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| 1 | Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases显示文摘BACKGROUND: The well-known functions of bile acids(BAs) are the emulsification and absorption of lipophilic xenobiotics. However, the emerging evidences in the past decade showed that BAs act as signaling molecules that not only autoregulate their own metabolism and enterohepatic recirculation, but also as important regulators of integrative metabolism by activating nuclear and membrane-bound G protein-coupled receptors. The present review was to get insight into the role of maintenance of BA homeostasis and BA signaling pathways in development and management of hepatobiliary and intestinal diseases.DATA SOURCES: Detailed and comprehensive search of PubM ed and Scopus databases was carried out for original and review articles.RESULTS: Disturbances in BA homeostasis contribute to the development of several hepatobiliary and intestinal disorders, such as non-alcoholic fatty liver disease, liver cirrhosis, cholesterol gallstone disease, intestinal diseases and both hepatocellular and colorectal carcinoma.CONCLUSION: Further efforts made in order to advance the understanding of sophisticated BA signaling network may be promising in developing novel therapeutic strategies related not only to hepatobiliary and gastrointestinal but also systemic diseases. | Bojan Stanimirov Karmen Stankov Momir Mikov | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，1： | 11 |
| 2 | 缺氧中和缺氧后亚低温时炎症基因表达谱的变化显示文摘目的了解缺氧中和缺氧后亚低温时炎症相关基因的变化。方法将体外培养的人脑血管内皮细胞(HCEC)分为对照组和实验组。对照组细胞常规培养,实验组细胞去掉细胞培养液,更换为无血清、低糖M199,置于缺氧箱房中,再分为2组:Ⅰ组为常温缺氧后低温恢复;Ⅱ组为低温缺氧后常温恢复。取细胞并分离总RNA后,用DNA微列阵技术观察缺氧以及缺氧中和缺氧后亚低温时HCEC炎症相关基因表达谱的变化。结果1)白介素-1受体1型(IL-1R1)、类1型白介素-1受体(IL-1RL1)、白介素-1β(IL-1β)、白介素-11(IL-11)、γ-干扰素调节因子2(IRF2)和集落刺激因子1(CSF1)分别在某些时间点上调;白介素-1受体拮抗剂(IL-1RN)、白介素-6(IL-6)、γ-干扰素受体2(IFNGR2)、集落刺激因子3受体(CSF3R)、淋巴细胞黏附因子1(SELL)、细胞间黏附因子3(ICAM3)、血小板/内皮细胞黏附因子(PECAM1)和内皮细胞黏附因子1(SELE)则在不同的时间点下调;γ-干扰素诱导蛋白30(IFI30)在某一些时间点上调,但在低温缺氧后常温恢复时下调;肿瘤坏死因子家庭成员7(TNFRSF7)则仅在低温时下调。2)缺氧4 h、32℃低温使下调基因增多。结论缺氧可以使IL-1βI、L-1RL1I、L-1R1等部分损伤性炎症基因表达上调,IL-11的上调可能为保护性反应;TNF基因表达的上调可能起双重作用。 | 崔红 张万东 Jamie Hutchison Danica Stanimirovic | 2006 | 首都医科大学学报2006，27，1： | 4 |
| 3 | Design and analysis of recurrent neural network models with non-linear activation functions for solving time-varying quadratic programming problems显示文摘A special recurrent neural network(RNN),that is the zeroing neural network(ZNN),is adopted to find solutions to time-varying quadratic programming(TVQP)problems with equality and inequality constraints.Howevet,there are some weaknesses in activation functions of traditional ZNN models,including convex restriction and redundant formulation.With the aid of different activation functions,modified ZNN models are obtained to overcome the drawbacks for solving TVQP problems.Theoretical and experimental research indicate that the proposed models are better and more effective at solving such TVQP problems. | Xiaoyan Zhang Liangming Chen Shuai Li Predrag Stanimirovic Jiliang Zhang Long Jin | 2021 | CAAI Transactions on Intelligence Technology2021，6，4： | 2 |
