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您的检索式：作者名="Simon E.Lewis"
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| 1 | Intravenous infusion of magnesium sulfate is not associated with cardiovascular,liver,kidney,and metabolic toxicity in adults显示文摘Background:Magnesium(Mg)deficiency contributes to the pathophysiology of numerous diseases.The therapeutic use of Mg has steadily increased over time.The increased in-hospital use of intravenous(IV)magnesium sulfate(MgSO4)warrants more extensive investigation regarding the safety of the therapy.The aim of this study was to determine the safety of IV MgSO4 infusion on cardiovascular,liver,kidney,and metabolic markers in adults.Methods:Twelve volunteers were randomized to one of two cross-over conditions:(a)IV infusion of MgSO4 in 5%dextrose followed by IV infusion of 5%dextrose 1 week later or(b)IV infusion of 5%dextrose followed by IV infusion of MgSO4 in 5%dextrose 1 week later.An electrocardiogram was recorded continuously during the infusions.Blood was drawn pre-and post-infusion for blood count(high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,and triglycerides).Results:Serum Mg increased from pre-to post-infusion in the MgSO4+5%dextrose group(p<0.0001).The QRS interval length increased from pre-to post-infusion in the MgSO4+5%dextrose group(p<0.04).Additionally,serum glucose concentration increased in the MgSO4+5%dextrose group(p=0.04).These significant findings were modeled with gender and age as covariates.No other significant differences were found.Conclusions:The administration of IV infusion of MgSO4(4 g/100 mL)in 5%dextrose over a 4-hour treatment period poses no significant deleterious effects on cardiovascular,liver,kidney,or metabolic function.Relevance for patients:IV infusion of MgSO4 may be used for certain treatment indications without significant concern for systemic or organ toxicity. | Elisa Karhu Steven E.Atlas Jinrun Gao Syed A.Mehdi Dominique Musselman Sharon Goldberg Judi M.Woolger Raul Corredor Muhammad H.Abbas Leopoldo Arosemena Simone Caccamo Ashar Farooqi Janet Konefal Laura Lantigua Vanessa Padilla Ammar Rasul Eduard Tiozzo Oscar L.Higuera Andrea Fiallo John E.Lewis | 2018 | Journal of Clinical & Translational Research2018，4，1： | 0 |
| 2 | A simple,azulene-based colorimetric probe for the detection of nitrite in water显示文摘We describe the synthesis and evaluation of an azulene-based chemodosimeter for nitrite.The probe was found to undergo two distinct color changes upon introduction of aqueous nitrite ion.A near-instant formation of a grey color provides a qualitative indication of the presence of nitrite,followed by the formation of a deep-yellow/orange color,the endpoint from which quantitative data can be derived.The azulene probe exhibits 1:1 stoichiometry of reaction with nitrite in water,and is selective for nitrite over other anions.The azulene probe was applied to determine nitrite content in cured meat,and compared with the British Standard testing procedure(Griess test).The value obtained from the azulene-based probe agreed closely with the standard test.Our procedure only requires the preparation of one standard solution,instead of the three required for the standard Griess test. | Lloyd C.Murfin Carlos M.Lopez-Alled Adam C.Sedgwick Jannis Wenk Tony D.James Simon E.Lewis | 2020 | Frontiers of Chemical Science and Engineering2020，14，1： | 0 |
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