|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 3 | The proteasome inhibitor MG132 protects against acute pancreatitis显示文摘 | Letoha T Somlai C Takacs T | 2005 | Free Radio Biol Med2005，39，9： | 1 |
| 4 | Association of microvessel density with infiltrating cells in human cutaneous malignant melanoma显示文摘 | Kiss J Timar J Somlai B | 2007 | Pathol Oncol Res2007，13，1： | 1 |
| 5 | Loss of vascular adhesion protein-1 expression inintra-tumoral microvessels of human skin melanoma显示文摘 | Forster-Horvath C Dome B Paku S Laddnyi A Somlai B’Jal-kanen S | 2004 | Mela-noma i2es2004，14，2： | 1 |
| 6 | Radiologieal aspects of the usa- bility of red mud as building material additive 显示文摘 | Somlai J Jobbagy V Kovacs J | 2008 | Journal of hazard- ous materials2008，150，： | 1 |
| 7 | Radiological investigation of the effects of red mud disaster显示文摘 | Kovacs T Sas Z Somlai J | 2012 | Radiat Prot Dosimetry2012，152，13： | 1 |
| 8 | Vascularization of cutaneous melanoma involves vessel cooption and has clinical significance显示文摘 | Dome B Paku S Somlai B | 2002 | The Journal of Pathology2002，197，3： | 1 |
| 9 | T-cell activation marker expression on tumor-infiltrating lymphocytes as prognostic factor in cutaneous malignant melanoma 显示文摘 | Ladanyi A Somlai B Gilde K | 2004 | Clin Cancer Res2004，10，2： | 1 |
| 10 | The proteasome inhibitor MG132 protects against acute pancreatitis显示文摘 | Letoha T Somlai C Takács T | 2005 | Free Radical Biol Med2005，39，9： | 1 |
| 11 | The proteasome inhibitor MG- 132 protects against acute pancreatitis 显示文摘 | Letoha T Somlai C Takacs T | 2005 | Free Radio Biol Med2005，39，9： | 1 |
| 12 | Predictors of HIV Sexual Risk Behaviors in a Community Sample of Injection Drug-Using Men and Women显示文摘 | Somlai A M Kelly J A McAuliffe T L | 2003 | AIDS and Behavior2003，7，： | 1 |
| 13 | Hydrodynamics of the Effectiveness of the AP-CITROX Decontamination Technology 显示文摘 | Varga K N~meth Z Somlai J | 2002 | Journal of Radioanalytical and Nuclear Chemistry2002，254，3： | 1 |
| 14 | The proteasome inhibitor MG-132 protects against acute pancreatitis 显示文摘 | Letoha T Somlai C Takacs T | 2005 | Free Radical Biol Med2005，39，9： | 1 |
| 15 | Molecular identification, localization and function of platelet-type 12-lipoxygenase in human melanona progression, under experimental and clinical conditions显示文摘 | Raso E Dome B Somlai B | 2004 | Melanoma Res2004，14，4： | 1 |
| 16 | Radiological aspects of the usability of red mud as building material additive 显示文摘 | Janos Somlai | 2008 | Journal of Hazardous Materials2008，150，3： | 1 |
| 17 | Effect of liquid ammonia on the fine structure of linen fabrics显示文摘 | Barbara Doruyi Emilia Csiszar Csiszar Somlai | 2006 | Textile Res J2006，，1： | 1 |
| 18 | Molecular identification, localization and function of platelet type 12-lipoxygenase in human melanona progression, under experimental and clinical conditions显示文摘 | Raso E Dome B Somlai B | 2004 | Melanoma Res2004，14，4： | 1 |
| 19 | Radiological aspects of the usability of red mud as building material additive显示文摘 | Somlai J Jobbágy V Kovács J Tarján S Kovács T | | 0，，： | 1 |
| 20 | Predictors of continued high-risk sexual behavior in a community sample of persons living with HIV/AIDS显示文摘 | HECKMAN TG KELLY JA SOMLAI AM | 1998 | AIDS Behav1998，2，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员