3篇
您的检索式：作者名="Stephanie Roessler"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Co-expression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis显示文摘AIM: To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia.METHODS: Formalin-fixed and paraffin-embedded tissues from 190 gastric carcinoma patients were stained with monodonal antibodies recognizing CDX2 and MUC2, respectively. Immunoreactivity was evaluated semiquantitatively and statistical analyses including χ2 tests, uni- and multi-variate survival analyses were performed.RESULTS: CDX2 was mostly expressed in a nuclear or supranuclear pattern, whereas MUC2 showed an almost exclusive supranuclear reactivity. Both antigens were present in >80% of areas exhibiting intestinal metaplasia. An immunoreactivity in >5% of the tumor area was observed in 57% (CDX2) or in 21% (MUC2) of the carcinomas. The presence of both molecules did not correlate with WHO,significantly stronger vlUC2 expression in mucinous tumors). CDX2 correlated with a lower pT and pN stage in the subgroups of intestinal and stage I cancers and was associated with MUC2 positivity. A prognostic impact of CDX2 or MUC2 was not observed. CONCLUSION: CDX2 and MUC2 play an important role in the differentiation of normal, inflamed, and neoplastic gastric tissues. According to our results, loss of CDX2 may represent a marker of tumor progression in early gastric cancer and carcinomas with an intestinal phenotype. | Kristina Roessler Stefan P.M(o|¨)nig Paul M.Schneider Franz-Georg Hanisch Stephanie Landsberg Juergen Thiele Arnulf H.H(o|¨)lscher Hans P.Dienes Stephan E.Baldus | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | Integrated Metabolite and Gene Expression Profiles Identify Lipid Biomarkers Associated With Progression of Hepatocellular Carcinoma and Patient Outcomes显示文摘 | Anuradha Budhu Stephanie Roessler Xuelian Zhao Zhipeng Yu Marshonna Forgues Junfang Ji Edward Karoly Lun–Xiu Qin Qing–Hai Ye Hu–Liang Jia Jia Fan Hui–Chuan Sun Zhao–You Tang Xin Wei Wang | 2013 | Gastroenterology2013，，5： | 1 |
| 3 | GOLM1通过调控EGFR/RTK受体细胞表面再循环途径驱动肝细胞癌转移显示文摘肿瘤转移是癌症,特别是肝癌患者死亡的主要原因。目前,关于癌症转移的机制仍然知之甚少。在肿瘤转移的过程中,表皮生长因子类受体(EGFR)异常活化是促进癌症进展、转移的关键因素。 | Qing-Hai Ye Wen-Wei Zhu Ju-Bo Zhang Yi Qin Ming Lu Guo-Ling Lin Lei Guo Bo Zhang Zhen-Hai Lin Stephanie Roessler Marshonna Forgues Hu-Liang Jia Lu Lu Xiao-Fei Zhang Bao-Feng Lian Lu Xie Qiong-Zhu Dong Zhao-You Tang Xin Wei Wang 钦伦秀 | 2017 | 科学新闻2017，19，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员