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| 1 | Iterative Cytoreductive Surgery Associated With Hyperthermic Intraperitoneal Chemotherapy for Treatment of Peritoneal Carcinomatosis of Colorectal Origin With or Without Liver Metastases显示文摘 | Reza Kianmanesh Stefano Scaringi Jean-Marc Sabate Benjamin Castel Nathalie Pons-Kerjean Benoit Coffin Jean-Marie Hay Yves Flamant Simon Msika | 2007 | Annals of Surgery2007，，4： | 1 |
| 2 | Iterative Cytoreductive Surgery Associated With Hyperthermic Intraperitoneal Chemotherapy for Treatment of Peritoneal Carcinomatosis of Colorectal Origin With or Without Liver Metastases显示文摘 | Reza Kianmanesh Stefano Scaringi Jean-Marc Sabate Benjamin Castel Nathalie Pons-Kerjean Benoit Coffin Jean-Marie Hay Yves Flamant Simon Msika | 2007 | Annals of Surgery2007，，： | 1 |
| 3 | Gastro-Esophageal Reflux and Esophageal Motility Disorders in Morbidly Obese Patients before and after Bariatric Surgery显示文摘 | Mohamed Merrouche Jean-Marc Sabaté Pauline Jouet Florence Harnois Stefano Scaringi Benoit Coffin Simon Msika | 2007 | Obesity Surgery2007，，7： | 1 |
| 4 | Gastro-Esophageal Reflux and Esophageal Motility Disorders in Morbidly Obese Patients before and after Bariatric Surgery显示文摘 | Mohamed Merrouche Jean-Marc Sabaté Pauline Jouet Florence Harnois Stefano Scaringi Benoit Coffin Simon Msika | 2007 | Obesity Surgery2007，，7： | 1 |
| 5 | Iterative Cytoreductive Surgery Associated With Hyperthermic Intraperitoneal Chemotherapy for Treatment of Peritoneal Carcinomatosis of Colorectal Origin With or Without Liver Metastases显示文摘 | Reza Kianmanesh Stefano Scaringi Jean-Marc Sabate Benjamin Castel Nathalie Pons-Kerjean Benoit Coffin Jean-Marie Hay Yves Flamant Simon Msika | 2007 | Annals of Surgery2007，，4： | 1 |
| 6 | Multiplex gene expression profile in inflamed mucosa of patients with Crohn’s disease ileal localization: A pilot study显示文摘BACKGROUND Crohn’s disease (CD) is a complex disorder resulting from the interaction of genetic,environmental,and microbial factors.The pathogenic process may potentially affect any segment of the gastrointestinal tract,but a selective location in the terminal ileum was reported in 50% of patients.AIM To characterize clinical sub-phenotypes (colonic and/or ileal) within the same disease,in order to identify new therapeutic targets.METHODS 14 consecutive patients undergoing surgery for ileal CD were recruited for this study.Peripheral blood samples from each patient were collected and the main polymorphisms of the gene Card15/Nod2 (R702W,G908R,and 1007fs) were analyzed in each sample.In addition,tissue samples were taken from both the tract affected by CD and from the apparently healthy and disease-free margins (internal controls).We used a multiplex gene assay in specimens obtained from patients with ileal localization of CD to evaluate the simultaneous expression of 24 genes involved in the pathogenesis of the disease.We also processed surgery gut samples with routine light microscopy (LM) and transmission electron microscopy (TEM) techniques to evaluate their structural and ultrastructural features.RESULTS We found a significant increase of Th17 (IL17A and IL17F,IL 23R and CCR6) and Th1 (IFN-γ) gene expression in inflamed mucosa compared to non-inflamed sites of 14 CD patients.DEFB4 and HAMP,two genes coding for antimicrobial peptides,were also strongly activated in inflamed ileal mucosa,suggesting the overwhelming stimulation of epithelial cells by commensal microbiota.IFN-γ and CCR6 were more expressed in inflamed mucosa of CD patients with ileal localization compared with patients with colonic localization suggesting a more aggressive inflammation process in this site.Morphological analysis of the epithelial lining of Lieberkün crypts disclosed enhanced release activity from goblet mucocytes,whereas the lamina propria contained numerous cells pertaining to various lines.CONCLUSION We observed that the expression of ileal genes related to Th1 and Th17 activity is strongly activated as well as the expression of genes involved in microbiota regulation. | Francesco Giudici Letizia Lombardelli Edda Russo Tiziana Cavalli Daniela Zambonin Federica Logiodice Ornela Kullolli Lamberto Giusti Tatiana Bargellini Marilena Fazi Livia Biancone Stefano Scaringi Ann Maria Clemente Eloisa Perissi Giovanni Delfino Maria G Torcia Ferdinando Ficari Francesco Tonelli Marie-Pierre Piccinni Cecilia Malentacchi | 2019 | World Journal of Clinical Cases2019，7，17： | 1 |
| 7 | Safer intestinal invagination for a solid pancre-atico-jejunal anastomosis in presence of a soft texture pancreatic remnant and non-dilated duct显示文摘Pancreatico-jejunal anastomosis after pancreatoduodenectomy still represents the Achilles' heel of the procedure:the failure of this anastomosis is relatively common and it is the main cause of post-operative morbidity and mortality.Studies have described different reconstruction strategies for the control of the development of post-operative pancreatic fistula,but the strategy to obtain a safer pancreatico-jejunal anastomosis is still far from satisfaction.We report a novel variation of the invagination technique based on preliminary clinical experience in 8 patients who underwent pancreaticojejunal anastomosis after pancreatoduodenectomy in our hepatobiliopancreatic center from 2008 to 2014.The variation could obtain a safer intestinal invagination for a solid pancreatico-jejunal anastomosis even in the presence of soft pancreatic remnant. | francesco giudici benedetta pesi daniela zambonin stefano scaringi paolo bechi giacomo batignani | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，3： | 0 |
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