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| 1 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 2 | Modes of ac-tion of the antagonist Aureobasidium pullulans PL5a-gainst postharvest pathogens of fruit:Production of hy-drolytic enzymes and competition for nutrients显示文摘 | Zhang D P Spadaro D Garibaldi A | 2010 | Bio-logical Control2010，54，： | 1 |
| 3 | State of the art and future prospects of the biological control of postharvest fruit diseases显示文摘 | SPADARO D GULLINO M L | 2004 | International Journal of Food Microbiology2004，91，： | 1 |
| 4 | Direct apoptotic effects of free fatty acids on human endothelial cells 显示文摘 | Piro S Spampinato D Spadaro L | 2008 | Nutr Metab Cardiovasc Dis2008，18，2： | 1 |
| 5 | State of the art and future prospects of the biological control of postharvest fruit diseases 显示文摘 | Spadaro D Gullino M L | 2004 | Journal d Food Microbiology2004，，91： | 1 |
| 6 | Mechanisms of action and efficacy of four isolates of the yeast Metschnikowia pulcherrima active against postharvest pathogens on apples显示文摘 | Spadaro D Vola R Piano S Gullino M L | 2002 | Postharvest Biol & Technol2002，24，： | 1 |
| 7 | Selection and evaluation of new antagonists for their efficacy against postharvest brown rot of peaches显示文摘 | Zhang D P Spadaro D Garibaldi A | 2010 | Postharvest Biology and Technology2010，55，： | 1 |
| 8 | Efficacy of plant essential oils on posthar-vest control of rot caused by fungi on four cultivars ofapples in vivo显示文摘 | Jorge Giovanny Lopez-Reyes J G Spadaro D GullinoM L | 2010 | Flavour and Fragrance Journal2010，25，： | 1 |
| 9 | Screening andefficacy evaluation of three antagonists against post-harvest brown rot of peaches显示文摘 | Zhang D Spadaro D Garibaldi A | 2010 | Postharvest Biologyand Technology2010，55，： | 1 |
| 10 | Efficacy of the antagonist Aureobasidium pullulans PL5 against postharvest pathogens of peach, apple and plum and its modes of action 显示文摘 | ZHANG Dianpeng SPADARO D GARIBALDI A | 2010 | Biological Control2010，54，3： | 1 |
| 11 | An unusual case of a- cute respiratory failure in a patient with pulmonary veins steno- sis late after catheter ablation of atrial fibrillation: a case report and the review of the literature 显示文摘 | Spadaro S Saturni S Cadorin D | 2015 | BMC Pulmonary Medicine2015，15，128： | 1 |
| 12 | Direct apoptotic effects of free fatty acids on human endothelial cells显示文摘 | PIRO S SPAMPINATO D SPADARO L | 2008 | Nutr Metab Cardiovasc Dis2008，18，2： | 1 |
| 13 | Positioning of the RPR standard in contemporary operator environments显示文摘 | SPADARO S SOLE P J CAREGLIO D | 2004 | IEEE Network2004，18，2： | 1 |
| 14 | Direct apoptotic effects of free fatty acids on human endothelial cells 显示文摘 | Piro S Spampinato D Spadaro L | 2008 | Nutr Metab Cardiovasc Dis2008，18，： | 1 |
| 15 | Efficacy of plant essential oils on postharvest control of rot caused by fungi on four cultivars of apples in vivo显示文摘 | Lopez-Reyes J G Spadaro D Gullino M L Garibaldi A | | 0，，： | 1 |
| 16 | Potential of Two Metschnikowia pulcherrima (Yeast) Strains for In Vitro Biodegradation of Patulin显示文摘 | Reddy K R N Spadaro D Gullino M L Garibaldi A | 2011 | Journal of Food Protection2011，，1： | 1 |
| 17 | Efficacy of yeast antagonists used individually or in combination with hot water dipping for control of postharvest brown rot of peaches显示文摘 | Zhang J G Lopez-Reyes D Spadaro | 2010 | Journal of Plant Diseases and Pro- tection2010，117，5： | 1 |
| 18 | Silver anode treatment of chronic ostermyelitis显示文摘 | Webster D A Spadaro A J | 1981 | Clin Orthop Rel Res1981，161，： | 1 |
| 19 | State of the art and future prospects of the biological control of postharvest fruit diseases显示文摘 | SPADARO D GULLINO M L | 2004 | International Journal of Food Microbiology2004，91，2： | 1 |
| 20 | Control of soil borne pathogens of tomato using a commercial formulation of Strep tomyces griseoviridis and solarization 显示文摘 | Minuto A Spadaro D Garibaldi A | 2006 | Crop Protection2006，25，： | 1 |
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