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| 1 | Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease显示文摘Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 years.Parkinson’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic neurons.In addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-synuclein.Although it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s disease.In addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative disorders.Among such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s disease.Environmental enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating neurotransmission.In this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic factors.We describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease. | Tamara Andrea Alarcón Sarah Martins Presti-Silva Ana Paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires | 2023 | Neural Regeneration Research2023，18，7： | 2 |
| 2 | On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes显示文摘 | SIMES S SLEPUSHKIN V DZGNES N | 2001 | Biochim Biophys Acta2001，1515，1： | 1 |
| 3 | On the formulation of pH-sensitive liposomes with long circulation times显示文摘 | SIMES S MOREIRA J N FONSECA C | 2004 | Adv Drug Deliv Rev2004，56，7： | 1 |
| 4 | Preliminary characterization of an experimental breast cancer cells brain metastasis mouse model by MRI/MRS显示文摘 | R. V. Sim?es A. Martinez-Aranda B. Martín S. Cerdán A. Sierra C. Arús | 2008 | Magnetic Resonance Materials in Physics Biology and Medicine2008，，4： | 1 |
| 5 | Para-metric analysis of the latera-l torsional buckling resistance ofsteel beams in case of fire显示文摘 | P M M Vila Real N Lopes L Sim es da Silva | 2007 | Fire Safety Journal2007，42，67： | 1 |
| 6 | On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes显示文摘 | Sim(o)es S Slepushkin V Düzgünes N | 2001 | Biochim Biophys Acta2001，1515，1： | 1 |
| 7 | Purification,biochemical and molecular analysis of a chymotrypsin protease with prophenoloxidase suppression activity from the entomopathogenic nematode Steinernema carpocapsae显示文摘 | Balasubramanian N Hao YJ Toubarro D Nascimento G Simōes N | | 0，，09： | 1 |
| 8 | Enhanced inhibition of HIV-1 replication in macrophages by antisense oligonucleotides,ribozymes and acyclic nucleoside phosphonate analogs delivered in pH-sensitive liposomes显示文摘 | Düzgünes N Sim(o)es S Slepushkin V | | 0，，4： | 1 |
| 9 | Liposome-mediated delivery of antiviral agents to human immunodeficiency virus-infected cells显示文摘 | Düzgünes N Pretzer E Sim(o)es S | | 0，，01： | 1 |
| 10 | Brain metabolitc differences in one-year-old infants born at term and association with neurodevelopmental outcome 显示文摘 | Sim~es RV Cruz-Lemini M Bargallo N | 2015 | Am J Obstet Gynecol2015，213，2： | 1 |
| 11 | First record of Ophioderma ensiferum (Echinodermata: Ophin- roidea) from the southeastern continental shelf of the Gulf of Mexico and from an anchialine cave 显示文摘 | Hern~mdez- Diaz YQ Solfs -Marin FA Sim es N | 2013 | Revista Mexicana De Biodiversidad2013，84，2： | 1 |
| 12 | Biochemical study and in vitro insect immune suppression by a trypsin-like secreted protease from the nematode Steinernema carpocapsae显示文摘 | BALASUBRAMANIAN N TOUBARRO D SIM?ES N | 2010 | Parasite Immunol2010，32，3： | 1 |
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