6篇
您的检索式：作者名="Stephanie Muller"
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| 1 | Rare presentation of primary (AL) amyloidosis as gastrointestinal hemorrhage without systemic involvement显示文摘We are reporting a rare case of a patient with primary(AL) amyloidosis presenting with an acute non-varicealupper gastrointestinal hemorrhage in the absence ofother systemic involvement. The case report involves a58-year-old woman with significant cardiac history andhereditary blood disorder who came in complaining ofabdominal pain and coffee-ground emesis for two days.Computed tomography(CT) scan of the abdomen andpelvis with contrast revealed segmental wall thickeningof the proximal jejunum with hyperdense, heterog-enous luminal content. Similar findings were evident inthe left lower small bowel region, suspicious for smallbowel hematoma and the possibility of intraluminalclots. Esophagogastroduodenoscopy performed postresuscitation showed punctate, erythematous lesionsthroughout the stomach as well as regions of smallbowel mucosa that appeared scalloped, ulcerated, andhemorrhaged on contact. Despite initial treatment for immunostain-positive focal cytomegalovirus gastritis, follow-up esophagogastroduodenoscopy after two months continued to demonstrate friable and irregular duodenal mucosa hinting at a different underlying etiol-ogy. Pathology reports from analyses of biopsy samples highlighted infiltration and expansion of the lamina pro-pria and submucosa. Subsequent staining with congo red/crystal violet and appropriate subtyping established the diagnosis of AL(kappa)-type amyloidosis. The sig-nificance of this case lies in the fact that our patient did not have the typically seen diagnostic systemic involvements-namely of heart and kidneys-usually seen in primary(AL) amyloidosis patients. It was the persis-tent endoscopic findings and biopsy results which gave clues to the physicians regarding the possibility of an abnormal protein-deposition entity. | Mohammad F Ali Anik Patel Stephanie Muller David Friedel | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 2 | Identification of insulin signaling elements in human b-cells-autocrin regulation of insulin gene expression显示文摘 | Muller D Guo CH Stephanie Amiel | 2006 | Diabetes2006，55，： | 1 |
| 3 | Identification of insulin signaling elements in humanβCells autocrine regulation of insulin gene expression 显示文摘 | MULLER DANY GUO CAI HUANG STEPHANIE AMIEL | 2006 | Diabetes2006，，55： | 1 |
| 4 | Identification of insulin signaling elements in human b-cells-autocrine regulation of insulin gene expression显示文摘 | Muller D Guo CH Stephanie Amiel | 2006 | Diabetes2006，55，： | 1 |
| 5 | Medical effectiveness and safety of conventional compared to laparoscopic incisional Hernia repair: A systematic review 显示文摘 | Falk Muller Riemenschneider Stephanie Roll Meik Friedrlch | 2007 | Surg Endosc2007，21，12： | 1 |
| 6 | Single-cell protein profiling in microchambers with barcoded beads显示文摘Single-cell profiling provides insights into cellular behaviour that macroscale cell cultures and bulk measurements cannot reveal.In the context of personalized cancer treatment,the profiling of individual tumour cells may lead to higher success rates for therapies by rapidly selecting the most efficacious drugs.Currently,genomic analysis at the single-cell level is available through highly sensitive sequencing approaches.However,the identification and quantification of intracellular or secreted proteins or metabolites remains challenging.Here,we introduce a microfluidic method that facilitates capture,automated data acquisition and the multiplexed quantification of proteins from individual cells.The microfluidic platform comprises 1026 chambers with a volume of 152 pL each,in which single cells and barcoded beads are co-immobilized.We demonstrated multiplexed single-cell protein quantification with three different mammalian cell lines,including two model breast cancer cell lines.We established on-chip immunoassays for glyceraldehyde-3-phosphate dehydrogenase(GAPDH),galectin-3(Gal-3)and galectin-3 binding protein(Gal-3bp)with detection limits as low as 7.0×10^(4),2.3×10^(5)and 1.8×10^(3)molecules per cell,respectively.The three investigated cell types had high cytosolic levels of GAPDH and could be clearly differentiated by their expression levels of Gal-3 and Gal-3bp,which are important factors that contribute to cancer metastasis.Because it employed commercially available barcoded beads for this study,our platform could be easily used for the single-cell protein profiling of several hundred different targets.Moreover,this versatile method is applicable to the analysis of bacteria,yeast and mammalian cells and nanometre-sized lipid vesicles. | Lucas Armbrecht Rafael Sebastian Muller Jonas Nikoloff Petra Stephanie Dittrich | 2019 | Microsystems & Nanoengineering2019，5，1： | 0 |
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