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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | NKX6.3 protects against gastric mucosal atrophy by downregulatingβ-amyloid production显示文摘BACKGROUND Atrophic gastritis is characterized by loss of appropriate glands and reduction in gastric secretory function due to chronic inflammatory processes in gastric mucosa. Moreover, atrophic gastritis is considered as a precancerous condition of gastric cancer. However, little is known about the molecular mechanism underlying gastric mucosal atrophy and its contribution to gastric carcinogenesis.Thus, we hypothesized that transcription factor NKX6.3 might be involved in maintaining gastric epithelial homeostasis by regulating amyloid β(Aβ)production.AIM To determine whether NKX6.3 might protect against gastric mucosal atrophy by regulating Aβ production.METHODS We identified NKX6.3 depletion induced cell death by cell count and Western blot assay. Production and mechanism of Aβ oligomer were analyzed by enzymelinked immunosorbent assay, Western blot, immunoprecipitation, real-timequantitative polymerase chain reaction and immunofluorescence analysis. We further validated the correlation between expression of NKX6.3, Helicobacter pylori CagA, Aβ oligomer, apolipoprotein E(ApoE), and β-secretase 1(Bace1) in 55 gastric mucosae.RESULTS NKX6.3 depletion increased both adherent and floating cell populations in HFE-145 cells. Expression levels of cleaved caspase-3,-9, and poly ADP ribose polymerase were elevated in floating HFE-145^(shNKX6.3) cells. NKX6.3 depletion produced Aβ peptide oligomers, and increased expression of ApoE, amyloid precursor protein, Aβ, Bace1, low-density lipoprotein receptor, nicastrin, high mobility group box1, and receptor for advanced glycosylation end product proteins. In immunoprecipitation assay, γ-secretase complex was stably formed only in HFE-145^(shNKX6.3) cells. In gastric mucosae with atrophy, expression of Aβpeptide oligomer, ApoE, and Bace1 was detected and inversely correlated with NKX6.3 expression. Treatment with recombinant Aβ 1-42 produced Aβoligomeric forms and decreased cell viability in HFE-145^(shNKX6.3) cells. Additionally,NKX6.3 depletion increased expression of inflammatory cytokines and cyclooxygenase-2.CONCLUSION NKX6.3 inhibits gastric mucosal atrophy by regulating Aβ accumulation and inflammatory reaction in gastric epithelial cells. | Jung Hwan Yoon Yeon Soo Lee Olga Kim Hassan Ashktorab Duane T Smoot Suk Woo Nam Won Sang Park | 2019 | World Journal of Gastroenterology2019，25，3： | 6 |
| 3 | The journal impact factor: Too much of an impact 显示文摘 | Ha T Tan S Soo K | 2006 | Ann Acad Med Singapore2006，35，12： | 1 |
| 4 | Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with epidermal growth factor receptor expression显示文摘 | Soo R Putti T Tao Q | 2005 | Arch Otolaryngol Head Neck Surg2005，131，2： | 1 |
| 5 | External knowledge acquisition, creativity and learning in or- ganisational problem solving 显示文摘 | Soo C W Devinney T M Midgley D F | 2007 | International Jour- nal of Technology Management2007，38，12： | 1 |
| 6 | A simple gold nanoparticle probes assay for identification of Mycobacterium tuberculosis and Mycobacterium tuberculosis complex from clinical specimens显示文摘 | Soo P C Horng Y T Chang K C | 2009 | Mol Cell Probes2009，23，5： | 1 |
| 7 | CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney显示文摘 | Soos T J Sims T N Barisoni L Lin K Littman D R Dustin M L | 2006 | Kidney lnt2006，70，： | 1 |
| 8 | Mechanical properties of talc-and (calcium carbonate )-filled poly (vinyl chloride) hybrid composites 显示文摘 | Soo T B Azman H Aznizam A B | 2012 | J Vinyl Addit Teehn2012，18，2： | 1 |
| 9 | Evapotranspiration and crop coefficient of common reed at the surroundings of Lake Balaton, Hungary显示文摘 | Anda A da Silva J A T Soos G | 2014 | Aquatic Botany2014，116，： | 1 |
| 10 | New uniplanar subnanosecond monocycle pulse generator and transfor-mer for time-domain microwave applications显示文摘 | Jeong Soo Lee Nguyen C Scullion T | 2001 | IEEE Transactions on MTT2001，49，6： | 1 |
| 11 | Biotechnol Bioeng 显示文摘 | Lee K G Park T J Soo S Y | 2010 | 107(4): 747-7512010，107，4： | 1 |
| 12 | Reversible cerebral vasocon-striction syndrome with posterior leucoencephalopathy after o- ral contraceptive pills显示文摘 | Soo Y Singhal A Leung T | 2010 | Cephalalgia2010，30，1： | 1 |
| 13 | The effect of bone morphogenetic protein-2 on rat in- tervertebral disc cells in vitro显示文摘 | Tim Yoon S Su Kim K Li J Soo Park J Akamaru T Elmer W A | 2003 | Spine(Phila Pa 1976)2003，28，： | 1 |
| 14 | Protein kinase c theta inhibits insulin signaling by phosphorylating irsl at ser(ll01) 显示文摘 | LI Y SOOS T J LI X H | 2004 | J Biol Chem2004，279，45： | 1 |
| 15 | Diagnostic value of 64-slice multi-detector row cardiac CTA in symptomatic patients 显示文摘 | Muhlenbruch G Seyfarth T Soo CS | 2007 | Eur Radiol2007，17，： | 1 |
| 16 | Assessment of skin types, skin eolours and cutaneous responses to ultraviolet radiation in an Asian population显示文摘 | Wee L Choug T K Koh Soo Quee D | 1997 | Photodermatology photoimmunology & photomedicine1997，13，56： | 1 |
| 17 | New uniplanar subnanosecond monocycle pulse generator and transformer for time-domain microwave applications显示文摘 | Lee Jeong Soo Nguyen C Scullion T | 2001 | IEEE Transactions on MTT2001，49，6： | 1 |
| 18 | New uniplanar subnanosecond monocycle pulse generator and transformer for time-domain microwave applications显示文摘 | Jeong Soo Lee Nguyen C Scullion T | 2001 | IEEE Transactions on Microwave Theory and Techniques2001，49，6： | 1 |
| 19 | Extending existing dependency theory to temporal databasesi显示文摘 | JENSEN C S SNODGRASS R T SOO M D | 1996 | IEEE Transactions on Knowledge and Data Engineering1996，8，4： | 1 |
| 20 | Endogenous prostaglandin D2 synthesis reduces an in- crease in plasminogen activator inhibitor-I following interleukin stimulation in bovine endothelial cells 显示文摘 | Negoro H Soo Shin W Hakamada-Taguchi R Eguchi N Urade Y Goto A Toyo-Oka T Fujita T Omata M Uehara Y | 2002 | J Hypertens2002，20，： | 1 |
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