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| 1 | Role of bisphosphonates in the management of acute Charcot foot显示文摘Diabetes mellitus is the most common cause of Charcot neuropathy affecting foot and ankle. Acute Charcot foot(CF) presents with a red and swollen foot in co-ntrast to the painless deformed one of chronic CF. En-hanced osteoclastogenesis plays a central role in the pathogenesis of acute CF. Many studies have shown elevated levels of bone turnover markers in patients with acute CF confirming it. These findings have led cl-inicians to use anti-resorptive agents [bisphosphonates(BP), calcitonin, and denosumab] along with immobi-lization and offloading in acute CF patients. The ma-ximum evidence among all anti-resorptive agents is available for BPs, although its quality is low. Pamidronate has been shown to reduce the markers of activity of CF like raised skin temperature, pain, edema, and bone turnover markers in the majority of studies. Intravenous BPs are known to cause acute phase reactions leading to flu-like illness following their first infusion, which can be ameliorated by oral acetaminophen. Alendronate is the only oral BP used in these patients. It needs to be taken on an empty stomach with a full glass of water to avoid esophagitis. The side-effects and contraindications to BPs should be kept in mind while treating acute CF patients with them. | Harsh Durgia Jayaprakash Sahoo Sadishkumar Kam-alanathan Rajan Palui Kalyani Sridharan Henith Raj | 2018 | World Journal of Diabetes2018，9，7： | 9 |
| 2 | Corrosion and stress corrosion cracking in supercritical water显示文摘 | G.S. Was P. Ampornrat G. Gupta S. Teysseyre E.A. West T.R. Allen K. Sridharan L. Tan Y. Chen X. Ren C. Pister | 2007 | Journal of Nuclear Materials2007，，1： | 5 |
| 3 | Ionotropic receptors and ion channels in ischemic neuronal death and dysfunction显示文摘到神经原的精力供应的损失在击期间导致被称为缺氧的去极的膜潜力的快速的损失。因为离子的流动的 dysregulation 和 ATP 的损失,缺氧的去极在神经原上导致巨大的生理的应力驾驶维持电气化学的坡度的离子泵。在这评论,我们在场一些被认为贡献神经原并且随后的缺氧的去极的 ionotropic 受体和离子隧道的概述,到房间死亡。为作为门 ligand 的阳离子隧道工作的 glutamate 和 ATP 的 ionotropic 受体在神经原的死亡和机能障碍是批评的。有趣地,二这些受体(P2X7 和 NMDAR ) 被显示了联合离子隧道到 pannexin-1 (Panx1 ) 。我们也讨论短暂受体潜力(TRP ) 的重要角色响应局部缺血的隧道和酸察觉到的离子隧道(ASIC ) 。从我们缺氧的去极的当前的理解出现的中央挑战是需要阐明这些离子隧道到的机械学、时间的相互关系充分在击期间在神经原上欣赏他们的影响。 | Nicholas L WEILINGER Valentyna MASLIEIEVA Jennifer BIALECKI Sarup S SRIDHARAN Peter L TANG Roger J THOMPSON | 2013 | Acta Pharmacologica Sinica2013，34，1： | 5 |
| 4 | Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung显示文摘The Hippo/Yap pathwayis a wll-conserved signaling cascade that regulates cell proliferation and dfferentiationto control organsize and stem/progenitor cell behavior.Following airway injury,Yap was dynamically regulated in regenerating airway epithelial clls.To deter.mine the role ofHippo signaling in the lung,the mammalian Hippo kinases,Mst1 and Mst2,were deleted in epithelial cells ofthe embry-onic and mature mouse lung.Mst1/2 deletion in the fetal lung enhanced proliferation and inhibited sacculation and epithelial cell differentiation.The transcriptional inhibition of cell proliferation and activation of differentiation during normal perinatal lung maturation were inversely regulated followving embryonic Mst1/2 deletion.Ablation of Mst1/2 from bronchiolar epithelial cells in the adult lung caused airway hyperplasia and altered differentiation.Inhibitory Yap phosphorylation was decreased and Yap nuclear localization and transcriptional targets were increased after Mst1/2 deletion,consistent with canonical Hippo/Yap signaling.YAP potentiated cell prolif-eration and inhibited dfferentiation of human bronchial epithelial cells in vitro.Loss of Mst1/2 and expression ofYAP regulated transcrip-tional targets controlling cell proliferation and diferentiation,including Ajuba LIM protein.Ajuba was required forthe effects ofYAP oncell proliferation in vitro.Hippo/Yapsignaling regulates Ajuba and controls proliferation and diferentiation oflung epithelial progenitor cells. | Alexander W.Lange Anusha Sridharan Yan Xu Barry R.Stripp Anne-Karina Perl Jeffrey A.Whitsett | 2015 | Journal of Molecular Cell Biology2015，7，1： | 4 |
| 5 | Corrosion behavior of ferritic–martensitic steel T91 in supercritical water显示文摘 | Yun Chen Kumar Sridharan Todd Allen | 2005 | Corrosion Science2005，，9： | 3 |
| 6 | Space radiation and cardiovascular disease risk显示文摘Future long-distance space missions will be associated with significant exposures to ionizing radiation,and the health risks of these radiation exposures during manned missions need to be assessed. Recent Earth-based epidemiological studies in survivors of atomic bombs and after occupational and medical low dose radiation exposures have indicated that the cardiovascular system may be more sensitive to ionizing radiation than was previously thought. This has raised the concern of a cardiovascular disease risk from exposure to space radiation during long-distance space travel. Groundbased studies with animal and cell culture models play an important role in estimating health risks from space radiation exposure. Charged particle space radiation has dense ionization characteristics and may induce unique