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| 1 | The selection of volume ratio of two-stage rotary compressor and its effects on air-to-water heat pump with flash tank cycle显示文摘 | Younghwan Ko Sangkyoung Park Simon Jin Byungsoon Kim Ji Hwan Jeong | 2013 | Applied Energy2013，，： | 1 |
| 2 | Alpha-actinin:a direct link between actin and integrins显示文摘 | Pavalko FM Otey CA Simon KO | 1991 | Biochem Soc Trans1991，19，4： | 1 |
| 3 | Study of acute trichinosis in Ghuskas: specificity and sensitivity of enzyme-linked immunosorbent assay for IgM and IgE antibodies to TrichineUa larval antigens in diagnosis显示文摘 | Au AC Ko RC Simon JW | 1983 | Trans R Soc Trop Med Hyg1983，77，3： | 1 |
| 4 | Study of acute trichinosis in Ghurkas:specificity and sensitivity of enzyme-linked immunosor-bent assays for IgM and IgE antibodies toTrichinellalarval anti-gens in diagnosis显示文摘 | Au AC Ko RC Simon JW | 1983 | Trans R Soc Trop Med Hyg1983，77，3： | 1 |
| 5 | Ischemia-induced regional wall motion abnormality is improved after coronary angioplasty: demonstration by dobutamine stress echocardiography 显示文摘 | Akosah KO Porter TR Simon R | 1993 | J Am Coll Cardiol1993，21，3： | 1 |
| 6 | Performance analysis and optimization of switched diversity systems显示文摘 | KO Y C ALOUINI M S SIMON M K | 2000 | IEEE Trans Veh Technol2000，49，： | 1 |
| 7 | Exploratory study of understanding hotel employees’ perception on work–life balance issues显示文摘 | Simon Chak-keung Wong Annie Ko | 2008 | International Journal of Hospitality Management2008，，2： | 1 |
| 8 | Study of acute trichinosis in Ghurkas: specificity and sensitivity of enzyme-linked immunos or bent assays for IgM and IgE antibodies to Trichinella larval anti gens in diagnosis显示文摘 | Au AC Ko RC Simon JW | 1983 | Trans R Soc Trop Med Hyg1983，77，3： | 1 |
| 9 | Study of acute trichinosis in Ghurkas: specificity and sensitivity of enzyme-linked immunosorbent assays for IgM and IgE antibodies to Trichinella larval antigens in diagnosis 显示文摘 | Au AC Ko RC Simon JW | 1983 | Trans R Soc Trop Med Hyg1983，77，3： | 1 |
| 10 | Sequential disassembly of the cytoskeleton in BHK21 cells infected with vesicular stomatitis virus显示文摘 | Simon KO Whitaker-Dowling PA Youngner JS | 1990 | Virology1990，177，1： | 1 |
| 11 | Outage probability of diversity systems over generalized fading channels 显示文摘 | Y C Ko M S Alouini M K Simon | 2000 | IEEE Transactions on Commtmication2000，48，11： | 1 |
| 12 | Exotropic Drift and Ocular Alignment After Surgical Correction for Intermittent Exotropia显示文摘 | Leow Po-Lin Ko Simon T C Wu Patrick K W Chan Clement W N | 2010 | Journal of Pediatric Ophthalmology and Strabismus2010，，1： | 1 |
| 13 | Outageprobability of diversity systems over generalized fading channels 显示文摘 | Ko Y C Alouini M S Simon M K | 2000 | IEEE Transactions on Communications2000，48，11： | 1 |
| 14 | α-Actinin: a direct link between actln and iniegrins 显示文摘 | Pavalko FM Otey CA Simon KO | 1991 | Biochem Soc Trans1991，19，4： | 1 |
| 15 | Non-small-cell lung cancer with brain metastasis显示文摘 | Lillehei KO Simon J Gaspar L | 2004 | Oncology2004，18，14： | 1 |
| 16 | Study of acute trichinosis in Ghurkas:specificity and sensitivity of enzyme-linked immunosorbent assays for IgM and IgE antibodies to Trichinella larval antigens in diagnosis显示文摘 | Au AC Ko RC Simon JW | 1983 | Trans R Soc Trop Med Hyg1983，77，3： | 1 |
| 17 | Ultrasonic initiation of polystyrene latex synthesis 显示文摘 | Soo KO Simon B | 2000 | Ultraso Sonochem2000，7，： | 1 |
