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| 1 | Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence显示文摘AIM: To demonstrate that administering heparanase inhibitor PI-88 at 160 mg/d is safe and promising in reducing hepatocellular carcinoma(HCC) recurrence for up to 3 year following curative resection. METHODS: A total of 143 patients(83.1% of the 172 participants in the phase Ⅱ study) participated in the follow-up study. Of these patients, 50 had received no treatment, 48 had received 160 mg/d PI-88, and 45 had received 250 mg/d PI-88 during the phase Ⅱ trial. Safety parameters and the following efficacy endpoints were investigated:(1) time to recurrence;(2) diseasefree survival; and(3) overall survival. RESULTS: PI-88 at 160 mg/d delayed the onset and frequency of HCC recurrence, and provided a clinically significant survival advantage for up to 3 years after treatment compared with those of the control group:(1) the recurrence-free rate increased from 50% to 63%, and(2) time to recurrence at the 36 th percentile was postponed by 78%. The efficacy of administering PI-88 at 250 mg/d was confounded by a high dropout rate(11 out of 54 patients). Additionally, subgroup analyses of patients with(1) multiple tumors or a single tumor ≥ 2 cm; and(2) hepatitis B or C revealed that administering PI-88 at 160 mg/d conferred the most significant survival advantage(56.8% improvement in disease-free survival, P = 0.045) for patients with both risk factors for recurrence. CONCLUSION: Administering PI-88 at 160 mg/d is a safe and well-tolerated dosage that may confer significant clinical benefits for patients with HCC. | Chun-Jen Liu Juliana Chang Po-Huang Lee Deng-Yn Lin Cheng-Chung Wu Long-Bin Jeng Yih-Jyh Lin King-Tong Mok Wei-Chen Lee Hong-Zen Yeh Ming-Chih Ho Sheng-Shun Yang Mei-Due Yang Ming-Chin Yu Rey-Heng Hu Cheng-Yuan Peng Kuan-Lang Lai Stanley Shi-Chung Chang Pei-Jer Chen | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 2 | Liquid crystal display and organic light-emitting diode display: present status and future perspectives显示文摘Recently,‘Liquid crystal display(LCD)vs.organic light-emitting diode(OLED)display:who wins?’has become a topic of heated debate.In this review,we perform a systematic and comparative study of these two flat panel display technologies.First,we review recent advances in LCDs and OLEDs,including material development,device configuration and system integration.Next we analyze and compare their performances by six key display metrics:response time,contrast ratio,color gamut,lifetime,power efficiency,and panel flexibility.In this section,we focus on two key parameters:motion picture response time(MPRT)and ambient contrast ratio(ACR),which dramatically affect image quality in practical application scenarios.MPRT determines the image blur of a moving picture,and ACR governs the perceived image contrast under ambient lighting conditions.It is intriguing that LCD can achieve comparable or even slightly better MPRT and ACR than OLED,although its response time and contrast ratio are generally perceived to be much inferior to those of OLED.Finally,three future trends are highlighted,including high dynamic range,virtual reality/augmented reality and smart displays with versatile functions. | Hai-Wei Chen Jiun-Haw Lee Bo-Yen Lin Stanley Chen Shin-Tson Wu | 2017 | Light(Science & Applications)2017，6，1： | 3 |
| 3 | Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage显示文摘 | Chun-Jen Liu Po-Huang Lee Deng-Yn Lin Cheng-Chung Wu Long-Bin Jeng Pin-Wen Lin King-Tong Mok Wei-Chen Lee Hong-Zen Yeh Ming-Chih Ho Sheng-Shun Yang Ching-Chih Lee Ming-Chin Yu Rey-Heng Hu Cheng-Yuan Peng Kuan-Lang Lai Stanley Shi-Chung Chang Pei-Jer Chen | 2009 | Journal of Hepatology2009，，5： | 2 |
| 4 | Neural Stem Cells: Implications for the Conventional Radiotherapy of Central Nervous System Malignancies显示文摘 | Igor J. Barani Stanley H. Benedict Peck-Sun Lin | 2007 | International Journal of Radiation Oncology Biology Physics2007，，2： | 1 |
| 5 | Preparation and characterisation of rose Bengal-loaded surface-modified albumin nanoparticles显示文摘 | Wu Lin Martin C G Stanley S D | 2001 | J Controlled Release2001，71，1： | 1 |
| 6 | Antitumor Effect of VNP20009,an AttenuatedSalmonella,in Murine Tumor Models显示文摘 | Xiang Luo Zujin Li Stanley Lin | 2001 | Oncology Research2001，12，： | 1 |
| 7 | A Prospective, Randomized, Controlled Trial of Single-Incision Laparoscopic (SILS) versus Conventional 3-port Laparoscopic Appendectomy for the Treatment of Acute Appendicitis显示文摘 | Jonathan T. Carter Jennifer A. Kaplan Jason N. Nguyen Matthew Y.C. Lin Stanley J. Rogers Hobart W. Harris | 2013 | Journal of the American College of Surgeons2013，，： | 1 |
| 8 | Covariance spectroscopy in high-resolution multi-dimensional solid-state NMR 显示文摘 | Eugene C Lin Stanley J Opella | 2013 | Journal of Magnetic Resonance2013，239，： | 1 |
| 9 | Identification, proliferation, and differentiation of adult Leydig stem ceils 显示文摘 | Stanley E Lin CY Jin S | 2012 | Endocrinology2012，153，10： | 1 |
