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| 1 | Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo显示文摘 | SIGN TR SHANKAR S CHEN X | 2003 | Cancer Res2003，63，17： | 1 |
| 2 | aureus shock in immunodeficient adults with multiple myeloma显示文摘 | Kamel NS Banks MC Dosik A et aL Lack of signs of toxic shock syndrome when T cells are absent: S | 2002 | Clin Exp Immunol2002，128，1： | 1 |
| 3 | Modelling of aquifer response to time varying recharge and pumping from multiple basins and wells显示文摘 | Manglik A Rai S N Sign V | 2004 | Journal of Hydrology2004，292，1： | 1 |
| 4 | Psychosocial intervention for family caregivers of people with dementia reduces caregiver's burden:development and effect after 6 and 12 months显示文摘 | Signe A Elmstahl S | 2008 | Scand J Caring Sci2008，22，1： | 1 |
| 5 | Psychosocial intervention for family caregivers of people with dementia reduces caregiver's burden: development and effect after 6 and 12 months显示文摘 | Signe A Elmstahl S | 2008 | Scand J Caring Sci2008，22，1： | 1 |
| 6 | Lymphoplasmacytic lym- phoma and marginal zone lymphoma in the bone marrow, para- trahecuiar involvement as an important distinguishing feature 显示文摘 | Assia B Gunhild T Signe S | 2015 | AmJ ClinPathol2015，143，6： | 1 |
| 7 | Pictorial essay : susceptibility-weighted im- aging in cerebral ischemia 显示文摘 | with hyperdense artery sign on J Stroke Cerebmvase Dis 2008 Mitlal P Kalia V Dua S | 2010 | Indian J Radiol Imaging2010，20，4： | 1 |
| 8 | Cardiac and proinflammatory markers predict prognosis in cirrhosis显示文摘 | Signe Wiese Christian Mortensen Jens P. G?tze Erik Christensen Ove Andersen Flemming Bendtsen S?ren M?ller | 2014 | Liver Int2014，，6： | 1 |
| 9 | Impact of innova- tive practices in environmentally focused firms: Mode- rating factors显示文摘 | Ona S Signes P Garrigos A | 2011 | International Journal of Environmental Research2011，5，2： | 1 |
| 10 | Decoupling of invertible nonlinear systems with state feedback and precompensation显示文摘 | SIGN S N | 1980 | IEEE Transaction Automat Control1980，25，6： | 1 |
| 11 | Synergistic interactions of chemotherapeutic drugs and tumor necrosis facotr-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo显示文摘 | SIGN TR SHANKAR S CHEN X | 2003 | Cancer Res2003，63，17： | 1 |
| 12 | Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo显示文摘 | SIGN T R SHANKAR S CHEN X | 2003 | Cancer Res2003，63，： | 1 |
| 13 | Total silencing by intron-spliced hairpin RNAs显示文摘 | Smith N A Sign S P Wang M B | 2000 | Nature2000，407，： | 1 |
| 14 | The effects of a 20-week exercise program on blood-circulating biomarkers related to brain health in overweight or obese children:The ActiveBrains project显示文摘Background:Emerging research supports the idea that exercise positively affects neurodevelopment.However,the mechanisms linking exercise with brain health are largely unknown.We aimed to investigate the effect of exercise on(a)blood biomarkers selected based on previous evidence(brainderived neurotrophic factor,β-hydroxybutyrate(BHB),cathepsin B(CTSB),kynurenine,fibroblast growth factor 21(FGF21),soluble vascular cell adhesion molecule-1(sVCAM-1));and(b)a panel of 92 neurology-related proteins(discovery analysis).We also investigated whether changes in these biomarkers mediate the effects of exercise on brain health(hippocampal structure and function,cognitive performance,and mental health).Methods:We randomized 81 overweight/obese children(10.1±1.1 years,41%girls)into 2 groups:either 20 weeks of aerobic plus resistance exercise or control.Candidate biomarkers were assessed using enzyme-linked immunosorbent assay(ELISA)for kynurenine,FGF21,and CTSB;colorimetry forβ-hydroxybutyrate;and XMap for brain-derived neurotrophic factor and soluble vascular cell adhesion molecule-1.The92 neurology-related proteins were analyzed by an antibody-based proteomic analysis.Results:Our intervention had no significant effect on candidate biomarkers(all p>0.05).In the discovery analysis,a reduction in circulating macrophage scavenger receptor type-I was observed(standardized differences between groups=-0.3,p=0.001).This effect was validated using ELISA methods(standardized difference=-0.3,p=0.01).None of the biomarkers mediated the effects of exercise on brain health.Conclusions:Our study does not support a chronic effect of exercise on candidate biomarkers.We observed that while chronic exercise reduced the levels of macrophage scavenger receptor type-Ⅰ,it did not mediate the effects of exercise on brain health.Future studies should explore the implications of this novel biomarker for overall health. | María Rodriguez-Ayllon Abel Plaza-Florido Andrea Mendez-Gutierrez Signe Altmäe Patricio Solis-Urra Concepción M.Aguilera Andrés Catena Francisco B.Ortega Irene Esteban-Cornejo | 2023 | Journal of Sport and Health Science2023，12，2： | 0 |
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