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| 1 | Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy显示文摘我们与优先的主要雄激素剥夺治疗(ADT ) 在变形前列腺癌症在前进木头(PSAVAP ) 以后调查了前列腺特定的抗原天底(TTPN ) 和前列腺特定的抗原速度的对数的时间的协会。从 2000 ~ 2009 与主要 ADT 对待的所有变形前列腺癌症病人被考察。开发了疾病前进的病人在随后的分析被包括。病人们根据他们的 TTPN 被分成三个组:< 的 TTPN; 3 个月, 3-17 月,和 > 17 个月。我们用 Mann-Whitney U-test 和 Kruskal-Wallis 测试比较了在不同 TTPN 组之间的木头(PSAVAP ) 。木头(PSAVAP ) 上的进一步多重的线性回归分析被执行为使因素惊讶的另外的潜力调整。在与主要 ADT 被对待的 419 个病人之中, 306 个病人与 28 个月的中部的后续开发了疾病前进。更长的 TTPN 与更低的木头(PSAVAP ) 被联系(P = 0.008 ) 在所有亚群分析以内(< 的 TTPN; 3 对 3-17 月, P = 0.020;3-17 对 > 的 TTPN; 17 个月, P = 0.009;并且 < 的 TTPN; 3 对 > 17 个月, P = 0.001 ) 。在多重线性回归分析之上,基线 PSA (回归系数 0.001 , P = 0.045 ), PSA 天底(回归系数 0.002 , P = 0.040 ),并且 TTPN (回归系数 − ; 0.030 , P = 0.001 )是显著地与木头( PSAVAP )被联系的三个因素。在结论,更长的 TTPN 在跟随主要 ADT 的变形前列腺癌症病人与更低的木头(PSAVAP ) 被联系。在 3 个月和 17 个月的 TTPN cut-offs 看起来在预言木头(PSAVAP ) 有预示的意义。TTPN 可以在与疾病前进在病人决定治疗策略用作好预示的指示物。 | Jeremy YC Teoh James HL Tsu Steffi KK Yuen Peter KF Chiu Samson YS Chan Ka-Wing Wong Kwan-Lun Ho Simon SM Hou Chi-Fai Ng Ming-Kwong Yiu | 2017 | Asian Journal of Andrology2017，19，1： | 6 |
| 2 | Familial adenomyosis: a case report 显示文摘 | Arnold LL Ascher SM Simon JA | 1994 | Fertil Steril1994，61，6： | 1 |
| 3 | BY1023/ SL&F96022;biochemistry of a novel ( H -- -- K-I- ) -- ATP ade inhibitor显示文摘 | SIMON WA KEELING DJ LAING SM | 1990 | Bioehem Pharmacol1990，39，： | 1 |
| 4 | Imaging the biogenesis of individual HIV-1 virions in liver cells显示文摘 | Jouvenet N Bieniasz PD Simon SM | 2008 | Nature2008，454，7201： | 1 |
| 5 | Laparoseopic-Assisted Versus Open Abdominoperineal Resection for Low Rectal Cancer: A Prospective Randomized Trial显示文摘 | Simon SM FRCSE d(Gen) Leung KL | 2008 | Ann Surg Oncol2008，15，9： | 1 |
| 6 | Imaging with total inter-nal reflection fluorescence microscopy for the cell biologist显示文摘 | Mattheyses AL Simon SM Rappoport JZ | 2010 | JCell Sci2010，123，21： | 1 |
| 7 | Endoscopic submucosal dissection vs laparoscopic colorectal resection for early colorectal epithelial neoplasia显示文摘AIM: To compare the short term outcome of endoscopic submucosal dissection(ESD) with that of laparoscopic colorectal resection(LC) for the treatment of early colorectal epithelial neoplasms that are not amenable to conventional endoscopic removal. METHODS: This was a retrospective cohort study. The clinical data of all consecutive patients who underwent ESD for endoscopically assessed benign lesions that were larger than 2 cm in diameter from 2009 to 2013 were collected. These patients were compared with a cohort of controls who underwent LC from 2005 to 2013. Lesions that were proven to be malignant by initial endoscopic biopsies were excluded. Mid and lower rectal lesions were not included because total mesorectal excision, which bears a more complicated postoperative course, is not indicated for lesions without histological proof of malignancy. Both ESD and LC were performed by the same surgical unit with a standardized technique. The patients were managed according to a standard protocol, and they were closely monitored for complications after the procedures. All hospital records were reviewed, and the following data were compared between the ESD and LC groups: patient demographics, size and location of the lesions, procedure time, shortterm clinical outcomes and pathology results. RESULTS: From 2005 to 2013, 65 patients who underwent ESD and 55 patients who underwent LC were included in this study. The two groups were similar in terms of sex(P = 0.41) and American Society of Anesthesiologist class(P = 0.58), although patients in the ESD group were slightly older(68.6 ± 9.4 vs 64.6 ± 9.9, P = 0.03). ESD could be accomplished with