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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 3 | Pathways of China's PM;air quality 2015–2060 in the context of carbon neutrality显示文摘Clean air policies in China have substantially reduced particulate matter(PM;) air pollution in recent years,primarily by curbing end-of-pipe emissions.However,reaching the level of the World Health Organization(WHO) guidelines may instead depend upon the air quality co-benefits of ambitious climate action.Here,we assess pathways of Chinese PM;air quality from 2015 to 2060 under a combination of scenarios that link global and Chinese climate mitigation pathways(i.e.global 2℃-and 1.5℃-pathways,National Determined Contributions(NDC) pledges and carbon neutrality goals) to local clean air policies.We find that China can achieve both its near-term climate goals(peak emissions) and PM;air quality annual standard(35 μg/m;) by 2030 by fulfilling its NDC pledges and continuing air pollution control policies.However,the benefits of end-of-pipe control reductions are mostly exhausted by 2030,and reducing PM;exposure of the majority of the Chinese population to below 10 μg/m;by 2060 will likely require more ambitious climate mitigation efforts such as China’ s carbon neutrality goals and global1.5℃-pathways.Our results thus highlight that China’s carbon neutrality goals will play a critical role in reducing air pollution exposure to the level of the WHO guidelines and protecting public health. | Jing Cheng Dan Tong Qiang Zhang Yang Liu Yu Lei Gang Yan Liu Yan Sha Yu Ryna Yiyun Cui Leon Clarke Guannan Geng Bo Zheng Xiaoye Zhang Steven JDavis Kebin He | 2021 | National Science Review2021，8，12： | 23 |
| 4 | Single-cell RNA-seq reveals the immune escape and drug resistance mechanisms of mantle cell lymphoma显示文摘Objective:Mantle cell lymphoma(MCL)is a rare subtype of non-Hodgkin lymphoma(NHL)with high heterogeneity and a high recurrence rate.How heterogenous cell populations contribute to relapse remains to be elucidated.Methods:We performed single cell RNA sequencing(scRNA-seq)on approximately 4,000 bone marrow cells sampled from one patient with multidrug resistant MCL.We identified 10 subpopulations comprising 4 malignant B cell subtypes,3 T cell subtypes,2 dendritic cell subtypes and 1 natural killer(NK)cell subtype.Subsequently,we identified cell markers,including a series of genes associated with immune escape and drug resistance.In addition,we explored the roles of these genes in the mechanism of immune escape and drug resistance,and we verified the expression imbalance and clinical prognostic potential by using GEO datasets including 211 MCL samples.Results:The major immune escape mechanisms of MCL included anti-perforin activity,decreased immunogenicity and direct inhibition of apoptosis and cell killing,as mediated by type I and II B cells.The drug resistance mechanisms of different cell clusters included drug metabolism,DNA damage repair,apoptosis and survival promotion.Type III B cells closely communicate with other cells.The key genes involved in the resistance mechanisms showed dysregulated expression and may have significant clinical prognostic value.Conclusion:This study investigated potential immune escape and drug resistance mechanisms in MCL.The results may guide individualized treatment and promote the development of therapeutic drugs. | Liang Wang Steven Mo Xin Li Yingzhi He Jing Yang | 2020 | Cancer Biology & Medicine2020，17，3： | 5 |
| 5 | The management of nonpigmented gallstones in children显示文摘 | Steven WB Sigmund HE Catharine R | | 0，，05： | 1 |
