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1Superior mesenteric artery first approach versus standard pancreaticoduodenectomy: a systematic review and meta-analysis显示文摘BACKGROUND: The superior mesenteric artery(SMA) first approach was proposed recently as a new modification of the standard pancreaticoduodenectomy. Increasing evidence showed that a periadventiceal dissection of the SMA with early transection of the inflow during pancreaticoduodenectomy associates better early perioperative results, and setup the scene for long-term oncological benefits. The objectives of the current study are to compare the operative results and long-term oncological outcomes of SMA first approach pancreaticoduodenectomy(SMA-PD) with standard pancreaticoduodenectomy(S-PD).DATA SOURCES: Electronic search of the PubM ed/MEDLINE, EMBASE, Web of Science and Cochrane Library was performed until July 2015. We considered randomized controlled trials(RCTs) and non-randomized comparative studies(NRCSs) comparing SMA-PD with S-PD to be eligible if they included patients with periampullary cancers.RESULTS: A total of one RCT and thirteen NRCSs met the inclusion criteria, involving 640 patients with SMA-PD and 514 patients with S-PD. The SMA-PD was associated with less intraoperative bleeding, less blood transfusions and higher rate of associated venous resections. The pancreatic fistula and delayed gastric emptying had a significantly lower rate in the SMA-PD group. There were no differences between the two approaches regarding overall complications, major complication rates and in-hospital mortality. There was no difference regarding R0 resection rate, and one-, two-or three-year over-all survival. The SMA-PD was associated with a lower local, hepatic and extrahepatic metastatic rate.CONCLUSIONS: The SMA-PD is associated with better perioperative outcomes, such as blood loss, transfusion requirements, pancreatic fistula, and delayed gastric emptying. Although the one-, two-or three-year overall survival rate is not superior, the SMA-PD has a lower local and metastatic recurrence rate.Ionut Negoi Sorin Hostiuc Alexandru Runcanu Ruxandra Irina Negoi Mircea Beuran 2017Hepatobiliary & Pancreatic Diseases International2017,16,2:10
2Laparoscopic vs open complete mesocolic excision with central vascular ligation for colon cancer: A systematic review and meta-analysis显示文摘AIM To compare the effectiveness of laparoscopic complete mesocolic excision(CME) with central vascular ligation(L-CME) with its open(O-CME) counterpart. METHODS We conducted an electronic search of the Pub Med/MEDLINE, Excerpta Medica Database, Web of Science Core Collection, Cochrane Center Register of Controlled Trails, Cochrane Database of Systematic Reviews, Sci ELO, and Korean Journal databases from their inception until May 2017. We considered randomized controlled trials(RCTs) and controlled clinical trials(CCTs) that included patients with colonic cancer comparing L-CME and O-CME. Primary outcomes included the quality of the resected specimen(lymph nodes retrieved, complete mesocolic plane excision, tumor to arterial high tie, resected mesocolon surface). Secondary outcomes included the three-year and five-year overall and disease-free survival rates, recurrence of the disease, surgical data, and postoperative morbidity and mortality. Two authors of the review screened the methodological quality of the eligible trials and independently extracted data from individualstudies.RESULTS A total of one RCT and eleven CCTs(four from Europe and seven from Asia) met the inclusion criteria for the current meta-analysis. These studies involved 1619 patients in L-CME and 1477 patients in O-CME. The L-CME was associated with the same quality of the resected specimen, with no differences regarding the retrieved lymphnodes(MD =-1.06, 95%CI:-3.65 to 1.53, P = 0.42), and tumor to high tie distance(MD = 14.26 cm, 