| 1 | Sitagliptin protects rat kidneys from acute ischemia- reperfusion injury via upregulation of GLP-1 and GLP-1 receptors显示文摘Aim: Sitagliptin, an oral glucose-lowering agent, has been found to produce cardiovascular protection possibly via anti-inflammatory and anti-atherosclerotic activities of glucagon-like peptide-1 receptor (GLP-1). The aim of this study was to investigate whether sitagliptin protected the kidney function from acute ischemia-reperfusion (IR) injury in rats. Methods: Adult male SD rats were categorized into 4 groups: sham control, IR injury, IR+sitagliptin (300 mg/kg) and IR+sitagliptin (600 mg/kg). Acute renal IR injury of both kidneys was induced by clamping the renal pedicles for I h. The drug was orally administered at 1, 24 and 48 h after acute IR. Blood samples and 24-h urine were collected before and at 72 h after acute IR. Then the rats were sacrificed, and the kidneys were harvested for biochemical and immunohistochemical studies. | Meng-wei CHANG Chih-hung CHEN Yi-ching CHEN Yin-chun WU Yen-yi ZHEN Steve LEU Tzu-hsien TSAI Sheung-fat KO Pei-hsun SUNG Chih-chau YANG Hsin-ju CHIANG Hsueh-wen CHANG Yen-ta CHEN Hon-kan YIP | 2015 | Acta Pharmacologica Sinica2015，36，1： | 6 |
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