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| 1 | Cysteine proteases as therapeutic targets:does selectivity matter? A systematic review of calpain and cathepsin inhibitors显示文摘Cysteine proteases continue to provide validated targets for treatment of human diseases.In neurodegenerative disorders,multiple cysteine proteases provide targets for enzyme inhibitors,notably caspases,calpains,and cathepsins.The reactive,active-site cysteine provides specificity for many inhibitor designs over other families of proteases,such as aspartate and serine;however,a)inhibitor strategies often use covalent enzyme modification,and b)obtaining selectivity within families of cysteine proteases and their isozymes is problematic.This review provides a general update on strategies for cysteine protease inhibitor design and a focus on cathepsin B and calpain 1 as drug targets for neurodegenerative disorders;the latter focus providing an interesting query for the contemporary assumptions that irreversible,covalent protein modification and low selectivity are anathema to therapeutic safety and efficacy. | Marton Siklos Manel Ben Aissa Gregory R.J.Thatcher | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 11 |
| 2 | A Suggestion for a Simple Cross - Country Empirical Proxy for Trend Unemployment 显示文摘 | Stephen C Murchison Pierre L Siklos | 1999 | Applied Economics Letters1999，，6： | 1 |
| 3 | Cointegration and threshold ad- justment 显示文摘 | ] Enders W Siklos PL | 2001 | Journal of Business and Economic Statistics2001，，19： | 1 |
| 4 | Cointegration and threshold adjustment显示文摘 | Enders W and Siklos P | 2001 | Journal of Business and Eco- nomic Statistics2001，19，2： | 1 |
| 5 | Stereotaxic injection of IgG from patients with Alzheimer disease initiates injury of cholinergic neurons of the basal forebrain显示文摘 | Engelhardt J Le WD Siklos L | 2000 | Arch Neurol2000，57，： | 1 |
| 6 | Cointegration and Threshold Adjustment显示文摘 | Walter Enders Pierre L Siklos | 2001 | Journal of Business & Economic Statistics2001，，2： | 1 |
| 7 | Systematic Sampling, Temporal Aggrega- tion, Seasonal Adjustment, and Cointegration显示文摘 | Granger C W J Siklos P R | 1995 | Journal of Economet- tics1995，，1： | 1 |
| 8 | Intracellular calcium parallels motoneuron degeneration in SOD-1 mutant mice 显示文摘 | Siklos L Engelhardt J I Alexianu M E | 1998 | J Neuropathol Exp Neurol1998，57，6： | 1 |
| 9 | DL-Homocysteic acid application disrupts calcium homeostasis and induces degeneration of spinal motor neurons in vivo显示文摘 | Adalbert R Engelhardt JI Siklos L | | 0，，： | 1 |
| 10 | Secrets to the successful Hungarian bank privatization: the benefits of foreign ownership through strategic partnerships 显示文摘 | Abel I Siklos P | 2004 | Economic Systems2004，28，： | 1 |
| 11 | Regime-sensitive cointegration with an illustration from interest rate parity显示文摘 | Siklos P Granger C W J | 1997 | Macroeconomic Dynamics1997，1，3： | 1 |
| 12 | Communication for Multi-Taskers:Perspectives on Dealing with Both Monetary Policy and Financial Stability显示文摘 | Siklos Pierre | 2011 | Rimini Centre for Economic Analysis Working Paper Series2011，1104，： | 1 |
| 13 | What has driven Chinese monetary policy since 1990? Investigating the People’s bank’s policy rule显示文摘 | Richard C.K. Burdekin Pierre L. Siklos | 2008 | Journal of International Money and Finance2008，，5： | 1 |
| 14 | Income velocity and institutional change: some new time series evidence, 1870 - 1986 显示文摘 | Siklos P L | 1993 | Journal of Mon- ey Credit and Banking1993，25，31： | 1 |
| 15 | Foreign exchange market intervention in two small open economies: the Canadian and Australian experience显示文摘 | J.M. Rogers P.L. Siklos | 2003 | Journal of International Money and Finance2003，，3： | 1 |
| 16 | Institutional change and the velocity of money : a century of evidence 显示文摘 | Bordo M D Jonung Siklos P L | 1997 | Economic Inquiry1997，35，4： | 1 |
| 17 | Intracellular calcium redistribution accompanies changes in total tissue Na^+ , K^+ and water during the first two hours of in vitro incubation of hippocampal slices显示文摘 | Siklos L Kuhnt U Parducz A | 1997 | Neumscience1997，79，： | 1 |
| 18 | Presence of dendritic cells, MCP-1, and activated microglia / macrophages in amyotrophic lateral sclerosis spinal cord tissue 显示文摘 | Henkel JS Engelhardt JI Siklos L | 2004 | Ann Neurol2004，55，： | 1 |
| 19 | Institutional Chang and the Velocity of Money:A Century of Evedence显示文摘 | Bordo M D Jonung Lars Siklos P L | | 0，，04： | 1 |
| 20 | Chloride distribution in the CA1 region of newborn and adult hippocampus by light micro- scopic histochemistry显示文摘 | Barna B Kuhnt U Siklos L | 2001 | Histochem Cell Biol2001，115，2： | 1 |
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