95%CI:-4.30 to 32.82, P = 0.13); the surface of the resected mesocolon was higher in the L-CME group(MD = 11.75 cm2, 95%CI: 9.50 to 13.99, P < 0.001). The L-CME was associated with a lower rate of blood transfusions(OR = 0.45, 95%CI: 0.27 to 0.75, P = 0.002), faster recovery of gastrointestinal function, and less postoperative overall complication rate. The L-CME approach was associated with a statistical significant better three-year overall(OR = 2.02, 95%CI: 1.31 to 3.12, P = 0.001, I2 = 28%) and disease-free(OR = 1.45, 95% CI: 1.00 to 2.10, P = 0.05, I2 = 0%) survival. CONCLUSION The laparoscopic approach offers the same quality of the resected specimen as the open approach in complete mesocolic excision with central vascular ligation for colon cancer. The laparoscopic complete mesocolic excision with central vascular ligation is superior in all perioperative results and at least non-inferior in long-term oncological outcomes.Ionut Negoi Sorin Hostiuc Ruxandra Irina Negoi Mircea Beuran 2017World Journal of Gastrointestinal Oncology2017,9,12:7
3Successful endovascular treatment in patients with acute thromboembolic ischemia of the lower limb including the crural arteries显示文摘AIM To examine the efficacy and safety of the 6 French(6F) Rotarex~S catheter system in patients with acute limb ischemia(ALI) involving thromboembolic occlusion of the proximal and mid-crural vessels.METHODS The files of patients in our department with ALI between 2015 and 2017 were examined. In seven patients, the Rotarex~S catheter was used in the proximal segment of the crural arteries. Data related to the clinical examination, Doppler sonography, angiography and followup from these patients were further used for analysis.RESULTS Two patients(29%) had thrombotic occlusion of the common femoral artery, and the remaining five exhibited thrombosis of the superficial femoral artery and popliteal artery. Mechanical thrombectomy was performed in all cases using a 6F Rotarex~S catheter. Additional Rotarex~S catheter thrombectomy due to remaining thrombus formation with no reflow was performed in the anterior tibial artery in two of seven cases(29%), in the tibiofibular tract and posterior tibial artery in two of seven cases(29%) and in the tibiofibular tract and fibular artery in the remaining three of seven cases(43%). Ischemic symptoms resolved promptly in all, and none of the patients experienced a procedural complication, such as crural vessel dissection, perforation or thrombus embolization.CONCLUSION Mechanical debulking using the 6F Rotarex~S catheter system may be a safe and effective treatment option in case of thrombotic or thromboembolic occlusion of the proximal and mid-portion of crural arteries.Sorin Giusca Dorothea Raupp Dirk Dreyer Christoph Eisenbach Grigorios Korosoglou 2018World Journal of Cardiology2018,10,10:7
4以用户为中心的新兴电力市场模式显示文摘随着可再生能源在现代能源产业中的占比不断提高,其对现行电力系统和电力市场的运行机制所带来的影响也日趋明显;同时,通过与数字信息产业深度结合,分布式能量管理手段也处于飞速发展阶段。在这二者的驱动下,一种以用户为中心的新兴电力市场模式正以不同的表现形式出现在世界各地。文章以高度概括的方式介绍了这一新兴电力市场模式,浅析了其在不同表现形式下的机理和特征。基于这一新兴电力市场模式在短期内所取得的发展成就,有理由相信此类新兴电力市场模式将逐步成为未来电力市场中的重要组成部分。Pierre Pinson Thomas Baroche Fabio Moret Tiago Sousa Etienne Sorin Shi You 2017供用电2017,34,12:6
5Platelet-to-lymphocyte ratio and CA19-9 are simple and informative prognostic factors in patients with resected pancreatic cancer显示文摘We read with great interest the paper “Combined preoperative platelet-to-lymphocyte ratio and serum carbohydrate antigen 19-9 level as a prognostic factor in patients with resected pancreatic cancer” published in Hepatobiliary & Pancreatic Diseases International [1].Ionut Negoi Mircea Beuran Sorin Hostiuc Alaa El-Hussuna Enrique de-Madaria 2019Hepatobiliary & Pancreatic Diseases International2019,18,3:4