a shorter procedure time(113 ± 66 min vs 153 ± 43 min, P < 0.01) for lesions of comparable size(3.0 ± 1.2 cm vs 3.4 ± 1.4 cm, P = 0.22) and location(colon/rectum:59/6 vs colon/rectum: 52/3, P = 0.43). ESD appeared to be associated with a lower short-term complication rate, but the difference did not reach statistical significance(10.8% vs 23.6%, P = 0.06). In the LC arm, a total of 22 complications occurred in 13 patients. A total of 7 complications occurred in the ESD arm, including 5 perforations and 2 episodes of bleeding. All perforations were observed during the procedure and were successfully managed by endoscopic clipping without emergency surgical intervention. Patients in the ESD arm had a faster recovery than patients in the LC arm, which included shorter time to resume normal diet(2 d vs 4 d, P = 0.01) and a shorter hospital stay(3 d vs 6 d, P < 0.01). CONCLUSION: ESD showed better short-term clinical outcomes in this study. Further prospective randomized studies will be required to evaluate the efficacy and superiority of colorectal ESD over LC. | Sophie SF Hon Simon SM Ng Tiffany CL Wong Philip WY Chiu Tony WC Mak WW Leung Janet FY Lee | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 1 |
| 8 | Diathesis-stress theorisis in the context of life stress research:Implications for the depressive disorders显示文摘 | Monroe SM Simons AD | 1991 | Psychological bulletin1991，110，3： | 1 |
| 9 | Cell biological mechanismsof multidrug resistance in tumors显示文摘 | Simon SM Schindler M | 1994 | Proc Natl Acad Sci USA1994，91，9： | 1 |
| 10 | The nitric oxide pathway modulates hemangioblast activity of adult hematopoietic stem cells 显示文摘 | Guthrie SM Curtis LM Mames RN Simon GG Grant MB Scott EW | 2005 | Blood2005，105，5： | 1 |
| 11 | Differential proteomic analysis of the endoplasmic reticulum from developing and germinating seeds of castor( Ricinus communis)identifies seed protein precursors as significant components of the endoplas- mic reticulum 显示文摘 | Maltman DJ Gadd SM Simon WJ | 2007 | Proteomics2007，7，： | 1 |
| 12 | Subcellular localization and activity of multidrug resistance proteins 显示文摘 | Rajagopal A Simon SM | 2003 | Mol Biol Cell2003，14，8： | 1 |
| 13 | MR of primary CNS lymphoma in immunologically normal patients显示文摘 | Simon M Roman-Goldstein SM Goldman DL | 1992 | AJNR1992，13，： | 1 |
| 14 | Association of circulating receptor FcβR Ⅲ - positive monocytes in AIDS patients with elevated levels of transforming growth factor - β 显示文摘 | Alle JB Wong HL Guyre PM Simon GL Wahl SM | 1991 | J Clin In- vest1991，87，： | 1 |
| 15 | Receptor-mediated glutamate release from volume sensitive channels in astrocytes显示文摘 | Takano T Kang J Jaiswal JK Simon SM Lin JH Yu Y | | Proc Natl Acad Sci0，102，16： | 1 |
| 16 | A randomized controlled trial of postthoracotomy pulmonary rehabilitation in patients with resectable lung cancer显示文摘 | Stigt JA Uil SM Simons FJ | 2013 | J Thorac Oncol2013，8，2： | 1 |
| 17 | Familial multisystem degenera-tion with parkinsonism associated with the 11778 mitochondrial DNAmutation显示文摘 | Simon DK Pulst SM Sutton JP | 1999 | Neurology1999，53，： | 1 |
| 18 | Increase in erythrocyte disaggregation shear stress in hypertension显示文摘 | Razavian SM Pino MD simon A | 1992 | Hypertension1992，20，： | 1 |
| 19 | Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers显示文摘 | London ED Simon SL Berman SM | 2004 | Arch Gen Psychiatry2004，61，1： | 1 |
| 20 | Xenophagy in Helicobacter pylori ‐ and Epstein–Barr virus‐induced gastric cancer显示文摘 | Lin Zhang Joseph JY Sung Jun Yu Siew C Ng Sunny H Wong Chi H Cho Simon SM Ng Francis KL Chan William KK Wu | 2014 | Pathol2014，，2： | 1 |
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