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| 1 | Effect of alcohol consumption on liver stiffness measured by transient elastography显示文摘AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or continuation.METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver disease.TE was performed at least one week apart by senior operator.TE examinations with less than ten successful measures or with an interquartile range above 30% were excluded.We retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was available.Concomitant biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were recorded.Putative fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis C.Initial and final putative fibrosis score were compared according to alcohol consumption during follow-up.RESULTS:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two examinations.Thirty-seven patients met our criteria with a median follow-up of 32.5 wk.At the end of the study,13(35%) were abstinent,and 24(65%) relapsers.Eight patients had liver biopsy during follow-up.TE decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off value.In relapsers TE increased in 45% and decreased in 54% of patient.There was no statistical difference between initial and final TE in relapsers.In the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final TE.Using 19.5 kPa as cut-off for cirrhosis,7 patients had cirrhosis at initial TE and 5 patients had cirrhosis at final TE.Using 12.5 kPa as cut-off for cirrhosis,16 patients had cirrhosis at initial TE and 15 patients had cirrhosis at final TE.Evolution of biological data was in accordance with the relapse or abstinent status:abstinence ratio(duration of abstinence/duration follow-up) was correlated with AST ratio(r =-0.465,P = 0.007) and GGT ratio(r =-0.662,P<0.0001).GGT was correlated with initial(r = 0.488,P = 0.002) and final TE(r = 0.49,P<0.005).Final TE was correlated with AST(r = 0.362,P<0.05).Correlation between TE ratio and AST ratio(r = 0.44,P = 0.01) revealed that TE varied proportionally to AST for all patients irrespective of their alcohol status.The same relationship was observed between TE ratio and GGT ratio(r = 0.65,P<0.0001).Evolution of TE was significantly correlated with the ratio of time of abstinence to observation time(r =-0.387,P = 0.016) and the evolution of liver enzymes.CONCLUSION:TE significantly decreased with abstinence.Results of TE in alcoholic liver disease cannot be interpreted without taking into account alcohol consumption and liver enzymes. | Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot Dominique Guyader Romain Moirand | 2013 | World Journal of Gastroenterology2013，19，4： | 20 |
| 2 | Endoscopic ultrasound diagnostic gain over computed tomography and magnetic resonance cholang-iopancreatography in defining etiology of idiopathic acute pancreatitis显示文摘BACKGROUND About 10%-30%of acute pancreatitis remain idiopathic(IAP)even after clinical and imaging tests,including abdominal ultrasound(US),contrast-enhanced computed tomography(CECT)and magnetic resonance cholangiopancreatography(MRCP).This is a relevant issue,as up to 20%of patients with IAP have recurrent episodes and 26%of them develop chronic pancreatitis.Few data are available on the role of EUS in clarifying the etiology of IAP after failure of one or more cross-sectional techniques.AIM To evaluate the diagnostic gain after failure of one or more previous crosssectional exams.METHODS We retrospectively collected data about consecutive patients with AP and at least one negative test between US,CECT and MRCP,who underwent linear EUS between January 2017 and December 2020.We investigated the EUS diagnostic yield and the EUS diagnostic gain over different combinations of these crosssectional imaging techniques for the etiologic diagnosis of AP.Types and frequency of EUS diagnosis were also analyzed,and EUS diagnosis was compared with the clinical parameters.After EUS,patients were followed-up for a median of 31.5 mo to detect cases of pancreatitis recurrence.RESULTS We enrolled 81 patients(63%males,mean age 61±18,23%with previous cholecystectomy,17%with recurrent pancreatitis).Overall EUS diagnostic yield for AP etiological diagnosis was 79%(20%lithiasis,31%acute on chronic pancreatitis,14%pancreatic solid or cystic lesions,5%pancreas divisum,5%autoimmune pancreatitis,5%ductal abnormalities),while 21%remained idiopathic.US,CECT and MRCP,taken alone or in combination,led to AP etiological diagnosis in 16(20%)patients;among the remaining 65 patients,49(75%)obtained a diagnosis at EUS,with an overall EUS diagnostic gain of 61%.Sixty-eight patients had negative US;among them,EUS allowed etiological diagnosis in 