6Using experimental data to reduce the single-building sigma of fragility curves:case study of the BRD tower in Bucharest,Romania显示文摘The lack of knowledge concerning modelling existing buildings leads to significant variability in fragility curves for single or grouped existing buildings.This study aims to investigate the uncertainties of fragility curves,with special consideration of the single-building sigma.Experimental data and simplified models are applied to the BRD tower in Bucharest,Romania,a RC building with permanent instrumentation.A three-step methodology is applied:(1)adjustment of a linear MDOF model for experimental modal analysis using a Timoshenko beam model and based on Anderson’s criteria,(2)computation of the structure’s response to a large set of accelerograms simulated by SIMQKE software,considering twelve ground motion parameters as intensity measurements(IM),and(3)construction of the fragility curves by comparing numerical interstory drift with the threshold criteria provided by the Hazus methodology for the slight damage state.By introducing experimental data into the model,uncertainty is reduced to 0.02 considering S d(f1)as seismic intensity IM and uncertainty related to the model is assessed at 0.03.These values must be compared with the total uncertainty value of around0.7 provided by the Hazus methodology.Matthieu Perrault Philippe Gueguen Alexandru Aldea Sorin Demetriu 2013Earthquake Engineering and Engineering Vibration2013,12,4:4
7Predictors of rebleeding and in-hospital mortality in patients with nonvariceal upper digestive bleeding显示文摘BACKGROUND Nonvariceal upper digestive bleeding (NVUDB) represents a severe emergency condition and is associated with significant morbidity and mortality. Despite a decrease in the incidence due to the widespread use of potent therapy with proton pump inhibitors as well as the implementation of modern endoscopic techniques, the mortality rate associated with NVUDB is still high. AIM To identify the clinical, biological, and endoscopic parameters associated with a poor outcome in patients with NVUDB to allow the stratification of risk, which will lead to the implementation of the most accurate management. METHODS We performed a retrospective study including patients who were admitted to the Gastroenterology Department of Clinical Emergency County Hospital Timisoara, Romania, with a diagnosis of NVUDB between 1 January 2008 and 31 December 2016. All the data were collected from the patient’s records, including demographic data, medication history, hemodynamic status, paraclinical tests, and endoscopic features as well as the methods of hemostasis, rate of rebleeding, need for surgery and death;we also assessed the Rockall score of the patients, length of hospitalization and associated comorbidities. All these parameters were evaluated as potential risk factors associated with rebleeding and death in patients with NVUDB.RESULTS We included a batch of 1581 patients with NVUDB, including 523 (33%) females and 1058 (67%) males with a median age of 66 years. The main cause of NVUDB was peptic ulcer (73% of patients). More than one-third of the patients needed endoscopic treatment. Rebleeding rate was 7.72%;surgery due to failure of endoscopic hemostasis was needed in 3.22% of cases;the in-hospital mortality rate was 8.09%, and the bleeding-episode-related mortality rate was 2.97%. Although our predictive models for rebleeding and death had a low sensitivity, the specificity was very high, suggesting a better discriminative capacity for identifying patients with better outcomes. Our results showed that the Rockall score was associated with both rebleeding and death;comorbidities such as respiratory conditions, liver cirrhosis and sepsis increased significantly the risk of in-hospital mortality (OR of 3.29, 2.91 and 8.03). CONCLUSION Our study revealed that the Rockall score, need for endoscopic therapy, necessity of transfusion and sepsis were risk factors for rebleeding. Moreover, an increased Rockall score and the presence of comorbidities were predictive factors for inhospital mortality.Daniela Cornelia Lazar Sorin Ursoniu Adrian Goldis 2019World Journal of Clinical Cases2019,7,18:2