| 4 | 显示文摘 | Stanimirovic DB Wong J Shapiro A | 1997 | Aeta Neurochir Suppl (wien)1997，70，： | 1 |
| 5 | Pleiotropic functions of bile acids mediated by the farnesoid X receptor 显示文摘 | Stanimirov B Stankov K Mikov M | 2012 | Acta Gastroenterol Belg2012，75，4： | 1 |
| 6 | TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk 显示文摘 | Stanimirovic D Zeljic K Jankovic L | 2013 | Eur J Oral Sci2013，121，5： | 1 |
| 7 | On the generalized Drazin inverse and generalized resolvent 显示文摘 | DJORDJEVIC D S STANIMIROVIC P S | 2001 | Czechoslovak Math J2001，51，： | 1 |
| 8 | Determinantal representation of weighted Moore-Penrose inverse显示文摘 | Stanimirovic P Stankovic M | 1994 | Matematicki Vesnik1994，46，12： | 1 |
| 9 | Edothelin21 receptor binding and cellular signal transduction in cultured human brain endothelial cells显示文摘 | Stanimirovic DB Yamamoto T Uematsu S | 1994 | J Neurochem1994，62，： | 1 |
| 10 | Two genetic algorithms for solving the uncapacitated single allocation p- hub median problem显示文摘 | Kratica J Stanimirovic Z Tosic D | 2007 | European Journal of Operational research2007，，182： | 1 |
| 11 | Vasoconstrictive pep-tides induce endothelin-1 and prostanoids in human cerebromicro-vascular endothelium显示文摘 | Spatz M Stanimirovic D Bacic F | 1994 | Am J Physiol1994，266，3： | 1 |
| 12 | Inflammatory mediators of cerebral en- dothelium: a role in ischemic brain inflammation显示文摘 | Stanimirovic D Satoh K | 2000 | Brain Pathol2000，10，1： | 1 |
| 13 | Pathophysiology of the neurovascular unit:disease cause or consequence? 显示文摘 | Stanimirovic DB Friedman A | 2012 | J Cereb Blood Flow Metab2012，32，7： | 1 |
| 14 | Inflammatory mediators of eerebal endotheli-um : A role in ischemic brain inflammatinn 显示文摘 | Stanimirovic D Satoh K | 2000 | Brain Pathol2000，10，1： | 1 |
| 15 | In vitro evaluation of the clastogenicity of fumagillin显示文摘 | Stevanovic J Stanimirovic Z Radakovic M | 2008 | Environ Mol Mutagen2008，49，8： | 1 |
| 16 | On the generalized inverse and generalized resolvent显示文摘 | Djordjevic D S Stanimirovic P S | 2001 | Czechoslovak Math J2001，51，126： | 1 |
| 17 | Inflammatory gene transcription in human astrocytes exposed to hypoxia:Roles of the nuclear factor-κB and autocrine stimulation显示文摘 | Stanimirovic D Zhang W Howlett C | 2001 | J Neuroimmunol2001，119，2： | 1 |
| 18 | Inflammatory mediators of cerebral endothelium: a role in ischemic brain inllammation显示文摘 | Stanimirovic D Satoh K | 2000 | Brain Pathol2000，10，1： | 1 |
| 19 | Interaction between histamine and adenosine in human cerebromicrovascular endothelial cells: modulation of second messengers显示文摘 | STANIMIROVIC D B BERTRAND N MERKEL N | 1994 | Metab Brain Dis1994，9，3： | 1 |
| 20 | The induction of ICAM-1 in human cerebromicvascular endothelial cells by ischemia-like condtion promotes enhanced neutrophil/HCEC adhesion显示文摘 | Shapiro A Wong J | 1997 | J Neuroimmunol1997，，12： | 1 |
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