Gastroenterology2002，，2： | 1 |
| 20 | The Cys- teine protease domain of porcine reproductive and re- spiratory syndrome virus nonstructural protein 2 pos- sesses deubiquitinating and interferon antagonism functions 显示文摘 | SUN Z CHEN Z H STEVEN R L | 2010 | J Virol2010，84，15： | 1 |
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