8APPROXIMATION BY COMPLEX SZSZ-DURRMEYER OPERATORS IN COMPACT DISKS显示文摘In the present paper, we deal with the complex Szsz-Durrmeyer operators and study Voronovskaja type results with quantitative estimates for these operators attached to analytic functions of exponential growth on compact disks. Also, the exact order of approximation is found.Sorin G.GAL Vijay GUPTA 2014Acta Mathematica Scientia2014,34,4:2
9Eltrombopag Increases Platelet Numbers in Thrombocytopenic Patients With HCV Infection and Cirrhosis, Allowing for Effective Antiviral Therapy显示文摘Nezam H. Afdhal Geoffrey M. Dusheiko Edoardo G. Giannini Pei–Jer Chen Kwang–Hyub Han Aftab Mohsin Maribel Rodriguez–Torres Sorin Rugina Igor Bakulin Eric Lawitz Mitchell L. Shiffman Ghias–Un–Nabi Tayyab Fred Poordad Yasser Mostafa Kamel Andres Brainsky Ja 2014Gastroenterology2014,,2:2
10Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer 2005World Journal of Gastroenterology2005,11,44:2
11High-resolution impedance mapping using electrically activated quantitative phase imaging显示文摘Retrieving electrical impedance maps at the nanoscale rapidly via nondestructive inspection with a high signal-to-noise ratio is an unmet need,likely to impact various applications from biomedicine to energy conversion.In this study,we develop a multimodal functional imaging instrument that is characterized by the dual capability of impedance mapping and phase quantitation,high spatial resolution,and low temporal noise.To achieve this,we advance a quantitative phase imaging system,referred to as epi-magnified image spatial spectrum microscopy combined with electrical actuation,to provide complementary maps of the optical path and electrical impedance.We demonstrate our system with high-resolution maps of optical path differences and electrical impedance variations that can distinguish nanosized,semi-transparent,structured coatings involving two materials with relatively similar electrical properties.We map heterogeneous interfaces corresponding to an indium tin oxide layer exposed by holes with diameters as small as~550 nm in a titanium(dioxide)over-layer deposited on a glass support.We show that electrical modulation during the phase imaging of a macro-electrode is decisive for retrieving electrical impedance distributions with submicron spatial resolution-and beyond the limitations of electrode-based technologies(surface or scanning technologies).The findings,which are substantiated by a theoretical model that fits the experimental data very well enable achieving electro-optical maps with high spatial and temporal resolutions.The virtues and limitations of the novel optoelectrochemical method that provides grounds for a wider range of electrically modulated optical methods for measuring the electric field locally are critically discussed.Cristina Polonschii Mihaela Gheorghiu Sorin David Szilveszter Gáspár Sorin Melinte Hassaan Majeed Mikhail E.Kandel Gabriel Popescu Eugen Gheorghiu 2021Light(Science & Applications)2021,10,2:2
12基于多源遥感的建筑区绿化垂直分布特征与空间配置分析--以匈牙利塞克什白堡市为例显示文摘为定量描述城市绿化垂直分布特征及其与建筑空间的数量配置关系,以匈牙利塞克什白堡市为例,基于多源遥感数据提取城市绿地和建筑物三维信息,采取垂直空间高度抽样方法,量化不同高度层上绿色空间和建筑空间的分布数量,并依据二者配置的数量关系,将高度空间划分为'相对匮乏层'和'相对饱和层',对比分析了不同功能区的垂直空间配置特征,及其与建筑群结构的相关性。研究结果表明:(1)住宅区和商业区的绿色空间垂直配置结构相似,但住宅区在配置数量上占优;(2)因配置数量不足、垂直配置结构单一等因素,导致商业区三层及以下建筑位置在绿化配置数量上处于较低水平;住宅区因高空绿化配置数量远少于高层建筑数量,存在'高空绿色匮乏'现象;(3)高密度的低建筑群是造成商业区'低空绿色匮乏'的主要建筑结构来源;而忽视高建筑物低密度区的'高空绿化'则是造成住宅区绿色空间匮乏的首要原因。孟庆岩 孙云晓 张佳晖 陈旭 孙震辉 Tamas Jansco Sorin Herban 2018遥感技术与应用2018,33,2:2
13Design of Flexible and Self-Standing Electrodes for Li-lon Batteries显示文摘灵活便携式的电子设备在最后十年期间吸引了增加的注意。如此的设备的精力消费曾经正在增加并且表现电源来源,是而且灵活,要发展无缝地集成到如此的体系结构的需要。当锂离子电池看起来是最好的答案满足电源和精力要求时,他们的结构、机械的考虑仍然需要被探讨。这里,我们认识到碳 nanotubes (CNT ) 的电气化学的表演上的影响基于并且学习,没有收集者、没有文件夹的电流, Li 离子电池电极。多围的碳 nanotubes 是行动一机械并且电子传导性的支架启用结构的灵活性和好电气化学的表演。与如此的电极做的灵活 Li 离子房间证明当通过简单生产被认识到时,答应表演来临。Jean-Pierre Bourgeois Alexandru Vlad Sorin Melinte Jean-Frangois Gohy 2017Chinese Journal of Chemistry2017,35,1:2
