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8篇 您的检索式：作者名="Sponseller D L"

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		题名	作者	年代	出处	被引量
	1	Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD.	Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao	2017	Bone Research2017，5，1：	9
	2	The influence of molybdenum on the γ' phase in experimental nickel-base superalloys显示文摘	LOOMIS W T FREEMAN J W SPONSELLER D L	1972	Metallurgical Transactions1972，，3：	1
	3	Low-sulfur steels: production, properties and applications显示文摘	Sponseller D L Shawber C V V	1985	Journal of Metals1985，37，3：	1
	4	Effect of microstructure on sulfide-stress-cracking resistance of high strength casing steels显示文摘	Sponseller D L Garber R Straatman J A	1983	ASTM Technical Publi- cation 7921983，，：	1
	5	Development of higher strength H2S resistant steels for oil field applications显示文摘	Grobner P J Sponseller D L Cias W W	1975	Material Performance1975，14，6：	1
	6	035% Cb 显示文摘	Grobner P J Sponseller D L Diesburg D E Effect of Molyb- denum Content on the Sulfide Stress Cracking Resistance of AISI 4130-Type Steel With 0	1979	Corrosion1979，35，6：	1
	7	Development of clad boiler tubes extruded from bimetallic centrifugal castings显示文摘	Sponseller D L Timmons G A Bakker W T		0，，07：	1
	8	The influence of molybdenum on the T' phase in experimental nickle-base superalloys显示文摘	LOOMIS W T FREEMAN J W SPONSELLER D L	1972	Metallurgical Transations1972，，3：	1

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