| 10 | INFLUENCE OF THE Rh (D) BLOOD GROUP SYSTEM ON GRAFT SURVIVAL IN RENAL TRANSPLANTATION显示文摘 | Christopher F. Bryan Stanley I. Mitchell Hung Mo Lin Paul W. Nelson Charles F. Shield Alan M. Luger George E. Pierce Gilbert Ross Bradley A. Warady Mark I. Aeder Thomas S. Helling Michael D. Landreneau Kevin M. Harrell | 1998 | Transplantation1998，，4： | 1 |
| 11 | Survival Factor-Mediated BAD Phosphorylation Raises the Mitochondrial Threshold for Apoptosis显示文摘 | Sandeep Robert Datta Ann M. Ranger Michael Z. Lin James Fitzhugh Sturgill Yong-Chao Ma Chris W. Cowan Pieter Dikkes Stanley J. Korsmeyer Michael E. Greenberg | 2002 | Developmental Cell2002，，5： | 1 |
| 12 | Telomerase‐specific oncolytic adenoviral therapy for orthotopic hepatocellular carcinoma in HBx transgenic mice显示文摘 | Wei‐Hsiang Lin Shiou‐Hwei Yeh Wan‐Jen Yang Kun‐Huei Yeh Toshiyoshi Fujiwara Aisuke Nii Stanley Shi‐Chung Chang Pei‐Jer Chen | 2012 | Int J Cancer2012，，6： | 1 |
| 13 | 麦芽糖结合蛋白-微管驱动蛋白11删除型融合基因表达载体的构建及其蛋白表达显示文摘目的:构建删除型微管驱动蛋白(KIF)11与麦芽糖结合蛋白(MBP)的融合蛋白的原核表达载体,并纯化得到高纯度的MBP-删除型KIF11融合蛋白。方法:PCR法从全长的KIF11基因组中扩增KIF11的相关删除型基因并连接到原核表达载体pMal中,此载体包含一个表达MBP的基因,删除型KIF11片段插入后与其融合,筛选和测序鉴定阳性克隆。将重组质粒转化到Rosseta大肠杆菌中,经异丙基硫代-β-D-半乳糖苷诱导表达和亲和层析分离纯化表达产物,对纯化的蛋白进行十二烷基磺酸钠-聚丙烯酰胺凝胶电泳法(SDS-PAGE)和蛋白质免疫印迹杂交(Western blot)鉴定。结果:成功扩增删除型KIF11基因,构建MBP-KIF11-head,-stalk和-tail重组质粒并在Rosseta中诱导表达出MBP-KIF11-head,-stalk,-tail融合蛋白。经SDS-PAGE和Western blot法验证了高纯度纯化的融合蛋白。结论:建立了高效稳定的MBP-KIF11表达体系,为进一步研究KIF11与mRNA调控蛋白锌指结合蛋白1相互作用的区域打下基础。 | 宋婷婷 黄振强 郑意 宫瑾 Stanley Lin 顾巍 | 2013 | 汕头大学医学院学报2013，26，2： | 0 |
| 14 | Spatiotemporal Input Control:Leveraging Temporal Variation in Network Dynamics显示文摘The number of available control sources is a limiting factor to many network control tasks.A lack of input sources can result in compromised controllability and/or sub-optimal network performance,as noted in engineering applications such as the smart grids.The mechanism can be explained by a linear timeinvariant model,where structural controllability sets a lower bound on the number of required sources.Inspired by the ubiquity of time-varying topologies in the real world,we propose the strategy of spatiotemporal input control to overcome the source-related limit by exploiting temporal variation of the network topology.We theoretically prove that under this regime,the required number of sources can always be reduced to 2.It is further shown that the cost of control depends on two hyperparameters,the numbers of sources and intervals,in a trade-off fashion.As a demonstration,we achieve controllability over a complex network resembling the nervous system of Caenorhabditis elegans using as few as 6%of the sources predicted by a static control model.This example underlines the potential of utilizing topological variation in complex network control problems. | Yihan Lin Jiawei Sun Guoqi Li Gaoxi Xiao Changyun Wen Lei Deng H.Eugene Stanley | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，4： | 0 |
| 15 | The Impact of Satellite Radiance Data Assimilation within a Frequently Updated Regional Forecast System Using a GSI-based Ensemble Kalman Filter显示文摘A regional ensemble Kalman filter (EnKF) data assimilation (DA) and forecast system was recently established based on the Gridpoint Statistical Interpolation (GSI) analysis system. The EnKF DA system was tested with continuous threehourly updated cycles followed by 18-h deterministic forecasts from every three-hourly ensemble mean analysis. Initial tests showed negative to neutral impacts of assimilating satellite radiance data due to the improper bias correction procedure. In this study, two bias correction schemes within the established EnKF DA system are investigated and the impact of assimilating additional polar-orbiting satellite radiance is also investigated. Two group experiments are conducted. The purpose of the first group is to evaluate the bias correction procedure. Two online bias correction methods based on GSI 3DVar and EnKF algorithms are used to assimilate AMSU-A radiance data. Results show that both variational and EnKF-based bias correction procedures effectively reduce the observation and background radiance differences, achieving positive impacts on forecasts. With proper bias correction, we assimilate full radiance observations including AMSU-A, AMSU-B, AIRS, HIRS3/4, and MHS in the second group. The relative percentage improvements (RPIs) for all forecast variables compared to those without radiance data assimilation are mostly positive, with the RPI of upper-air relative humidity being the largest. Additionally, precipitation forecasts on a downscaled 13-km grid from 40-km EnKF analyses are also improved by radiance assimilation for almost all forecast hours. | Kefeng ZHU Ming XUE Yujie PAN Ming HU Stanley G. BENJAMIN Stephen S. WEYGANDT Haidao LIN | 2019 | Advances in Atmospheric Sciences2019，36，12： | 0 |
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