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| 1 | 室间隔切除术:治疗梗阻性肥厚型心肌病的金标准显示文摘梗阻性肥厚型心肌病(HCM)间隔切除术的治疗方法几乎与HCM文献报道同时出现。现在越来越清楚的表明,间隔切除术是一种缓解流出道梗阻症状最可靠的治疗方法。间隔切除术在HCM治疗中地位的不断提高,主要是因为:(1)对梗阻的患病率及其影响认识更加清楚;(2)通过与酒精消融术的比较,使我们对该术式的认识更加清楚。下面我们介绍一下Mayo医院外科治疗HCM的经验。 | Joseph A Dearani Hartzell V Schaff Steve R Ommen | 2009 | 中华心血管病杂志2009，37，4： | 7 |
| 2 | Cancer and age related colonic crypt deficiencies in cytochrome c oxidase Ⅰ显示文摘AIM: To investigate whether defi ciency of expressionof cytochrome c oxidase I (CcOI) in colonic crypts is associated with colon cancer.METHODS: The pattern and level of expression of CcOI in non-neoplastic colonic crypts,and in dysplastic tissues,was assessed using standard immunohis-tochemical methods.Biopsies were obtained from individuals undergoing colonoscopies for screening purposes or for a medically indicated reason.Tissue samples were also obtained from surgical colonic resections.Samples from resections were taken from colonic mucosa 1 and 10 cm from tumors and from the tumors themselves.Samples were evaluated for frequency of crypts with reduced or absent expression of CcOI.In most crypts the loss was apparent throughout the entire crypt,while in a small minority the loss was segmental.The strong immunoreactivity using this monoclonal antibody makes the scoring unambiguous.The percent of crypts with reduced or absent expression of CcOI or (infrequent) segmented loss of expression was then calculated.Data analyses were performed using SPSS statistical package 17.0.RESULTS: The average frequency of CcOI deficient crypts (CcOI-DC) is low in individuals between 20 and 39 years of age,with 0.48% ± 0.40% CcOI-DC for women and 1.80% ± 0.35% for men.CcOI-DC increases after age 40 years,so that between the ages of 40 and 44 years the average frequency of CcOI- DC goes up to 5.89% ± 0.84% in women and 2.15% ± 1.27% in men.By 80-84 years of age,the average frequency of CcOI-DC goes up in women to 15.77% ± 0.97% and in men to 22.6% ± 0.65%.The increases in CcOI-DC from ages 40-44 years compared to 80-84 years in women and men are significantly different with P < 0.01.For women over age 60 years,deficiency of CcOI expression is greater in those women who have had a cancer in their colon.The frequency of CcOI-DC,measured in men,increased in tissues adjacent to colon cancer,being 4.03% ± 0.27% in individuals free of neoplasia in the age range 55-64 yearsand 14.13% ± 0.35% in resected histologically normal tissue of men with cancer in the same age range,P < 0.001.Similar signifi cant differences were noted in older age ranges.The frequency of CcOI-DC crypts in the cecum and sigmoid colon of an individual are signifi cantly correlated,with an R2 = 0.414 for women and R2 = 0.528 for men,P < 0.001.This suggests that the factors determining the level of CcOI deficiency act throughout the colon.Most defective crypts are in clusters of two or more,a likely consequence of crypt fission.In the non-neoplastic margins of cancers,crypts are frequently defi cient for CcOI,and such crypts may appear in large clusters,some containing more than 100 defi cient crypts.CcOI defi ciency is also apparent in colon cancers and sometimes involves a large section of the tumor.Overall,CcOI deficient cells can be visualized in segments of crypts,in whole crypts that increase in frequency with age,in crypts undergoing f ission,in clusters of crypts where the clusters increase in size with age,in increased frequency near tumors,in large clusters in the intimate margins of tumors,and in the tumors themselves.There is no clear dividing line between early stages that can be considered aspects of aging and later stages that can be considered aspects of the progression to cancer.This ambiguity may re ect a rather general situation leading to adult cancer where the early stages of cellular change appear to be relatively innocuous features of the aging process but over decades may evolve into malignancy.CONCLUSION: CcOI defi cient crypts increase in frequency with age,and clusters of defi cient crypts are associated with,and may give rise to,colon cancer. | Carol Bernstein Alexander Facista Huy Nguyen Beryl Zaitlin Nadia Hassounah Cristy Loustaunau Claire Margaret Payne Bhaskar Banerjee Steve Goldschmid V Liana Tsikitis Robert Krouse Harris Bernstein | 2010 | World Journal of Gastrointestinal Oncology2010，2，12： | 5 |
