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| 1 | Irritable bowel syndrome:A clinical review显示文摘Irritable bowel syndrome(IBS)remains a clinical challenge in the 21st century.It’s the most commonly diagnosed gastrointestinal condition and also the most common reason for referral to gastroenterology clinics.Its can affect up to one in five people at some point in their lives,and has a significantly impact of life quality and health care utilization.The prevalence varies according to country and criteria used to define IBS.Various mechanisms and theories have been proposed about its etiology,but the biopsychosocial model is the most currently accepted for IBS.The complex of symptoms would be the result of the interaction between psychological,behavioral,psychosocial and environmental factors.The diagnosis of IBS is not confirmed by a specific test or structural abnormality.It is made using criteria based on clinical symptoms such as Rome criteria,unless the symptoms are thought to be atypical.Today the Rome CriteriaⅢis the current goldstandard for the diagnoses of IBS.Secure positive evidence of IBS by means of specific disease marker is currently not possible and cannot be currently recommended for routine diagnosis.There is still no clinical evidence to recommend the use of biomarkers in blood to diagnose IBS.However,a number of different changes in IBS patients were demonstrated in recent years,some of which can be used in the future as a diagnostic support.IBS has no definitive treatment but could be controlled by non-pharmacologic management eliminating of some exacerbating factors such certain drugs,stressor conditions and changes in dietary habits.The traditional pharmacologic management of IBS has been symptom based and several drugs have been used.However,the cornerstone of its therapy is a solid patient physician relationship.This review will provide a summary of pathophysiology,diagnostic criteria and current and emerging therapies for IBS. | Rosa LS Soares | 2014 | World Journal of Gastroenterology2014，20，34： | 16 |
| 2 | Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary report显示文摘 | Cohen LS Soares CN Poitras JR | 2003 | Am J Psychiatry2003，160，： | 1 |
| 3 | Strategy for apexifieation of wide-open apex associated with extensive periapical lesion in a weakened root显示文摘 | Costa GM Soares SM Marques LS | 2013 | Gen Dent2013，61，3： | 1 |
| 4 | Risk for new onset of depression during the menopausal transition-the Harvard study of moods and cycles显示文摘 | Cohen LS Soares CN Vitonis AF | 2006 | Archives of General Psychiatry2006，63，4： | 1 |
| 5 | Short-term use of estradiol for depression inperimenopausal and postmenopausal womem a preliminary report 显示文摘 | Cohen LS Soares CN Poitras JR | 2003 | American Journal of Psychiatry2003，160，8： | 1 |
| 6 | Risk for new onset of depression during the menopausal transition :the Harvard study of moods and cycles 显示文摘 | Cohen LS Soares CN Vitonis AF | 2006 | Arch Gen Psychiatry2006，63，4： | 1 |
| 7 | Glomerular filtration rate estimation:performance of serum cystatin C-based prediction equations显示文摘 | Weinert LS Camargo EG Soares AA | 2011 | Clin Chem Lab Med2011，49，11： | 1 |
| 8 | Glomerular filtration rate estimation:performance of serum cystatin C-based prediction equations显示文摘 | Weinert LS Camargo EG Soares AA | | 0，，11： | 1 |
| 9 | Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species(Asteraceae) correlated with the pres- ence of acetylene and flavonoid compounds显示文摘 | Brand/io MG Krettli AU Soares LS | 1997 | J Ethno- pharmacol1997，57，2： | 1 |
| 10 | Photodynamic effect of light-emitting diode light on cell growth inhibition induced by methylene blue显示文摘 | Peloi LS Soares RR Biondo CE | 2008 | Boisci2008，33，2： | 1 |
| 11 | Risk for new onset of depression during the menopausal transition:the Harvard study of moods and cycles显示文摘 | Cohen LS Soares CN Vitonis AF | 2006 | Arch Gen Psychiatry2006，63，4： | 1 |
| 12 | Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary report显示文摘 | Cohen LS Soares CN Poitras JR | 2003 | Am J Psychiatry2003，160，： | 1 |
| 13 | Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles显示文摘 | Cohen LS Soares CN Vitonis AF | 2006 | Arch Gen Psychiatry2006，63，4： | 1 |
| 14 | Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles 显示文摘 | Cohen LS Soares CN Vitonis AF | 2006 | Arch Gen Psychiatry2006，63，4： | 1 |
| 15 | Glomerular filtration rate estimation:performance of serum cystatin C-based prediction equations显示文摘 | Weinert LS Camargo EG Soares AA | | 0，，11： | 1 |
| 16 | Vitonis AF,et al,Risk for new onset of depression during the menopausal transition:the Harvard study of moods and cycles显示文摘 | Soares ON | 2006 | Arch Gen Psychiatry2006，63，4： | 1 |
| 17 | Risk for new onset of depression during the menopausal transition:the Harvard study of moods and cycles显示文摘 | Cohen LS Soares CN Vitonis AF | 2006 | Arch Gen Psychiatry2006，63，4： | 1 |
| 18 | Strategy for apexifi cation of wide-open apex associated with extensive periapical lesion in a weakened root显示文摘 | Costa GM Soares SM Marques LS | 2013 | Gen Dent2013，，： | 1 |
| 19 | Glomerular filtration rate esti-mation:performance of serum cystatin C-based prediction equa-tions 显示文摘 | Weinert LS Camargo EG Soares AA | 2011 | Clin Chem Lab Med2011，49，11： | 1 |
| 20 | Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles显示文摘 | Cohen LS Soares CN Vitonis AF | 2006 | Arch Gen Psychiatry2006，63，4： | 1 |
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