|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2型糖尿病患者个体化血糖控制目标和药物治疗显示文摘'有效管理糖尿病全球合作组织'(下称'糖尿病全球合作组织')成立的宗旨是为临床提供实用指南以改善糖尿病患者的预后,制定并修改相关策略以改善T2DM患者血糖控制情况。糖尿病全球合作组织提倡对糖尿病患者实行个体化治疗方案,明确需要特殊考虑T2DM患者亚组人群。这篇文章基于此前发表的文献,扩大了实用指南的范围,包括有并发症的新诊断T2DM患者和妊娠期糖尿病(GDM)患者。良好血糖控制是T2DM管理的基石,在预防或延缓糖尿病并发症的发生、发展过程中发挥重要作用。个体化治疗目标和安全及时的血糖达标治疗方案至关重要。另外,还需制定更全面的护理计划以降低心血管风险和改善患者预后。 | 张晓梅 纪立农 Bailey CJ Aschner P Stefano Del Prato LaSalle J JI Li-nong Matthaei S | 2014 | 中国糖尿病杂志2014，22，10： | 16 |
| 2 | Pancreatic duct guidewire placement for biliary cannulation in a single-session therapeutic ERCP显示文摘AIM: To investigate the technical success and clinical complication rate of a cannulated pancreatic duct with guidewire for biliary access. METHODS: During a five-year study period, a total of 2843 patients were included in this retrospective analysis. Initial biliary cannulation method consisted of single-guidewire technique (SGT) for up to 5 attempts, followed by double-guidewire technique (DGT) when repeated unintentional pancreatic duct cannulation had taken place. Pre-cut papillotomy technique was reserved for when DGT had failed or no pancreatic duct cannulation had been previously achieved. Main outcome measurements were defined as biliary cannu-lation success and post-endoscopic retrograde cholangiopancreatography (ERCP) complication rate. RESULTS: SGT (92.3% success rate) was characterized by statistically significant enhanced patient outcome compared to either the DGT (43.8%, P < 0.001), pre-cut failed DGT (73%, P < 0.001) or pre-cut as first step method (80.6%, P = 0.002). Pre-cut as first step method offered a statistically significantly more favorable outcome compared to the DGT (P < 0.001). The incidence of post-ERCP pancreatitis did not differ in a statistically significant manner between either method (SGT: 5.3%, DGT: 6.1%, Pre-cut failed DGT: 7.9%, Pre-cut as first step: 7.5%) or with patients' gender. CONCLUSION: Although DGT success rate proved not to be superior to SGT or pre-cut papillotomy, it is considered highly satisfactory in terms of safety in order to avoid the risk of a pre-cut when biliary therapy is necessary in difficult-to-cannulate cases. | Dimitrios Xinopoulos Stefanos P Bassioukas Dimitrios Kypreos Dimitrios Korkolis Andreas Scorilas Konstantinos Mavridis Dimitrios Dimitroulopoulos Emmanouil Paraskevas | 2011 | World Journal of Gastroenterology2011，17，15： | 8 |
| 3 | Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes显示文摘Fas/CD95 表面受体调停各种各样的房间的快速的死亡打字,包括有为触发 autoimmunity 的潜力的 autoreactive T 房间。这里,我们表明那的船边交货的现在的新奇方面定义一种“社会”的尺寸到导致受体的 apoptosis。船边交货刺激很快导致在附近的 T 房间之间的广泛的膜 nanotube 形成。这极其依赖于 Rho GTPases 然而并非在 caspase 激活上。包括活跃 caspases 的膜和 cytosolic 元素的双向转移能被观察经由这些 nanotubes 发生。Nanotube 形成和死亡信号的细胞间的交换在从有在船边交货受体的自体免疫的 lymphoproliferative 症候群 harbouring 变化的病人的 T 淋巴细胞是有缺点的。我们断定调停 nanotube 的交换组成扩充在附近的 T 房间之间发信号的死亡的繁殖的细胞间的通讯的一种新奇形式。 | Peter D Arkwright Francesca Luchetti Julien Tour Charlotte Roberts Rahna Ayub Ana P Morales Jose J Rodriguez Andrew Gilmore Barbara Canonico Stefano Papa Mauro Degli Esposti | 2010 | Cell Research2010，20，1： | 4 |
| 4 | Modern diagnostic approaches to cholangiocarcinoma显示文摘BACKGROUND:Cholangiocarcinoma is a very aggressive tumor with poor survival.Therefore,early diagnosis and surgical resection are of paramount importance.Its diagnosis is difficult because access to the tumor is not easy.Biopsy is possible only for intrahepatic cholangiocarcinoma,which accounts for 10% of cases.Routine brush cytology from endoscopic retrograde cholangiopancreatography(ERCP) has a high specificity of 100% but unfortunately a low sensitivity of 30%.In this review we briefly describe new diagnostic techniques applicable to ERCP brush cytology specimens and targeting the genetic background of the disease,in particular fluorescence in situ hybridization(FISH) and digital image analysis(DIA).DATE SOURCES:The PubMed database up to 2011 was used for the retrieval of relevant articles.The search terms FISH,fluorescence in situ hybridization,DIA,digital image analysis and cholangiocarcinoma were used.Both original and review articles were used.RESULTS:FISH identifies cells with chromosomal abnormalities,mainly numerical aberrations,using a mixture of fluorescencelabeled probes.FISH offers a higher sensitivity than routine cytology,retaining a high level of specificity.The DIA criterion for malignancy is demonstration of aneuploidy.This technique increases the sensitivity to 40%,but the