59(87%).Sixty-three patients had a negative CECT;among them,47(74%)obtained diagnosis with EUS.Twenty-four had a negative MRCP;among them,20(83%)had EUS diagnosis.Twenty-one had negative CT+MRCP,of which 17(81%)had EUS diagnosis,with a EUS diagnostic gain of 63%.Patients with biliary etiology and without previous cholecystectomy had higher median values of alanine aminotransferase(154 vs 25,P=0.010),aspartate aminotransferase(95 vs 29,P=0.018),direct bilirubin(1.2 vs 0.6,P=0.015),gammaglutamyl transpeptidase(180 vs 48,P=0.006)and alkaline phosphatase(150 vs 72,P=0.015)Chronic pancreatitis diagnosis was more frequent in patients with recurrent pancreatitis at baseline(82%vs 21%,P<0.001).During the follow-up,AP recurred in 3 patients,one of which remained idiopathic.CONCLUSION EUS is a good test to define AP etiology.It showed a 63%diagnostic gain over CECT+MRCP.In suitable patients,EUS should always be performed in cases of IAP.Further prospective studies are needed. | Stefano Mazza Biagio Elvo Clara Benedetta Conti Andrea Drago Maria Chiara Verga Sara Soro Annalisa De Silvestri Fabrizio Cereatti Roberto Grassia | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，6： | 3 |
| 3 | 欧元将面临比希腊危机更大的考验显示文摘欧元缔造者之一的奥特马尔·伊辛正确地阐述了这种单一货币的创建原则。正如上周他在《金融时报》中所述,欧元的设计宗旨就是成为一个货币联盟,而非政治联盟。欧元各成员国建立了一个共同的中央银行,但是拒绝将对本国公民的征税权移交给一个共同的机构。这一原则被庄严弛载入《马斯特里赫特条约》,此后又被德国宪法法院赋予了严格的解释。 | George Soros 彭宏权 | 2010 | 英语文摘2010，，4： | 2 |
| 4 | Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines 显示文摘 | RANUCCI M BARYSHNIKOVA E SORO G | 2011 | Ann Thorac Surg2011，91，1： | 1 |
| 5 | Protection strategies during cardiopulmonary bypass: ventilation, anesthetics and oxygen显示文摘 | Carlos Ferrando Marina Soro Francisco J. Belda | 2015 | Current Opinion in Anaesthesiology2015，，1： | 1 |
| 6 | Lipolytic isoenzymes from euphorbia latex显示文摘 | Palocci C Soro S Cernia E | 2003 | Plant Sci2003，165，： | 1 |
| 7 | Conjoined lumbosacral nerve roots: current aspects of diagnosis显示文摘 | Bottcher J Petrovitch S Soros P | 2004 | Eur Spine J2004，13，： | 1 |
| 8 | A candidate gene study in low HDL-cholesterol families provides evidence for the involvement of the APOA2 gene and the APOA1C3A4 gene cluster 显示文摘 | Lilja HE Soro A Ylitalo K | 2002 | Atherosclerosis2002，164，1： | 1 |
| 9 | Endothelial function, carotid artery intima-media thickness, epicardial adipose tissue,and left ventricular mass and function in growth hormone-deficient adolescents:apparent effects of growth hormone treatment on these parameters 显示文摘 | Lanes R Soros A Flores K | 2005 | Clin Endocrinol Metab2005，90，7： | 1 |
| 10 | Cluster head election techniques for coverage preservation in wireless sensor networks显示文摘 | SORO S HEINZELMAN W B | 2009 | Elsevier Ad hoe Networks2009，7，5： | 1 |
| 11 | Metabolic syndrome aggravates the increased endothelial activation and low -grade in flam mation in subjects with familial low HDL显示文摘 | Soro - Paavonen A Westerbacka J Ehnholm C | 2006 | Ann Med2006，38，2： | 1 |
| 12 | Lipoprotein X in patients with cirrhosis: its relationship to cholestasis and hypercholesterolemia显示文摘 | Soros P Bottcher J Maschek H Selberg O Mailer M J | 1998 | Hepatology1998，28，： | 1 |
| 13 | Fenoldopam prophylaxis of postoperative acute renal failure in high-risk cardiac surgery patients 显示文摘 | RANUCCI M SORO G BARAZGHI N | 2004 | Ann Thorac Surg2004，78，4： | 1 |
| 14 | Normaothermic perfusion andlung function after cardiopulmonary bypass : effects in pulmonary riskpatients 显示文摘 | Ranucci M Soro G Frigiola A | 1997 | Per fusion1997，12，5： | 1 |
| 15 | Effect of aqueous extract of Persea americana seeds on the glycemia of diabetic rabbits 显示文摘 | N'guessan K Amoikon KE Soro D | 2009 | EurJSci Res2009，26，3： | 1 |
| 16 | The Crisis & The Euro显示文摘 | George Soros | 2010 | The New York Review of Books2010，，8： | 1 |
| 17 | Comeal endothelial cell loss after trabeculectomy or after phacoemulsifica- tion, IOL implantation and trabeculectomy in 1 or 2 steps显示文摘 | Soro Martinez MI Villegas Perez MP Sobrado Calvo P | 2010 | Graefe''s archive for clinical and experimental ophthalmology: Albrecht von Graefes Archiv fur klinische land experimentelle Opthalmologie2010，248，2： | 1 |
| 18 | Cardiovascular and neurological causes of sudden death after ischaemic stroke显示文摘 | SOROS P HACHINSKI V | 2012 | Lancet Neurol2012，11，2： | 1 |
| 19 | The role of the reaction medium in lipase-catalyzed esterificatlons and transesterifications显示文摘 | Cernia E Palocci C Soro S | 1998 | Chemistry and Physics of Lipids1998，，93： | 1 |
| 20 | Phantom sensations following acute pain 显示文摘 | Kneeht S Soros P Gtirtler S Imai T Ringelstein EB Henningsen H | 1998 | Pain1998，77，2： | 1 |
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