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| 1 | Antioxidant and antimutagenic activities of bark extract of Terminalia arjuna显示文摘Objective:The alcoholic extract of stem bark of Terminalia arjuna(ALTA) was screened for antioxidant and antimutagenic(anticlastogenic) activity.Methods:Antioxidant property was determined by l,l,Diphynyl,2-Picryl hydrazyl(DPPH) assay,super oxide radical scavenging activity,lipid peroxidation assay and total polyphenolic content was determined by Folin-Ciocalteau’s reagent.Antimutagenic activity was evaluated using micronucleus test in mice. Results:The ALTA has shown potent antioxidant activity with EC50 of 2.491±0.160,50.110±0.150 & 71.000±0.250 in DPPH assay,superoxide radical scavenging activity and lipid peroxidation assay, which is comparable with ascorbic acid with EC50 of 2.471±0.140,40.500±0.390 and 63.000±0.360 respectively.In micronucleus test,ALTA(100 & 200 mg/kg,p.o.) showed significant reduction in percentage of micronucleus in both polychromatic erythrocytes(PCE) and normochromatie erythrocytes(NCE) and also shown significant reduction in P/N ratio.Conclusions:These results suggested that ALTA possess significant antioxidant and antimutagenic activity. | Gollapalle Lakshminarayana shastry Viswanatha Santosh Kumar Vaidya Ramesh C Nandakumar Krishnadas Srinath Rangappa | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 9 |
| 2 | 印度草药方NR/CAL/06的甲醇提取物对卵巢切除大鼠的抗骨质疏松作用(英文)显示文摘目的:证实印度草药方NR/CAL/06的甲醇提取物对卵巢切除大鼠的抗骨质疏松作用。方法:雌性Sprague-Drawley大鼠在无菌状态下行双侧卵巢切除术后被分为5组(n=10)。检测NR/CAL/06的甲醇提取物(200和400mg/kg口服)的抗骨质疏松作用并以雷洛昔芬(5.4mg/kg口服)作为标准对照药,治疗时间为90d。实验前后测量各组大鼠的体质量、卵巢质量、骨质量、骨矿物质含量、骨强度,血清及尿液中的钙、磷含量及血清碱性磷酸酶含量。电镜下观察大鼠股骨外径、长度及厚度。结果:双侧卵巢切除术后,大鼠骨质量、骨矿物质含量及骨强度均有下降;电镜观察到卵巢切除大鼠股骨骨质疏松、多孔、破碎,且骨长度及厚度均有所下降。与假手术组相比,卵巢切除大鼠的血清钙、磷及碱性磷酸酶含量均有所升高,体质量及脂肪含量升高,子宫质量降低。NR/CAL/06的甲醇提取物(200和400mg/kg口服)治疗90d能够剂量依赖性地改变大鼠因卵巢切除所引起的上述各项指标变化,并将骨质量、骨矿物质含量、骨强度,血清钙、磷及碱性磷酸酶含量,体质量及脂肪含量恢复至正常水平。此外,经NR/CAL/06的甲醇提取物(200和400mg/kg口服)治疗的大鼠与卵巢切除模型组大鼠相比,电镜下股骨骨质孔形成减少,骨密度增加。结论:本实验的结果证实了NR/CAL/06的甲醇提取物具有很好的抗骨质疏松作用,可用于骨质疏松症的治疗。 | Praveen Srikanta Shivaprasad H.Nagarajappa Gollapalle L.Viswanatha. Mukund Handral Rajesh Subbanna Rangappa Srinath Ganesh Hiremath | 2011 | 中西医结合学报2011，9，10： | 2 |
| 3 | Antidiarrheal effect of fractions from stem bark of Thespesia populnea in rodents:Possible antimotility and antisecretory mechanisms显示文摘Objective:To evaluate antidiarrheal activity of the fractions of aqueous extract from stem barks of Thespesia populnea(Malvaceae).Methods:From the aqueous extract three fractions namely ethyl acetate fraction(EAF),methanolic fraction(MF) and residue fraction(RF) were made and stuthed for antidiarrheal activity.Antidiarrheal activity of the fractions were evaluated in castor oil induced diarrhea,prostaglandin E2(PG-E2) induced diarrhea and charcoal meal test as in vivo models and the most potent fraction was further evaluated with in vitro models to determine the possible antimotility effect.Results:In castor oil induced diarrhea model,the RF(10,25,50 and 100 mg/kg,po.) and MF(100 mg/kg,po.) has significantly reduced the cumulative wet faecal mass,where as the EAF have not shown any significant antidiarrheal activity,RF was found to be more potent than MF.Based on these results and percentage yield,only RF was evaluated in PGE2 induced enteropooling and charcoal meal test.RF(10,25 and 50 mg/kg) had shown significant inhibition of PG-E2 induced secretions(antisecretory) and decreased the movement of charcoal in charcoal meal test indicating its antimotility activity.Furthermore,RF has showed significant inhibition of acetylcholine,histamine and BaCl2 induced contractions on rat colon,guinea pig ileum and rabbit jejunum with EC50 values of 241.7,303.1 and 286.1μg/mL,respectively indicating the antimotility effect of RF.The phytochemical analysis of RF showed presence of gums and mucilages and the possible mechanism may be the combination inhibition of elevated prostaglandin biosynthesis and reduced propulsive movement of the intestine.Conclusions: RF possesses good antidiarrheal activity comparing with other two fractions and the possible mechanism thought to be associated with combination of antisecretory and antimolity. | Gollapalle Lakshminaraya Shastry Viswanatha Shylaja Hanumanthappa Nandakumar Krishnadas Srinath Rangappa | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 1 |
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