14Polyp detection rates using magnification with narrow band imaging and white light显示文摘AIM: To compare the yield of adenomas between narrow band imaging and white light when using high definition/magnification. METHODS: This prospective, non-randomized comparative study was performed at the endoscopy unit of veteran affairs medical center in Phoenix, Arizona. Consecutive patients undergoing first average risk colorectal cancer screening colonoscopy were selected. Two experienced gastroenterologists performed all the procedures that were blinded to each other's findings. Demographic details were recorded. Data are presented as mean ± SEM. Proportional data were compared using the χ2 test and means were compared using the Student's t test. Tandem colonoscopy was performed in a sequential and segmental fashion using one of 3 strategies: white light followed by narrow band imaging [Group A: white light(WL) → narrow band imaging(NBI)]; narrow band imaging followed by white light(Group B: NBI → WL) and, white light followed by white light(Group C: WL → WL). Detection rate of missed polyps and adenomas were evaluated in all three groups. RESULTS: Three hundred patients were studied(100 in each Group). Although the total time for the colonoscopy was similar in the 3 groups(23.8 ± 0.7, 22.2 ± 0.5 and 24.1 ± 0.7 min for Groups A, B and C, respectively), it reached statistical significance between Groups B and C(P < 0.05). The cecal intubation time in Groups B and C was longer than for Group A(6.5 ± 0.4 min and 6.5 ± 0.4 min vs 4.9 ± 0.3 min; P < 0.05). The withdrawal time for Groups A and C was longer than Group B(18.9 ± 0.7 min and 17.6 ± 0.6min vs 15.7 ± 0.4 min; P < 0.05). Overall miss rate for polyps and adenomas detected in three groups during the second look was 18% and 17%, respectively(P = NS). Detection rate for polyps and adenomas after first look with white light was similar irrespective of the light used during the second look(WL → WL: 13.7% for polyps, 12.6% for adenomas; WL → NBI: 14.2% for polyps, 11.3% for adenomas). Miss rate of polyps and adenomas however was significantly higher when NBI was used first(29.3% and 30.3%, respectively; P < 0.05). Most missed adenomas were ≤ 5 mm in size. There was only one advanced neoplasia(defined by size only) missed during the first look. CONCLUSION: Our data suggest that the tandem nature of the procedure rather than the optical techniques was associated with the detection of additional polyps' and adenomas.Nooman Gilani Sally Stipho James D Panetta Sorin Petre Michele A Young Francisco C Ramirez 2015World Journal of Gastrointestinal Endoscopy2015,7,5:2
15Acute Radiation Effects on Cardiac Function Detected by Strain Rate Imaging in Breast Cancer Patients显示文摘Katrien Erven Ruxandra Jurcut Caroline Weltens Sorin Giusca Joris Ector Hans Wildiers Walter Van den Bogaert Jens-Uwe Voigt 2011International Journal of Radiation Oncology, Biology, Physics2011,,5:2
16Seismic fault preserving diffusion 显示文摘OLIVIER L SORIN P CHRISTIAN G 2007Journal of Applied Geo- physies2007,61,2:1
17The activity of γδ T cells against paediatric liver tumour cells and spheroids in cell culture显示文摘Alexander Hoh Alexander Dewerth Fabian Vogt Julia Wenz Patrick A. Baeuerle Steven W. Warmann Joerg Fuchs Sorin Armeanu‐Ebinger 2012Liver Int2012,,1:1
18Laparoscopic surgery in treating hepatic cysts显示文摘 Sorin V Shimonov M 2000Harefuah2000,138,8:1
19Optimization of hydrophilie matrix tablets using a D-optimal design显示文摘ADRIAN B SORIN EL 1997Int J Pharm1997,153,2:1
20Magnesium alloys laser ( Nd : YAG) cladding and alloying with side injection of aluminium powder 显示文摘Sorin Ignat Pierre Sallamand 2004Applied Surface Science2004,225,:1
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