| 18 | Lucky dectron mode of channel hot - electron injection in MOSFET'S显示文摘 | Tam Simon Ko Ping- Keung Hu Chenming | 1984 | WEE Transactions on Electron Devices1984，31，9： | 1 |
| 19 | Exploratory study of understanding hotel employees' perception on work-life balance issues 显示文摘 | Simon Chak-keung Wong Annie Ko | 2009 | International Journal of Hospitality Management2009，28，2： | 1 |
| 20 | Factors influencing the failure of interferon-free therapy for chronic hepatitis C:Data from the Polish EpiTer-2 cohort study显示文摘BACKGROUND The introduction of direct-acting antiviral drugs into clinical practice has revolutionized the treatment of chronic hepatitis C,making it highly effective and safe for patients.However,few researchers have analyzed the factors causing therapy failure in some patients.AIM To analyze factors influencing the failure of direct antiviral drugs in the large,multicenter EpiTer-2 cohort in a real-world setting.METHODS The study cohort consisted of patients with chronic hepatitis C treated at 22 Polish centers from 2016-2020.Data collected from the online EpiTer-2 database included the following:hepatitis C virus(HCV)genotype,stage of fibrosis,hematology and liver function parameters,Child-Turcotte-Pugh and Model for End-stage Liver Disease scores,prior antiviral therapy,concomitant diseases,and drugs used in relation to hepatitis B virus(HBV)and/or human immunodeficiency virus(HIV)coinfections.Adverse events observed during the treatment and follow-up period were reported.Both standard and machine learning methods were used for statistical analysis.RESULTS During analysis,12614 patients with chronic hepatitis C were registered,of which 11938(mean age:52 years)had available sustained virologic response(SVR)data[11629(97%)achieved SVR and 309(3%)did not].Most patients(78.1%)were infected with HCV genotype 1b.Liver cirrhosis was diagnosed in 2974 patients,while advanced fibrosis(F3)was diagnosed in 1717 patients.We included patients with features of hepatic failure at baseline[ascites in 142(1.2%)and encephalopathy in 68(0.6%)patients].The most important host factors negatively influencing treatment efficacy were liver cirrhosis,clinical and laboratory features of liver failure,history of hepatocellular carcinoma,and higher body mass index.Among viral factors,genotype 3 and viral load also exerted an influence on treatment efficacy.Classical statistical analysis revealed that treatment ineffectiveness seemed to be influenced by the male sex,which was not confirmed by the multivariate analysis using the machine learning algorithm(random forest).Coinfection with HBV(including patients with on-treatment reactivation of HBV infection)or HIV,extrahepatic manifestations,and renal failure did not significantly affect the treatment efficacy.CONCLUSION In patients with advanced liver disease,individualized therapy(testing for resistance-associated variants and response-guided treatment)should be considered to maximize the chance of achieving SVR. | Ewa Janczewska Mateusz Franciszek Kołek Beata Lorenc Jakub Klapaczyński Magdalena Tudrujek-Zdunek Marek Sitko Włodzimierz Mazur Dorota Zarębska-Michaluk Iwona Buczyńska Dorota Dybowska Agnieszka Czauż-Andrzejuk Hanna Berak RafałKrygier Jerzy Jaroszewicz Jolanta Citko Anna Piekarska Beata Dobracka Łukasz Socha Zbigniew Deroń Łukasz Laurans Jolanta Białkowska-Warzecha Olga Tronina Brygida Adamek Krzysztof Tomasiewicz Krzysztof Simon Malgorzata Pawłowska Waldemar Halota Robert Flisiak | 2021 | World Journal of Gastroenterology2021，27，18： | 0 |
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