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| 1 | Effects of octreotide on acute necrotizing pancreatitis in rabbits显示文摘AIM: To assess the role of oxygen-derived free radicals and cytokines in the pathogenesis of taurocholic acid-induced acute pancreatitis, and to evaluate the preventive effects of octreotide towards the development of acute pancreatitis. METHODS: Acute pancreatitis was induced in male New Zealand white rabbits by retrograde injection of 0.8 mL/kg·b·m, of 50 g/L sodium taurocholate(NaTC) in the pancreatic duct. Sham-operated animals served as control. Octreotide 1 mglkg·b.m.was administered subcutaneously before the induction of pancreatitis. Blood was taken from the jugular vein before and at 1, 3, 6, 12 and 24 h after pancreatitis induction.Serum activities of amylase, IL-6 and TNF-α and levels of malonyl dialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), catalase and superoxide dismutase (Mn-,Cu-,and Zn-SOD) in pancreatic tissue were measured.RESULTS: Serum TNF-α and IL-6 levels increased significantly 3 h after the onset of pancreatitis, and then returned to control level. The tissue concentration of MDA was significantly elevated at 24 h, while the GSH level and GP-x, catalase, Mn-SOD, Cu-, Zn-SOD activities were all significantly decreased in animals with pancreatitis as compared to the control. Octreotide pretreatment significantly reversed the changes in cytokines and reactive oxygen metabolites. Octreotide treatment did not alter the serum amylase activity and did not have any beneficial effects on the development of histopathological changes.CONCLUSION: Oxygen-derived free radicals and proinflammatory cytokines are generated at an early stage of NaTc-induced acute pancreatitis in rabbits. Prophylac ticoctreotide treatment can prevent release of cytokines and generation of reactive oxygen metabolites, but does not have any beneficial effects on the development of necrotizing pancreatitis. | Lászl6Czakó PéterHegyi TamásTakács CsabaGóg AndrásFarkas YvetteMándy Ilona Sz.Varga LászlóTiszlavicz JánosLonovics | 2004 | World Journal of Gastroenterology2004，10，14： | 21 |
| 2 | L-arginine-induced experimental pancreatitis显示文摘Despite medical treatment, the lethality of severe acute pancreatitis is still high (20-30%). Therefore, it is very important to find good animal models to characterise the events of this severe disease. In 1984, Mizunuma et. al. developed a new type of experimental necrotizing pancreatitis by intraperitoneal administration of a high dose of L-arginine in rats. This non-invasive model is highly reproducible and produces selective, dose-dependent acinar cell necrosis.Not only is this a good model to study the pathomechanisne of acute necrotizing pancreatitis, but it is also excellent to observe and influence the time course changes of the disease. By writing this review we iluminate some new aspects of cell physiology and pathology of acute necrotizing pancreatitis. Unfortunately, the reviews about acute experimental pancreatitis usually did not discuss this model.Therefore, the aim of this manuscript was to summarise the observations and address some challenges for the future in L-arginine-induced pancreatitis. | PéterHegyi ZoltánRakonczayJr RékaSári CsabaGóg JánosLonovics TamásTakács LászlóCzakó | 2004 | World Journal of Gastroenterology2004，10，14： | 7 |
| 3 | Ferrite particles: a super-paramagnetic MR contrast agent for the reticuloendothelial system 显示文摘 | Saini S Stak D Hahn P | 1987 | Radiology1987，162，： | 1 |
| 4 | Phase Ⅰ clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent:safety,pharmacokinetics,and MR imaging显示文摘 | Hamm B Staks T Mühler A | | 0，，03： | 1 |
| 5 | Tumor necrosis factor 显示文摘 | Stak M Wilson AG Diff GW | 1995 | Lancet1995，345，： | 1 |
| 6 | A new Superparamagnetic Iron Oxide Contrast Agent for Magnetic Resonance Imaging显示文摘 | Hamm B Staks T Taupitz M | 1994 | Invest Radiol1994，29，： | 1 |
| 7 | Phase clinical evaluation of Gd EOB DTPA as a hepatobiliary MR contrast agent: safety, pharma cnkinetics,and MR imaging显示文摘 | Hamm B Staks T Muhler A | 1995 | Radiology1995，195，3： | 1 |
| 8 | Effects of Caerulein on the normal pancreas and on experimental pancreatic carcinoma in the syiam golden namster显示文摘 | STAK K MUKAI K UMEYAMA K | 1986 | Pancreas1986，1，： | 1 |
| 9 | Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging 显示文摘 | Hamm B Staks T MfihlerA | 1995 | Radiology1995，195，3： | 1 |
| 10 | Phase Ⅰ clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent:safety,pharmacokinetics,and MR imaging显示文摘 | Hamm B Staks T Mühler A | 1995 | Radiology1995，195，3： | 1 |
| 11 | Tennis in juries:occurrence,aetiololgy,and prevention显示文摘 | Pluim B Stak J Windler N | | 0，，： | 1 |
| 12 | Contrast-enhanced MR imaging of liver and spleen first experience in human with a new superparamagnetic iron oxide 显示文摘 | Hamm B Staks T Tsupitz M | 1994 | J Magn Reson Imaging1994，4，： | 1 |
| 13 | Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging 显示文摘 | Hamm B Staks T Muhler A | 1995 | Radiology1995，195，3： | 1 |
| 14 | Phase I clinical evaluation of Gd EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics,and MR imaging显示文摘 | Hamm B Staks T Muhler A | 1995 | Radiology1995，195，3： | 1 |
| 15 | Contrast-enhanced MR imaging of liver and spleen:first experience in human with a new superparamagnetic iron oxide显示文摘 | Hamm B Staks T Tsupitz M | 1994 | J Magn Reson Imaging1994，4，2： | 1 |
| 16 | Phase I chinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: Safety, pharmacokinetics and MR imaging显示文摘 | Hamm B Staks T Mtihler A | 1995 | Radiology1995，195，3： | 1 |
| 17 | Phase I clinical evalua- tion of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging显示文摘 | Harem B Staks T Muhler A | 1995 | Radiology1995，195，： | 1 |
| 18 | Evaluatbn of Pancreatic Exocrine Function by Secretin-Enhanced Magnetic Resonance Cholangiopancreatography显示文摘 | László Czakó János Endes TamásTakács | 2001 | Pancreas2001，23，： | 1 |
| 19 | Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent:safety,pharmacokinetics,and MR imaging显示文摘 | Hamm B Staks T Mühler A | 1995 | Radiology1995，195，： | 1 |
| 20 | Phase I clinical evaluation o{ Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetis, and MR imaging显示文摘 | H amm B Staks T Mi:hler A | 1995 | Radiology1995，195，3： | 1 |
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