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| 1 | Hepatic encephalopathy: Ever closer to its big bang显示文摘Hepatic encephalopathy(HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy(MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations. The development of MHE is associated with worsen in driving skills, daily activities and the increase of overall mortality. Skeletal muscle has the ability to shift from ammonia producer to ammonia detoxifying organ. Due to its large size, becomes the main ammonia detoxifying organ in case of chronic liver failure and muscular glutaminesynthase becomes important due to the failing liver and brain metabolic activity. Gut is the major glutamine consumer and ammonia producer organ in the body. Hepatocellular dysfunction due to liver disease, results in an impaired clearance of ammonium and in its interorgan trafficking. Intestinal bacteria, can also represent an extra source of ammonia production and in cirrhosis, small intestinal bacterial overgrowth and symbiosis can be observed. In the study of HE, to get close to MHE is to get closer to its big bang; and from here, to travel less transited roads such as skeletal muscle and intestine, is to go even closer. The aim of this editorial is to expose this road for further and deeper work. | Pablo A Souto Ariel R Marcotegui Lisandro Orbea Juan Skerl Juan Carlos Perazzo | 2016 | World Journal of Gastroenterology2016，22，42： | 6 |
| 2 | Effects of carvedilol on adrenergic receptor pharmacology in human ventricular myocardium and lymphocytes显示文摘 | Prof. Dr. M. R. Bristow P. Larrabee B. Müller-Beckmann W. Minobe R. Roden L. Skerl J. Klein D. Handwerger J. D. Port | 1992 | The Clinical Investigator1992，，2： | 1 |
| 3 | Anisotropy of Solid Breast Lesions in 2D Shear Wave Elastography is an Indicator of Malignancy显示文摘 | Skerl K Vinnicombe S Thomson K | 2016 | Acad Radiol2016，23，1： | 1 |
| 4 | Residues of pesticides in honeybee (Apis mellifera carnica) bee bread and in pollen loads from treated apple orchards 显示文摘 | SMODIS SKERL M I VELIKONJA BOLTA S BASA CESNIK H | 2009 | Bulletin of Environmental Contamination and Toxicology2009，83，3： | 1 |
| 5 | Influence of region of interest size and ultrasound lesion size on the performance of 2D shear wave elastography(SWE)in solid breast masses显示文摘 | Skerl K Vinnicombe S Giannotti E | 2015 | Clin Radiol2015，70，12： | 1 |
| 6 | A protocol for evaluation of similarity measures for rigid registration 显示文摘 | Skerl D Likar B Pernug F | 2006 | IEEE Transactions on Medical Imaging2006，25，6： | 1 |
| 7 | AMO f ramework for tea m i n novat ion:ef f icac yb e l i e f s,p r o a c t i v e p e r s o n a l i t i e s,s u p p o r t i v esuper v ision显示文摘 | K r ape z J Cer ne M Skerl avaj M et a l | | Academy of Management A nnua lMeet i n g P roceed i n g s0，2014，15： | 1 |
| 8 | Biosynthesis of palmatine in Fagaracoco显示文摘 | Skerl AR Gros EG | 1971 | Phytochemistry1971，10，11： | 1 |
| 9 | Prevalence of and risk factors for hospital-acquired infections in Slovenia-results of the first national survey, 2001 显示文摘 | Klavs I Bufon Lucnik T Skerl M | 2003 | Journal of Hospital Infection2003，54，2： | 1 |
| 10 | Changes produced in oils during vacuum and traditional frying of potato chips显示文摘 | Crosa M J Skerl V Cadenazzi M | 2014 | Food Chemistry2014，146，2： | 1 |
| 11 | Prevalance of and risk factors for hospital-acquired infections in slovenia-results of the first national survey, 2001显示文摘 | Klavs I Bufon LT Skerl M | 2003 | JHosp lnfect2003，54，2： | 1 |
| 12 | Prevalance of and risk factors for hospital-acquired infections in slovenia-results of the first national survey, 2001显示文摘 | KLAVS I BUFON LT SKERL M | 2003 | J Hosp Infect2003，54，2： | 1 |
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