| 6 | Twelve-month safety and efficacy of low-dose mifepristone for uterine myomas显示文摘 | Steven HE | 2005 | Journal of Minimally Invasive Gynecology2005，，2005： | 1 |
| 7 | The water-soluble ionic composition of PM2.5 in Shanghai and Beijing, China显示文摘 | Xiaohong Yao Chak K. Chan Ming Fang Steven Cadle Tai Chan Patricia Mulawa Kebin He Boming Ye | 2002 | Atmospheric Environment2002，，26： | 1 |
| 8 | Should We Test for CYP2C9 Before Initiating Anticoagulant Therapy in Patients with Atrial Fibrillation显示文摘 | Mark HE Steven MG Jonathan R | 2009 | Gen Intern Med2009，5，24： | 1 |
| 9 | Epithelial Injury Induces Keratocyte Apoptosis: Hypothesized Role for the Interleukin-1 System in the Modulation of Corneal Tissue Organization and Wound Healing显示文摘 | STEVEN E. WILSON YU-GUANG HE JIAN WENG QIAN LI ALASDAIR W. McDOWALL MARK VITAL ERIC L. CHWANG | 1996 | Experimental Eye Research1996，，4： | 1 |
| 10 | Nitric oxide represses the Arabidopsis floral transi- tion 显示文摘 | He Y Tang RH Hao Y Stevens RD Cook CW AhnSM Jing L Yang Z Chen L Guo F | 2004 | Science2004，305，： | 1 |
| 11 | Brief Report: Phenotypic Rescue of Induced Pluripotent Stem Cell‐Derived Motoneurons of a Spinal Muscular Atrophy Patient显示文摘 | Tammy Chang Weiyan Zheng Walter Tsark Steven Bates He Huang Ren‐Jang Lin Jiing‐Kuan Yee | 2011 | STEM CELLS2011，，12： | 1 |
| 12 | Magnesium Intake and Incidence of Metabolic Syndrome Among Young Adults显示文摘 | Ka He Kiang Liu Martha L. Daviglus Steven J. Morris Catherine M. Loria Linda Van Horn David R. Jacobs Peter J. Savage | 2006 | Circulation2006，，13： | 1 |
| 13 | Prefrontal cortex: disorders and development显示文摘 | Stevens HE | 2010 | J Am Acad Child Adolesc Psychiatry2010，49，3： | 1 |
| 14 | Risk and resilience: early manipulation of macaque social experience and persistent behavioral and neurophysiological outcomes 显示文摘 | Stevens HE Leckman JF Coplan JD | 2009 | J Am Acad Child Adolesc Psychiatry2009，48，2： | 1 |
| 15 | Appendicitis in the child with a ventriculo-peritoneal shunt: a 30-year review显示文摘 | Sigmund HE Steven Miller James TR | 2006 | Journal of Pediatric Surgery2006，41，： | 1 |
| 16 | Vascular complication of neck space infection:case report and literature review显示文摘 | Stevens HE | 1990 | J Otolaryngol1990，19，： | 1 |
| 17 | Three‐dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement显示文摘 | Jinyuan Zhou He Zhu Michael Lim Lindsay Blair Alfredo Quinones‐Hinojosa Steven A. Messina Charles G. Eberhart Martin G. Pomper John Laterra Peter B. Barker Peter C.M. Zijl Jaishri O. Blakeley | 2013 | J Magn Reson Imaging2013，，5： | 1 |
| 18 | Increased Angiotensin II-Mediated Src Signaling via Epidermal Growth Factor Receptor Transactivation Is Associated With Decreased C-Terminal Src Kinase Activity in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats显示文摘 | Rhian M. Touyz Xiao-Hua Wu Gang He Steven Salomon Ernesto L. Schiffrin | | Hypertension: Journal of the American Heart Association0，，： | 1 |
| 19 | Assessing the environmental impacts of aircraft noise and emissions显示文摘 | Anuja Mahashabde Philip Wolfe Akshay Ashok Christopher Dorbian Qinxian He Alice Fan Stephen Lukachko Aleksandra Mozdzanowska Christoph Wollersheim Steven R.H. Barrett Maryalice Locke Ian A. Waitz | 2010 | Progress in Aerospace Sciences2010，，1： | 1 |
| 20 | Mechanical characteristics of individual multi-layer graphene-oxide sheets under direct tensile loading显示文摘 | Chao Wang Qingyu Peng Jianyang Wu Xiaodong He Liyong Tong Quantian Luo Jianjun Li Steven Moody Hongwei Liu Rongguo Wang Shanyi Du Yibin Li | 2014 | Carbon2014，，： | 1 |
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