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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Use of antibiotics in broiler production:Global impacts and alternatives显示文摘Antibiotics are used to fight bacterial infections.However, a selective pressure gave rise to bacteria resistant to antibiotics.This leaves scientists worried about the danger to human and animal health.Some strategies can be borrowed to reduce the use of antibiotics in chicken farms.Much research has been carried out to look for natural agents with similar beneficial effects of growth promoters.The aim of these alternatives is to maintain a low mortality rate, a good level of animal yield while preserving environment and consumer health.Among these, the most popular are probiotics, prebiotics, enzymes,organic acids, immunostimulants, bacteriocins, bacteriophages, phytogenic feed additives, phytoncides,nanoparticles and essential oils. | Youcef Mehdi Marie-Pierre Létourneau-Montminy Marie-Lou Gaucher Younes Chorfi Gayatri Suresh Tarek Rouissi Satinder Kaur Brar Caroline Cté Antonio Avalos Ramirez Stéphane Godbout | 2018 | Animal Nutrition2018，，2： | 19 |
| 3 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 4 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 5 | Aortic Stiffness Is an Independent Predictor of Fatal Stroke in Essential Hypertension显示文摘 | Stéphane Laurent Sandrine Katsahian Céline Fassot Anne-Isabelle Tropeano Isabelle Gautier Brigitte Laloux Pierre Boutouyrie | 2003 | Stroke: Journal of the American Heart Association2003，，5： | 2 |
| 6 | Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis显示文摘 | StéphaneQuideau DenisDeffieux CélineDouat‐Casassus LaurentPouységu | 2011 | Angew Chem Int Ed2011，，3： | 2 |
| 7 | New way to guide light 显示文摘 | J C Night P St Russell | 2002 | Science2002，296，： | 2 |
| 8 | Crystal structures and cation distributions in simple spinels from powder XRD structural refinements:MgCr2O4,ZnCr2O4,Fe3O4 and the temperature dependence of the cation distribution in ZnAl2O4显示文摘 | O'Neill H St C Dollase W A | 1994 | Phys Chem Miner1994，20，8： | 1 |
| 9 | Burnout among Hospital Nurses in China显示文摘 | Lin F St John W McVeigh C | 2009 | J Nurs Manag2009，17，3： | 1 |
| 10 | Endlessly single-mode photonic crystal fiber显示文摘 | BIRKS T A KNIGHT J C RUSSELL P St J | 1997 | Opt Lett1997，22，96： | 1 |
| 11 | The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs 显示文摘 | Khan M A Herzog C A Peter J V St | 1998 | N Engl J Med1998，339，11： | 1 |
| 12 | Endlessly single-mode photonic crystal fiber显示文摘 | Birks T A Knight J C Russell P St J | 1997 | Opt Lett1997，22，13： | 1 |
| 13 | Comparison of three probability formulae for parentage exclusion显示文摘 | Jamieson A Taylor St C S | 1997 | Animal Genetics1997，28，： | 1 |
| 14 | Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1显示文摘 | Smiley ST Reers M Mottola-Hartshorn C | 1991 | Proc Natl Acad Sci USA1991，88，9： | 1 |
| 15 | All si-lica single-mode optical fiber with photonic crystal cladding显示文摘 | Knight J C Birks T A Russell P St J | 1996 | Optics Letters1996，21，19： | 1 |
| 16 | Experimental petrochemistry of some highly siderophile elements at high temperatures, and some implication for ore formation and the mantles early history显示文摘 | ONEILL H ST C DINGWELL D B BORISOV A | 1995 | Chem Geol1995，120，： | 1 |
| 17 | All-silica single-mode optical fiber with photonic crystal cladding显示文摘 | KNIGHT J C BIRKS T A RUSSELL P St J | 1996 | Opt Lett1996，21，19： | 1 |
| 18 | Comparison of sufentanil versusfentanyl in ventilated term neonates显示文摘 | Schmidt B Adelmann C St utzer H | 2010 | KIin Padiatr2010，222，2： | 1 |
| 19 | Diffusionthrough CaSC>4 formed during the reaction of CaO withS02and 02显示文摘 | Hsia C? St Pierre GR Raghunathan K | 1993 | AIChE Journal1993，39，4： | 1 |
| 20 | Laparoscopic versus open inguinal hernia repair in pediatric patients: a systematic review显示文摘 | Esposito C St Peter SD Escolino M | 2014 | J Laparoendosc Adv Surg Tech A2014，24，11： | 1 |
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