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16篇 您的检索式：作者名="Simon CF"

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		题名	作者	年代	出处	被引量
	1	ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease.	Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde	2014	World Journal of Gastroenterology2014，20，10：	2
	2	Normal variants of the cerebral circulation at multidetector CT angiography显示文摘	Simon D Kenneth CF	2009	Radiographics2009，29，4：	1
	3	Evolution,weighting,and phylogenetic utility of mitochondrial gene sequences and compilation of conserve polymerase chain reaction primers显示文摘	Simon CF Frati F Beckenbach A Crespi B Liu H and Flook P	1994	Ann Entomol Soc Am1994，87，：	1
	4	Three-dimensional color Doppler:a clinical study in patients with mitral regurgitation显示文摘	De Simone R Glombitza G Vahl CF	1999	J Am Coll Cardiol1999，33，5：	1
	5	Three-dimensional color Doppler techniques and clinical application显示文摘	De Simone R Glombitza G Vahl CF	1999	Eur Heart J1999，20，8：	1
	6	Three-dimensional color Doppler:a clinical study in patients with mitral regurgitation显示文摘	De Simone R Glombitza G Vahl CF	1999	J Am Coll Cardiol1999，33，6：	1
	7	Acquired von Wille- brand's syndrome in systemic lupus erythematosus显示文摘	Simone JV Comet JA Abildgaard CF	1968	Blood1968，31，6：	1
	8	Three-dimensional color Doppler reconstruction of intracardiac blood flow in patients with different heart diseases显示文摘	De Simone R Glombitza G Vahl CF	2000	Am J Cardiol2000，86，12：	1
	9	Three-dimensional color Doppler:a clinical study in patients with mitral regurgitation显示文摘	De Simone R Glombitza G Vahl CF	1999	J Am Coll Cardi- ol1999，33，：	1
	10	Evolution,weghting and phylogenetic ytility of mitochondrial gene sequences and a conpilation of conserved polymerase chain reaction primers 显示文摘	Simon CF Frati F Beckenbach A	1994	Ann Entomol Soc Am1994，87，：	1
	11	Prevalence of antibiotic resistance in drinking water treatment and distribution systems 显示文摘	Xi C Zhang Y Marrs CF Ye W Simon C Foxman B Nriagu J	2009	Appl Environ Microbiol2009，75，17：	1
	12	Wastewater treatment contributes to selective increase of antibiotic resistance among Acinetobacter spp显示文摘	Zhang YL Marrs CF Simon C	2009	Science of the Total Environment2009，407，12：	1
	13	Blood coagulation in thyroid dysfunction 显示文摘	Simone JV Abildgaard CF Schulman I	1965	N Engl J Med1965，273，20：	1
	14	Factors associated with condom use: economic security and positive prevention among people living with hiv/aids in the caribbean显示文摘	Allen CF Simon YE wards J	2010	AIDS Care2010，2201，：	1
	15	Three-dimensional col-or Dopple reconstruction of intracardic blood flow in patients withdifferent heart valve disease显示文摘	De Simone R Glombitza G Vahl CF	2000	Am J Cardiol2000，86，12：	1
	16	Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing 显示文摘	Paulo CF Simone CV Rogerio FN	2013	Clinics2013，68，9：	1

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