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| 1 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 2 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 3 | What are the current and potential future roles for endoscopic ultrasound in the treatment of pancreatic cancer?显示文摘Pancreatic adenocarcinoma is the fourth leading cause of cancer-related death in the United States. Due to the aggressive tumor biology and late manifestations of the disease, long-term survival is extremely uncommon and the current 5-year survival rate is 7%. Over the last two decades, endoscopic ultrasound(EUS) has evolved from a diagnostic modality to a minimally invasive therapeutic alternative to radiologic procedures and surgery for pancreatic diseases. EUSguided celiac plexus intervention is a useful adjunct to conventional analgesia for patients with pancreatic cancer. EUS-guided biliary drainage has emerged as a viable option in patients who have failed endoscopic retrograde cholangiopancreatography. Recently, the use of lumen-apposing metal stent to create gastrojejunal anastomosis under EUS and fluoroscopic guidance in patients with malignant gastric outlet obstruction has been reported. On the other hand, anti-tumor therapies delivered by EUS, such as the injection of anti-tumor agents, brachytherapy and ablations are still in the experimental stage without clear survival benefit. In this article, we provide updates on well-established EUS-guided interventions as well as novel techniques relevant to pancreatic cancer. | Stephen Y Oh Shayan Irani Richard A Kozarek | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，7： | 5 |
| 4 | Labeling of influenza viruses with synthetic fluorescent and biotin-labeled lipids显示文摘Direct labeling of virus particles is a powerful tool for the visualization of virus–cell interaction events. However, this technique involves the chemical modification of viral proteins that affects viral biological properties. Here we describe an alternative approach of influenza virus labeling that utilizes Function-Spacer-Lipid(FSL) constructs that can be gently inserted into the virus membrane. We assessed whether labeling with fluorescent(fluo-Ad-DOPE) or biotin-labeled(biot-CMG2-DOPE) probes has any deleterious effect on influenza virus hemagglutinin(HA) receptor specificity, neuraminidase(NA) activity, or replicative ability in vitro. Our data clearly show that neither construct significantly affected influenza virus infectivity or viral affinity to sialyl receptors. Neither construct influenced the NA activities of the influenza viruses tested, except the A/Puerto Rico/8/34(H1N1) strain. Our data indicate that lipid labeling provides a powerful tool to analyze influenza virus infection in vitro. | Natalia A Ilyushina Evgeny S Chernyy Elena Y Korchagina Aleksra S Gambaryan Stephen M Henry Nicolai V Bovin | 2014 | Virologica Sinica2014，29，4： | 2 |
| 5 | Anti-hypertensive drugs in children and adolescents显示文摘Worldwide the prevalence of essential hypertension inchildren and adolescents continues to increase. Tradi-tionally providers have used 'off-label' drugs to treatpediatric hypertension, meaning that rigorous clinicaltrials of these drugs have not been specifically per-formed in pediatric patient populations. Consequentlyproviders have extrapolated dosing, safety and efficacyfrom trials in adults. This practice is sub-optimal as chil-dren demonstrate unique differences in drug metabo-lism and response. Use of unstudied or understudieddrugs increases risk of adverse events and/or can leadto sub-optimal efficacy. Recognizing these concerns,regulatory agencies have created financial incentivesfor industry to conduct pediatric clinical trials. Theseincentives, coupled with the emerging pediatric hyper-tension epidemic, have spurred over 30 clinical trialsof anti-hypertensive drugs over the past 15 years andhave resulted in labeling of 10 new drugs by the UnitedStates Food and Drug Administration for treatment ofhypertension in children and adolescents. Unfortunatelythe financial incentive structures focus on newer drugsand drug classes. Consequently there is now a relativedearth of trial data for older but sometimes commonlyprescribed pediatric antihypertensive drugs. This article reviews recent pediatric antihypertensive drug trials with a focus on trial design and endpoints, drug dosing, safety, efficacy and specific drug indications. We also review the available data and experience for some of the more commonly prescribed, but less well studied 'older' pediatric antihypertensive drugs. | Patricia Y Chu Michael J Campbell Stephen G Miller Kevin D Hill | 2014 | World Journal of Cardiology2014，6，5： | 2 |
| 6 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | 2012 (9859)2012，，9859： | 2 |
| 7 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 8 | Management of facial nerve injury due to temporal trauma显示文摘 | Chang C Y J Stephen P C | 1999 | Am J Otol1999，20，： | 1 |
| 9 | Enhanced removal of organic matter and ammaniacal-nitrogen in a column experiment of tidal flow constructed wetland system 显示文摘 | Sun G Z Zhao Y Q Stephen Allen | 2005 | Journal of Biotechnology2005，115，2： | 1 |
| 10 | Assessment of optimistic self-beliefs: further validation of the Chinese version of the General Self-Efficacy Scale 显示文摘 | Cheung S K Stephen Sun S Y | 1999 | Psychol Rep1999，85，3： | 1 |
| 11 | A stage structured predator-prey model and its dependence on maturation delay and death rate显示文摘 | Stephen A Gourley Kuang Y | 2004 | Journal of Mathematical Biology2004，49，： | 1 |
| 12 | Myeloma- derived Dickkopf-I disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma 显示文摘 | Qiang YW Chen Y Stephens 0 | 2008 | Blood2008，112，： | 1 |
| 13 | Inoprint lithography with 25-nanometer resolation显示文摘 | Stephen Y C Pete R K Preston J R | 1996 | Science1996，272，5： | 1 |
| 14 | Dispersion compensation over 270km at 10 Gbit/s using an offset-core chirped fiber Bragg gratings显示文摘 | Krug P A Stephens T Offe G Y | 1995 | Electrionics Letters1995，31，13： | 1 |
| 15 | Strategic outsourcing for competing OEMs that face cost reduction opportunities 显示文摘 | Stephen G M Xia Y S Yu G | 2006 | IIE Transactions2006，38，11： | 1 |
| 16 | Hematopoietic stem cells convert into liver cells within days without fusion 显示文摘 | JANG Y Y STEPHEN B B ANNA M D | 2004 | Nature Cell Biolo2004，6，6： | 1 |
| 17 | Seismic hazard and risk in Shanghai and estimation of expected building damage 显示文摘 | Stephen W C XU Y B Paul W B | 2008 | Soil Dynamics and Earthquake Engineering2008，28，10： | 1 |
| 18 | Sub-10 nm imprint lithography and applications显示文摘 | Stephen Y Chou Peter R Krauss Zhang Wei | 1997 | Journal of Vacuum Science&Technology B1997，15，6： | 1 |
| 19 | The serine protease and RNA-stimulated nucleoside triphatase and RNA helicase function domains of Dengue virus type 2 NS3 converge within a region of amino acids显示文摘 | Haitao L Stephen C Shihyun Y | 1999 | J Virol1999，73，： | 1 |
| 20 | Paclitaxel resistance and muhicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment显示文摘 | Dong Y Stephens C Walpole C | 2013 | PLoS One2013，8，57： | 1 |
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