biological responses,appropriate simulation of the space radiation environment and careful consideration of the choice of the experimental model are critical. Recent studies have addressed cardiovascular effects of space radiation using such models and provided first results that aid in estimating cardiovascular disease risk,and several other studies are ongoing. Moreover,astronauts could potentially be administered pharmacological countermeasures against adverse effects of space radiation,and research is focused on the development of such compounds. Because the cardiovascular response to space radiation has not yet been clearly defined,the identification of potential pharmacological countermeasures against cardiovascular effects is still in its infancy. | Marjan Boerma Gregory A Nelson Vijayalakshmi Sridharan Xiao-Wen Mao Igor Koturbash Martin Hauer-Jensen | 2015 | World Journal of Cardiology2015，7，12： | 2 |
| 7 | Rectangular hyperbola method of consolidation analysis显示文摘 | Sridharan A Murthyand N S Prskash K | 1987 | Geotechnique1987，37，3： | 2 |
| 8 | Microstructural examination of oxide layers formed on an oxide dispersion strengthened ferritic steel exposed to supercritical water显示文摘 | Yun Chen Kumar Sridharan Todd R. Allen Shigeharu Ukai | 2006 | Journal of Nuclear Materials2006，，1： | 2 |
| 9 | An exploratory spatial data analysis approach to understanding the relationship between deprivation and mortality in Scotland显示文摘 | Sanjeev Sridharan Helena Tunstall Richard Lawder Richard Mitchell | 2007 | Social Science & Medicine2007，，9： | 2 |
| 10 | Seroprevalence of HCV and its co-infection with HBV and HIV among liver disease patients of South Tamil Nadu显示文摘AIM:To determine the seroprevalence of hepatitis C virus(HCV) and its co-infection with hepatitis B virus(HBV),hepatitis delta agent(HDV) and human immunodeficiency virus(HIV) among liver disease patients of south Tamil Nadu. METHODS:A total of 1012 samples comprising 512 clinically diagnosed cases of liver disease patients and 500 apparently healthy age and sex matched individuals were screened for Hepatitis C virus(anti HCV and HCV RNA) ,Hepatitis B virus(HBsAg),Hepatitis delta agent(anti HDV) and Human immuno virus(antibodies to HIV-1 and HIV-2) using commercially available enzyme linked immunosorbent assay kits.HCV RNA wasdetected by RT-PCR.Liver function tests like ALT,AST,GGT,ALP,bilirubin and albumin were also studied. RESULTS:The seroprevalence of HCV was found to be 5.6%among liver disease patients by ELISA.27/512,49/512 and 12/512 patients were positive for HIV,HBV &HDV respectively.Co-infection of HCV&HBV was found in 8 patients,with 6 for HCV&HIV and 4 for HCV,HBV&HIV co-infections.Sex-wise analysis showed that HIV,HCV&HBV and HCV&HIV co-infection was high among females whereas for HBV it was high in males. The mean ALT and AST in HCV positive cases were 42.1±8.3 and 49±10.1.In people co-infected with HCV&HBV or HCV&HIV or HCV,HBV&HIV the mean ALT of 58.0±03.16,56.78±4.401 and 64.37±4.01 respectively. CONCLUSION:We strongly recommend routine test of the blood for HCV in addition to HBV and HIV.We also recommend individualized counseling to identify those at risk and testing for those who want it.Improved surveillance and periodic epidemiological studies will have to be undertaken to monitor and prevent these blood-borne viruses. | Ganesh Kumar Anbazhagan Sridharan Krishnamoorthy Thirunalasundari Thiyagarajan | 2010 | World Journal of Hepatology2010，2，1： | 2 |
| 11 | Compressibility behaviour of remoulded, fine-grained soils and correlation with index properties显示文摘 | SRIDHARAN A NAGARAJ H B | 2000 | Canadian Geotechnical Journal2000，37，3： | 1 |
| 12 | Strength prediction of plain woven fabrics显示文摘 | KOLLEGA M G SRIDHARAN S | 2000 | Journal of Composite materials2000，34，3： | 1 |
| 13 | Projective generation of curves in polynomial extensions of an atone domain and a question of Nori 显示文摘 | Bhatwadekar S M Raja Sridharan | 1998 | Invent Math1998，133，1： | 1 |
| 14 | Rectangular Hyperbola Method of Consolidation Analysis显示文摘 | Sridharan A Murthyand N S Prskash K | 1987 | Geotechnique1987，37，3： | 1 |
| 15 | The collaboration index: a measure for supply chain collaboration 显示文摘 | Simatupang T M Sridharan R | 2005 | International Journal of PhysicalDistribution & Logistics Management2005，35，1： | 1 |
| 16 | Incidence,types, risk factors, and outcome of stroke in a developingcountry: the Trivandrum Stroke Registry 显示文摘 | Sridharan SE Unnikrishnan JP Sukumaran S | 2009 | Stroke2009，40，4： | 1 |
| 17 | Revenue management in or- der-driven production syatems显示文摘 | MEHMET B SRIDHARAN V | 2005 | Decision Sciences2005，36，2： | 1 |
| 18 | Swelling behavior of compacted fine-grained soils显示文摘 | SRIDHARAN A GURTUG Y | 2004 | Engineering Geology2004，72，1： | 1 |
| 19 | Performance evaluation of heat exchanger for mixed refrigerant J-T cryocooler显示文摘 | ARDHAPURKAR P M SRIDHARAN A ATREY M D | 2014 | Cryogenics2014，63，： | 1 |
| 20 | Versatile model for interactive buckling of columns and beam-columns显示文摘 | ALI M A SRIDHARAN S A | 1988 | International Journal of Solids and Structures1988，24，5： | 1 |
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