|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 2 | Ultrasound-induced cell membrane porosity 显示文摘 | Deng CX Sieling F Pan H | 2004 | Ultrasound Med Biol2004，30，： | 1 |
| 3 | Growth and yield of winterwheat in the first 3 years of a monoculture under varying N fertilizationin NW Germany显示文摘 | Sieling K Stahl C Winkelmann C | 2005 | European Journal of Agronomy2005，22，： | 1 |
| 4 | CT of pituitary abscess显示文摘 | ENZMANN D R SIELING R J | 1983 | American Journal of Neuroradiology1983，4，1： | 1 |
| 5 | The human CD1-restrieted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens显示文摘 | Sieling PA Torrelles JB Stenger S | 2005 | J Immunol2005，174，5： | 1 |
| 6 | Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c显示文摘 | Sieling PA Porcelli SA Duong BT | 2000 | J Immunol2000，165，： | 1 |
| 7 | Reduction of OBDDs in line- ar time 显示文摘 | SIELING D WEGEBER I | 1993 | Information Processing Letters1993，48，3： | 1 |
| 8 | Short-Term Effects of Biogas Residue Application on Yield Performance and N Balance Parameters of Maize in Different Cropping Systems 显示文摘 | HERRMANN A SIELING K WIENFORTH B | 2013 | Journal of Agricultural Science2013，151，4： | 1 |
| 9 | Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens显示文摘 | Garcia VE Sieling PA Gong JH | 1997 | J Immunol1997，159，3： | 1 |
| 10 | The role of Toll-like receptors in host defense against microbial infection 显示文摘 | Sieling PA Modlin RL | 2001 | Curr Opin Immunol2001，13，1： | 1 |
| 11 | Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis显示文摘 | Schaible UE Winau F Sieling PA | 2003 | Nat Med2003，9，8： | 1 |
| 12 | Bacterial lipopolysaccharide activates NF-kB through toll-like receptor 4 (TLR4) in cultured human dermal endothelial cells different expression of TLR4 and TLR2 in the endothelial cells显示文摘 | Fature E Equils Q Sieling P A | 2000 | J Biol Chem2000，275，： | 1 |
| 13 | Effect of various factors on the utilization of nitrogen and iron by Spirodela polyrrhiza 显示文摘 | Bitcover E H Sieling D H | 1951 | Plant Physiology1951，26，： | 1 |
| 14 | Binary decision diagrams in theory and practice 显示文摘 | Drechsler R and Sieling D | 2001 | International Journal on Software Tools for Technology Transfer2001，3，2： | 1 |
| 15 | Structural differences in lipomannans from pathogenic and nonpathogenic mycobacteria that impact CDlb-rcstricted T cell responses显示文摘 | Torrelles JB Sieling PA Arcos J | 2011 | J Biol Chem2011，286，35： | 1 |
| 16 | Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens 显示文摘 | Garcia VE Sieling PA Gong J | 1997 | J Immunol1997，159，3： | 1 |
| 17 | Bacterial lipopolysaccharide activates NF-κB through Toll-like receptor 4(TLR-4) in cultured human dermal endothelial cells显示文摘 | Faure E Equils O Sieling PA | | 0，，15： | 1 |
| 18 | Toll-like receptors: mammalian 'taste receptors' for a smorgasbord of microbial invaders显示文摘 | Modlin RL | 2002 | Curr Opin Microbiol2002，5，1： | 1 |
| 19 | Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CDlc 显示文摘 | Porcelli S A Duong B T | 2000 | J Immunol2000，165，： | 1 |
| 20 | Human doublenegative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c显示文摘 | Sieling PA Porcelli SA Duong BT | 2000 | J Immunol2000，165，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员