|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current concepts in the management of bisphosphonate associated atypical femoral fractures显示文摘Bisphosphonates are a class of drugs used as the mainstay of treatment for osteoporosis.Bisphosphonates function by binding to hydroxyapatite,and subsequently targeting osteoclasts by altering their ability to resorb and remodel bone.Whilst aiming to reduce the risk of fragility fractures,bisphosphonates have been associated with atypical insufficiency fractures,specifically in the femur.Atypical femoral fractures occur distal to the lesser trochanter,until the supracondylar flare.There are a number of the differing clinical and radiological features between atypical femoral fractures and osteoporotic femoral fractures,indicating that there is a distinct difference in the respective underlying pathophysiology.At the point of presentation of an atypical femoral fracture,bisphosphonate should be discontinued.This is due to the proposed inhibition of osteoclasts and apoptosis,resulting in impaired callus healing.Conservative management consists primarily of cessation of bisphosphonate therapy and partial weightbearing activity.Nutritional deficiencies should be investigated and appro-priately corrected,most notably dietary calcium and vitamin D.Currently there is no established treatment guidelines for either complete or incomplete fractures.There is agreement in the literature that nonoperative management of bisphosphonate-associated femoral fractures conveys poor outcomes.Currently,the favoured methods of surgical fixation are cephalomedullary nailing and plate fixation.Newer techniques advocate the use of both modalities as it gives the plate advantage of best reducing the fracture and compressing the lateral cortex,with the support of the intramedullary nail to stabilise an atypical fracture with increased ability to load-share,and a reduced bending moment across the fracture site.The evidence suggests that cephalomedullary nailing of the fracture has lower revision rates.However,it is important to appreciate that the anatomical location and patient factors may not always allow for this.Although causation between bisphosphonates and atypical fractures is yet to be demonstrated,there is a growing evidence base to suggest a higher incidence to atypical femoral fractures in patients who take bisphosphonates.As we encounter a growing comorbid elderly population,the prevalence of this fracture-type will likely increase.Therefore,it is imperative clinicians continue to be attentive of atypical femoral fractures and treat them effectively. | Branavan Rudran Jonathan Super Rajan Jandoo Victor Babu Soosai Nathan Edward Ibrahim Anatole Vilhelm Wiik | 2021 | World Journal of Orthopedics2021，12，9： | 2 |
| 2 | Mullerian adenosarcoma of uterine cervix : report of three cases and review of literature 显示文摘 | M Manoharan MA Azmi G Soosay | 2007 | Gynecol 0ncol2007，105，1： | 1 |
| 3 | Exploration and exploitation: The interplay between knowledge and continuous innovation显示文摘 | Soosay C Hyland P | 2008 | International Journal of Technology Management2008，42，12： | 1 |
| 4 | Innovation in logistic services and the new business model 显示文摘 | Chapman R L Soosay C Kandampully J | 2003 | International Journal of Physical Distribution & Logistics Management2003，33，7： | 1 |
| 5 | An Empirical Study of Individual Competencies in Distribution Centres to Enable Continuous Innovation显示文摘 | Soosay C A | 2005 | Creativity and Innovation Management2005，14，3： | 1 |
| 6 | Supply chain collaboration: Capabilities for continuous innovation 显示文摘 | Soosay C A Hyland P W Ferrer M | 2008 | Supply Chain Management2008，13，2： | 1 |
| 7 | Inno- vation in logistics services and the new business model: A conceptual framework 显示文摘 | CHAPMAN R L SOOSAY C KARDAMPULLY J | 2003 | International Journal of Physical Distribution & Logistics Management2003，33，7： | 1 |
| 8 | Causes of sensitization in patients awaiting renal transplantation in Ireland显示文摘 | Soosay A O'Neill D Counihan A | 2003 | Ir Med J2003，96，： | 1 |
| 9 | Innovation in logistic services and the new business model:A conceptual framework显示文摘 | Chapman R L Soosay C Kandampully J | 2003 | International Journal of Physical Distribution & Logistics Management2003，33，7： | 1 |
| 10 | Innovation in logistic services and the new business model: A conceptual framework显示文摘 | Ross L Chapman Claudine Soosay Jay Kandarnpully | 2003 | International Journal of Physical Distribution and Logistics Management2003，33，7： | 1 |
| 11 | Innovation in lo- gistic services and the new business model 显示文摘 | CHAPMAN R L SOOSAY C KANDAMPULLY J | 2003 | International Journal of Physical Distribution &Logistics Management2003，33，7： | 1 |
| 12 | Driving Innovation in Logis- tics:Case Studies in Distribution Centers显示文摘 | Soosay Claudine A Hyl Paul W | 2004 | Creativity & Inno- vation Management2004，13，1： | 1 |
| 13 | Innovation in logistic services and the new business model :A conceptual framework显示文摘 | Ross L Chapman Claudine Soosay Jay Kandampully | 2003 | International Journal of Physical Distribution & Logistics Management2003，33，7： | 1 |
| 14 | Exploration and exploitation the inter- play between knowledge and continuous innovation 显示文摘 | Soosay C Hyland P | 2008 | Inter- national Journal of Technology Management2008，42，12： | 1 |
| 15 | Supply chain collaboration: capabilities for continuous innovation 显示文摘 | Claudine A Soosay Paul W Hyland Mario Ferrer | 2008 | Supply Chain Management: An International Journal2008，13，2： | 1 |
| 16 | Supply chain collaboration: capabilities for continuous innovation 显示文摘 | Soosay C A Hyland P W Ferrer M | 2008 | Supply Chain Managementan International Journal2008，13，2： | 1 |
| 17 | Innovation in logistic services and the new business model 显示文摘 | Chapman R L Soosay C Kandampully J | 2003 | International Journal of Physical Distribution & Logistics Management2003，33，7： | 1 |
| 18 | Effect of Firm Contingencies on Continuous Innovation 显示文摘 | Soosay C A Hyland P W | 2005 | International Journal of Innova- tion and Technology Management2005，2，2： | 1 |
| 19 | An Empirical Examination of Per- formance Measurement for Managing Continuous Innovation in Logistics 显示文摘 | Soosay C A Chapman R L | 2006 | Knowledge and Process Management2006，13，3： | 1 |
| 20 | Supply chain collaboration: capabilities for continuous innovation显示文摘 | SOOSAY C A HYLAND P W FERRER M | 2008 | Sup- ply Chain Management: An International Journal2008，13，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员