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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Oestrogen-androgen crosstalk in the pathophysiology oferectile dysfunction显示文摘Ageing in man is associated with a decline in testosterone following changes in the hypothalamo-pituitary-testicular axis. This may offset the physiologic equilibrium between oestrogen and androgen and at some point when the ratio of free testosterone to oestradiol reaches a critical level, the oestrogenic gonadotropin suppressive effect predominates with decreased release of FSH and LH. Adding to this endocrinal complexity is the continued peripheral conversion to oestradiol through aromatisation. Although the androgen deficiency is not the sole cause for impotence in the elderly, there is a gradual decrease in nocturnal penile tumescence (NPT) and spontaneous morning erections with ageing. Despite the age related increase in oestrogen levels, the information on the pathophysiological role of the 'female hormone' in erectile dysfunction has been scanty. Together with our identification of oestrogen receptors within the penile cavernosum, we have delineated dysfunctional changes on male erection mediated by oestradiol.These findings parallel the recent concerns over environmental oestrogens on fertility declines in young men. Oestrogenic activity is also present in plants and thereby in human diet. These phytoestrogens are structurally and functionally similar to oestradiol and more potent than the environmental oestrogenic chemicals such as organochlorine and phenolic compounds. Thus in the light of growing concerns of possible compromising effects on sexuality by endogenous and environmental oestrogens, we are faced with the scientific need to delineate their role on the mechanism of male erectile pathway in health and disease for clinical correlates and prognostics. | B Srilatha PG Adaikan | 2003 | Asian Journal of Andrology2003，5，4： | 6 |
| 3 | Endocrine milieu and erectile dysfunction: is oestradio-testosterone imbalance, a risk factor in the elderly?显示文摘雌激素不对女性独占,但是在 25-70 的中等传播层次发生; pg 在男人的 ml −1 ,与 44-153 相比; pg 在女人的 ml −1 。从睾丸激素(T) 的 aromatisation 产生,雌激素被认为有许多在变老的男性反对生理的功能和进步 T 衰落与浆液 oestradiol 的相对或绝对的增加被联系(E 2) 。性公正和可勃起的机能障碍(编辑) 在老很可能由于 pathophysiological E 2-T 不平衡;改变的神经质的比率可以也向 environmental/plant 雌激素在 hyperestrogenism 或后面的暴露解释编辑的更高的发生。 | Balasubramanian Srilatha P Ganesan Adaikan | 2011 | Asian Journal of Andrology2011，13，4： | 5 |
| 4 | Effect of frequency on seismic response of reinforced soil slopes in shaking table tests显示文摘 | N. Srilatha G. Madhavi Latha C.G. Puttappa | 2013 | Geotextiles and Geomembranes2013，，： | 2 |
| 5 | Esterification of free fatty acids for biodiesel production over heteropoly tungstate supported on niobia catalysts 显示文摘 | Srilatha K Lingaiah N | 2009 | Applied Catalysis A: General2009，365，1： | 1 |
| 6 | Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1显示文摘 | Jennifer A Whitaker Nadine G Rouphael Srilatha Edupuganti Lilin Lai Mark J Mulligan | 2012 | The Lancet Infectious Diseases2012，，12： | 1 |
| 7 | Efficient ester- ification and transesterification of used cooking oil using 12-tungstophosphoric acid ( TPA)/Nb205 catalyst 显示文摘 | Srilatha K Issariyakul T Lingaiah N | 2010 | Energy Fuels2010，24，9： | 1 |
| 8 | Design of a natural laminar flow airfoil for a light aircraft显示文摘 | Srilatha K R Dwarakanath G S | 1990 | Journal of Aircraft1990，27，11： | 1 |
| 9 | Fungal pretreatment of orange processing waste by solid state fermentation for improved production of methane显示文摘 | SRILATHA H R NAND K SUDHAKAR BABU K | 1995 | Process Biochemistry1995，30，4： | 1 |
| 10 | Reattachment of fractured anterior teeth determining fracture strength using different techniques:an in vitro study显示文摘 | Srilatha Joshi S Chhasatia N | 2012 | J Contemp Dent Pract2012，13，1： | 1 |