specificity remains low.Preliminary data from application to other tumors suggest that combination of FISH and DIA may be of further benefit.CONCLUSIONS:The new techniques offer a significantly enhanced diagnostic efficacy in the evaluation of ERCP brush specimens.Apart from contributing to a more timely diagnosis,their wider application to cholangiocarcinoma may also facilitate the genetic study of the disease and add to our understanding of oncogenesis at the molecular level,with the prospect of identifying targets for novel therapeutic interventions. | Larisa E Vasilieva Stefanos I Papadhimitriou Spyros P Dourakis | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 2 |
| 5 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 6 | Seismic performance of non-structural components and contents in buildings: an overview of NZ research显示文摘This paper summarizes the research on non-structural elements and building contents being conducted at University of Canterbury in New Zealand.Since the 2010-2011 series of Canterbury earthquakes,in which damage to non-structural components and contents contributed heavily to downtime and overall financial loss,attention to seismic performance and design of non-structural components and contents in buildings has increased exponentially in NZ.This has resulted in an increased allocation of resources to research leading to development of more resilient non-structural systems in buildings that would incur substantially less damage and cause little downtime during earthquakes.In the last few years,NZ researchers have made important developments in understanding and improving the seismic performance of secondary building elements such as partitions,facades,ceilings and contents. | Rajesh P Dhakal Atefeh Pourali Ali Sahin Tasligedik Trevor Yeow Andrew Baird Gregory Mac Rae Stefano Pampanin Alessandro Palermo | 2016 | Earthquake Engineering and Engineering Vibration2016，15，1： | 2 |
| 7 | Bone metabolism in type 2 diabetes mellitus显示文摘 | Isaia GC Ardissone P Di Stefano M | 1999 | Acta Diabeto1999，36，12： | 1 |
| 8 | Emotion recognition through facial expression analysis based on a neurofuzzy network显示文摘 | Spiros V Ioannou Amaryllis T RaouzAiou Vasilis A Tzouvaras Theofilos P MAilis Kostas C Karpouzis Stefanos D Kollias | 2005 | Neural Networks2005，，： | 1 |
| 9 | Hyperhomocysteinemia and other inherited prothrombotic conditions in young adults with a history of ischemi stroke显示文摘 | Madonna P De Stefano V | 2002 | Stroke2002，33，1： | 1 |
| 10 | Cystatin C and estimates of renal function:searching for a better measure of kidney function in diabetic patients显示文摘 | Laura P Stefano T Lucchesi D | 2007 | Clin Chem2007，53，3： | 1 |
| 11 | Noise reduction in spine videofluoroscopic images using the undecimated wavelet transform显示文摘 | De Stefano A Allen R White P R | 2004 | Computerized Medical Imaging and Graphics2004，28，： | 1 |
| 12 | Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients显示文摘 | Stefano V Chiusolo P Paciaroni K | 1998 | Blood1998，91，： | 1 |
| 13 | Electroluminescence of silicon nanocrystals in MOS structures显示文摘 | Franzò G Irrera A Moreira E C Miritello M Iacona F Sanfilippo D Di Stefano G Fallica P G Priolo F | | 0，，： | 1 |
| 14 | Chemokines and chemokine receptors blockers as new drugs for the treatment of chronic obstructive pulmonary disease显示文摘 | Caramori G Di Stefano A Casolari P | 2013 | Curr Med Chem2013，20，35： | 1 |
| 15 | Bioactivity of TiN-coated titanium implants显示文摘 | Stefano P Lucio C C Erik V | 2004 | Acta Mater2004，52，5： | 1 |
| 16 | Payments for Environmental Services in Costa Rica显示文摘 | Stefano P | 2008 | Ecological Economics2008，，65： | 1 |
| 17 | Study of A1 Alloy Corrosion in Neutral NaC1 by the Pitting Scan Technique显示文摘 | MONICA Trueba STEFANO P Trasatti | 2010 | Materials Chemistry and Physics2010，121，3： | 1 |
| 18 | Hyperhomocysteinemia and other inherited prothrombotic conditions in young adults with history of ischemic stroke 显示文摘 | Madonna P de Stefano V Coppola A | 2002 | Stroke2002，33，1： | 1 |
| 19 | p130Cas: a versatile scaffold in signaling networks显示文摘 | Defdippi P Di Stefano P Gabodi S | 2006 | Trends Cell Biol2006，16，5： | 1 |
| 20 | Analysis of potential predictors of depression among coronary heart disease risk factors including heart rate varia- bility, markers of inflammation, and endothelial function 显示文摘 | Carmine P Lamberto M Stefano M | 2008 | Eur Heart J2008，29，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员