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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | External knowledge acquisition, creativity and learning in or- ganisational problem solving 显示文摘 | Soo C W Devinney T M Midgley D F | 2007 | International Jour- nal of Technology Management2007，38，12： | 1 |
| 3 | CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney显示文摘 | Soos T J Sims T N Barisoni L Lin K Littman D R Dustin M L | 2006 | Kidney lnt2006，70，： | 1 |
| 4 | Neoadjuvant and adjuvant therapy for surgical resection of hepatocellular carcinoma显示文摘 | Samuel M Chow PK Chan Shih-Yen E Machin D Soo KC | | 0，，01： | 1 |
| 5 | Extending existing dependency theory to temporal databasesi显示文摘 | JENSEN C S SNODGRASS R T SOO M D | 1996 | IEEE Transactions on Knowledge and Data Engineering1996，8，4： | 1 |
| 6 | Extending existing dependency theory to temporal databases 显示文摘 | C S Jensen R T Snodgrass M D Soo | 1996 | IEEE Trans on Knowledge and Data Engineering1996，8，4： | 1 |
| 7 | External knowledge acquisition, creativity and learning in orga- nizational problem solving显示文摘 | Soo C W Devinney T M Midgley D F | 2007 | International Journal of Technology Management2007，38，12： | 1 |
| 8 | Detection of epidermal growth fac- tor receptor variations by partially denaturing HPLC 显示文摘 | Chin T M Anuar D Soo R | 2007 | Clin Chem2007，53，1： | 1 |
| 9 | Is there a global definition of academic quality? A cross-national analysis of university ranking systems显示文摘 | Dill D Soo M | 2004 | Public Policy for Academic Quality University of North Carolina at Chapel Hill2004，2004，： | 1 |
| 10 | Extending existing dependency theory to temporal databases 显示文摘 | Jensen C S Snodgrass R T Soo M D | 1996 | IEEE Transactions on Knowledge and Data Engineering1996，8，4： | 1 |
| 11 | The Longitudinal Accuracy of Fit of Titanium Implant Superstructures Superplastically Formed on Investment Models 显示文摘 | Soo S Garriga-Majo D Palmer R M | 2004 | Dental Materials2004，20，： | 1 |
| 12 | Development of the ac-tive balancing device for high - speedspindle system usinginfluence coefficients 显示文摘 | Jong D M Bong S K Soo H L | 2006 | International Journal of Ma-chine Tools & Manufacture2006，，46： | 1 |
| 13 | New european gyroscopes for space use显示文摘 | SOO D N VUILLEUMIER P WEINBERGER M | 1998 | Preparing to the future1998，8，1： | 1 |
| 14 | Extending existing dependency theory to temporal databases显示文摘 | C S Jensen R T Snodgrass M D Soo | 1996 | IEEE Trans Knowledge and Data Engineering1996，8，4： | 1 |
| 15 | External Knowledge Acqui- sition, Creativity and laming in Organizational Problem Solving 显示文摘 | Soo C W Devinney T M Midgley D F | 2007 | International Journal of Technology Mmaagent2007，38，1： | 1 |
| 16 | Microbial community composition in soils of Northern Victoria Land,Antarctica 显示文摘 | Niederberger T D McDonald I R Hacker A L Soo R M Barrett J E Wall D H Cary S C | 2008 | Environmental Microbiology2008，10，7： | 1 |
| 17 | External Knowledge Acquisition, Creativity and Learning in Organizational Problem Solving 显示文摘 | SOO C W DEVINNEY T M MIDGLEY D F | 2007 | International Journal of Technology Management2007，38，12： | 1 |
| 18 | External knowledge acquisition, creativity and learning in of or- ganizational problem solving显示文摘 | Soo C W Devinney T M Midgley D F | 2007 | International Journal of Technology Management2007，38，2： | 1 |
| 19 | Preferential oxidation of CO under excess H2 conditions over Ru catalysts显示文摘 | Soo Yin Chin Alexeev O S Amiridis M D | 2005 | Applied Catalysts A: General2005，286，： | 1 |
| 20 | Reaction of Sara of the Korean Children Free from Hib Invasive Diseases against Hinfluenzae type b capsular Polysaccharide Antigen显示文摘 | Kyung H Kim M D Dong Soo Kim M D | 1994 | J Korean Med Sci1994，9，1： | 1 |
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