| 3 | B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma显示文摘到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式,导致在这些病人的增加的病态和住院。尽管 B 淋巴细胞可能通过 IgE 的生产加重气喘症状,这些房间可能也在对吸入的真菌的保护的反应是重要的。通过 cytokine 版本和 T 房间相互作用,这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。J H −/− 老鼠为抗体的重链部件缺乏 JH 基因,它为 B 房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于 B 淋巴细胞的角色的说明;然而, J H −/− 老鼠没被用来学习真菌的过敏症。在这研究,我们用曲霉属菌 fumigatus 检验了 B 淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的 BALB/c 和 J 暴露于的 H −/− 老鼠重复了真菌的暴露并且没在大航线附近在航线 hyperresponsiveness,全面肺的发炎或骨胶原免职发现差别。然而, Th2 类型 cytokines IL-4 和 IL-13 的层次显著地在 J 相对 BALB/c 控制的 H −/− 鼠标。由对比,煽动性的 cytokines IL-17A 和 IL-6 的层次显著地在 J H −/− 动物,并且有显著地更柔韧的航线嗜曙红血球过多和 neutrophilia 比在控制动物。一起拿,这些调查结果表明淋巴细胞帮助在肺的分隔空间调整 granulocytic 回答到真菌的暴露的那 B。 | Sumit Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam Jane M Schuh | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 4 | A framework for ranking of cloud computing services显示文摘 | SAURABH K G STEVE V RAJKUMAR B | | 0，，04： | 2 |
| 5 | Analysis of the efficacy and safety of excimer laser PTK in the treatment of corneal disease显示文摘 | Stephen J Zuckerman James V Aquavella Steve B Park | 1996 | Cornea1996，15，1： | 1 |
| 6 | Reduchon of Chloride Ion Interferencl in Chenineal Oxygen Demand (COD) Determinations Using Bismnth-based Adsorbents显示文摘 | BIKAS V STEVE W W SHELLEY J C | 1997 | Analytica Chimica Acta1997，357，12： | 1 |
| 7 | Characterization of nanocellulose-reinforced shape memory polyurethanes显示文摘 | Auad M L Contos V S Nutt Steve | 2008 | Poly Int2008，57，： | 1 |
| 8 | Aroclor 1254 disrupts liv-er glycogen metabolism and enhances acute stressor-mediated glycogenolysis in rainbow trout 显示文摘 | Steve W’Mathilakath M V | 2011 | CompBiochem Physiol Toxicol Pharmacol2011，154，3： | 1 |
| 9 | Hyaluronic acid production in Bacillus subtilis显示文摘 | Bill W Re'gine B Steve V D | | 0，，07： | 1 |
| 10 | Amyotrophic lateral sclerosis 显示文摘 | Matthew CK Steve V Benjamin CC | 2011 | Lancet2011，377，9769： | 1 |
| 11 | Structural evaluation of column-height controls at a toe-thru:,;t discovery, deep-water Niger Delta显示文摘 | Olga V Kostenko Steve J Naruk Willem Hack | 2008 | AAPG Bulletin2008，92，12： | 1 |
| 12 | The effect of rapid thermal processing (RTP) on TiN coatings deposited by PVD and the steel-turning performance of coated cemen- ted carbide 显示文摘 | Anthoy J Perry J N Steve J Bull Dmitri I P Peter C R Trevor F P Daniel E G James T John J V Robert E D Vladinmir R Alexey B M | 1999 | Surface and Coatings Technology1999，120，121： | 1 |
| 13 | The development and evaluation of singlecell suspension from wheat and barley as a model system; a first steptowards functional genomics application 显示文摘 | Dong J Steve B Eva V | 2010 | BMC Plant Biology2010，10，： | 1 |
| 14 | Operational modal analysis in the presence of harmonic excitations by the use of transmissibility measurements 显示文摘 | CHRISTOF D GERT D S STEVE V | 2009 | Mechanical Systems and Signal Processing2009，23，： | 1 |
| 15 | Exploiting the attributes of regional ecosystems for landscape design: The role of ecological restoration in ecological engineering显示文摘 | Mark T S Heather C V Steve W | 2007 | Ecological Engineering2007，30，3： | 1 |
| 16 | Aldose reductase inhibition counteracts nitrosative stress and poly ( ADP - ribose) polymerase activation in diabetic rat kidney and high - glucose - exposed human mesangial cells显示文摘 | DREL V R PACHER P STEVES M J | 2006 | Free Radical Bio Med2006，40，8： | 1 |
| 17 | On-line damage detection on a wing panel using transmis- sion of multisine ultrasonic waves 显示文摘 | KRISTOF H PATRICK G STEVE V | 2008 | NDT&E International2008，41，： | 1 |
| 18 | Recent ground subsidence at Crown Road,Tauhara and its probable causes显示文摘 | Bromley C J Steve C Manville V R | | 0，，01： | 1 |
| 19 | A novel monitoring method of wet friction clutches based on the post-lockup torsional vibration signal显示文摘 | Agusmian P O Jean M P Steve V | 2013 | Mechanical Systems and Signal Processing2013，35，： | 1 |
| 20 | Neurophysiologic find- ings in early acute inflammatorydemyelinating polyradiculoneu- ropathy显示文摘 | Steve V Kevin DC Black KR | 2004 | Clinical Neurophysiology2004，115，： | 1 |
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