| 11 | Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pilot study 显示文摘 | Srilatha B Adaikan P G Moore P K | 2006 | Eur J Pharmacol2006，535，13： | 1 |
| 12 | Sodium-Hydrogen Exchanger Regulatory Factor-1 Inter- acts with Mouse Urate Transporter 1 to Regulate Renal Proximal Tubule Uric Acid Transport 显示文摘 | Rochelle Cunningham Marc Brazie Srilatha Kanumuru | 2007 | American Society of Nephrology2007，，18： | 1 |
| 13 | Efficient esterification and transesterification of used cooking oil using 12-tungstophosphoric acid(TPA)/Nb2O5 catalyst显示文摘 | Srilatha K Issariyakul T Lingaiah N | 2010 | Energy Fuels2010，24，： | 1 |
| 14 | Functional analysis and screening small molecules to RpfF protein in Xanthomonas oryzae involved in rice bacterial blight disease显示文摘Xanthomonas oryzae pv.oryzae(Xoo) is an important rice pathogen.This is a vascular pathogen entering the plant via the hydathodes causing rice bacterial blight.It has been known that most regulation of pathogenicity factor F(RpfF) genes in Xanthomonas regulates virulence in response to the diffusible signal factor(DSF).The RpfF recognized as an attractive drug target in bacterial rice blight disease.In this study,we performed the gene-gene interaction of RpfF and pathway functional analysis.3 D structure of RpfF protein was predicted using a homology modelling tool Swiss-Model and refined by molecular dynamics(MD) simulation.The refined model protein was predicted structural assessment using various tools such as PROCHECK,ERRAT,and VERIFY-3 D.We have collected 2 500 rifampicin analogues from Zinc Database by virtual screening.The screened compounds were docked into the active site of the RpfF protein using AutoDock Vina in PyRx Virtual Screening Tool.Furthermore,docking result and in silico ADMET analysis described that the compounds ZINC03056414,ZINC03205310,ZINC08673779,ZINC09100848,ZINC09729566,ZINC11415953,ZINC12810788,ZINC24989313,ZINC27441787 and ZINC32739565 have best binding energies and less toxicity than reference compound.This study revealed that the active site residues such as HIS-118,HIS-147,THR-148,ARG-179,ASP-207,ARG-240 and THR-244 are key roles in the pathogenicity.It could be beneficial in the design of small molecule therapeutics or the treatment of rice bacterial blight disease. | Mundla Srilatha Naina Patyal Madhu Sudhana Saddala | 2020 | Journal of Integrative Agriculture2020，19，3： | 1 |
| 15 | Experimental models for the study of female and male sexual function 显示文摘 | Giuliano F Pfaus J Srilatha B | 2010 | J Sex Med2010，7，9： | 1 |
| 16 | Hair Dye Related Acute Kidney Injury – A Clinical and Experimental Study显示文摘 | Yanala Sandeep Reddy Shaik Abbdul Nabi Chippada Apparao Chinthamaneni Srilatha Yadla Manjusha Parvathina Sri Ram Naveen Chennu Krishna Kishore Anappindi Sridhar Vishnubotla Siva Kumar | 2012 | Renal Failure2012，，7： | 1 |
| 17 | Effect of al- pha-lipoic acid and vitamin E in diet on the performance, an- tioxidation and immune response in broiler chicken显示文摘 | Srilatha T Reddy R V Qudratullah S | 2010 | Inter- national Journal of Poultry Science2010，9，7： | 1 |
| 18 | A Cost-Effectiveness Analysis of Strategies for Controlling Japanese Encephalitis in Andhra Pradesh,India显示文摘 | Julie J Srilatha S | 2006 | Journal of Pharmaceutical Finance Economics & Policy2006，15，1： | 1 |
| 19 | Efficient esterification and transesterification of used cooking oil using 12-tungstophosphoric acid(TPA)/Nb2O5catalyst显示文摘 | Srilatha K Issariyakul T Lingaiah N | 2010 | Energy Fuels2010，24，： | 1 |
| 20 | Sexual dysfunction related to antihypertensive agents:Results from the animal model显示文摘 | Srilatha B Adaikan PG Arulkumaran S | 1999 | Int J Impot Res1999，11，： | 1 |
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