| 3 | Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis显示文摘Dear Editor,Accumulating evidence suggests that dysregulated lysosomal membrane proteins,including vacuolar ATPase(v-ATPase)and the mammalian target of rapamycin(mTOR),are involved in tumorigenesis[1].Therefore,lysosomal proteins were proposed as potential therapeutic targets in cancer[1].As one of the lysosome-related signaling pathways,mTOR signaling regulates cell proliferation,survival,motility,and metabolism[2].SincemTOR signaling activation promotes tumorigenesis,mTOR inhibitors(mTORi),AZD8055[3],MLN0128[4],and Rapalink-1(the latest third-generation mTORi)[4],have been applied to several cancers.However,the limitations of mTORi include drug resistance and the lack of biomarkers. | Shengzhe Zhang Sung Ho Lee Litong Nie Yuanjian Huang Gengyi Zou Youn-Sang Jung Sohee Jun Jie Zhang Esther MLien Junjie Chen Jae-Il Park | 2023 | Cancer Communications2023，43，1： | 0 |
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