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| 1 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 2 | Catalytic conversion of lignocellulosic biomass into chemicals and fuels显示文摘In the search of alternative resources to make commodity chemicals and transportation fuels for a low carbon future,lignocellulosic biomass with over 180-billion-ton annual production rate has been identified as a promising feedstock.This review focuses on the state-of-the-art catalytic transformation of lignocellulosic biomass into value-added chemicals and fuels.Following a brief introduction on the structure,major resources and pretreatment methods of lignocellulosic biomass,the catalytic conversion of three main components,i.e.,cellulose,hemicellulose and lignin,into various compounds are comprehensively discussed.Either in separate steps or in one-pot,cellulose and hemicellulose are hydrolyzed into sugars and upgraded into oxygen-containing chemicals such as 5-HMF,furfural,polyols,and organic acids,or even nitrogen-containing chemicals such as amino acids.On the other hand,lignin is first depolymerized into phenols,catechols,guaiacols,aldehydes and ketones,and then further transformed into hydrocarbon fuels,bioplastic precursors and bioactive compounds.The review then introduces the transformations of whole biomass via catalytic gasification,catalytic pyrolysis,as well as emerging strategies.Finally,opportunities,challenges and prospective of woody biomass valorization are highlighted. | Weiping Deng Yunchao Feng Jie Fu Haiwei Guo Yong Guo Buxing Han Zhicheng Jiang Lingzhao Kong Changzhi Li Haichao Liu Phuc T.T.Nguyen Puning Ren Feng Wang Shuai Wang Yanqin Wang Ye Wang Sie Shing Wong Kai Yan Ning Yan Xiaofei Yang Yuanbao Zhang Zhanrong Zhang Xianhai Zeng Hui Zhou | 2023 | Green Energy & Environment2023，8，1： | 6 |
| 3 | Hypothalamic-Pituitary-End-Organ Axes:Hormone Function in Female Patients with Major Depressive Disorder显示文摘Classic hypothalamic-pituitary-end-organ feedback loops–the hypothalamic-pituitary-adrenal axis(HPAA),hypothalamic-pituitary-thyroidal axis(HPTA),and hypothalamic-pituitary-gonadal axis(HPGA)–are associated with the neuroendocrine and immune systems in major depressive disorder(MDD).Female patients with MDD present with evident neuroendocrine and immunological changes.Glucocorticoid,thyroid hormone,and reproductive steroid levels fluctuate with menstrual cycles,which might lead to glucocorticoid receptor resistance,impairment of triiodothyronine conversion,and sex hormone secretion disorders.In this review,we summarize the independent and interactive functions of these three axes in female MDD patients.The similar molecular structure of steroids implies an interrelationship between the hypothalamic-pituitary-end-organ axes and the competitive inhibitory effects at the receptor level,especially when considering the HPAA and HPGA. | Yuncheng Zhu Xiaohui Wu Rubai Zhou Oliver Sie Zhiang Niu Fang Wang Yiru Fang | 2021 | Neuroscience Bulletin2021，37，8： | 3 |
| 4 | Effect of esmolol and lidocaine on agitation in awake phase of anesthesia among children:a double-blind,randomized clinical study显示文摘Background:Sevoflurane is widely used to anesthetize children because of its rapid action with minimal irritation of the airways.However,there is a high risk of agitation after emergence from anesthesia.Strabismus surgery,in particular,can trigger agitation because patients have their eyes covered in the postoperative period.The aim of this study was to determine whether or not esmolol and lidocaine could decrease emergence agitation in children.Methods:Eighty-four patients aged 3 to 9 years undergoing strabismus surgery were randomly assigned to a control group(saline only),a group that received intravenous lidocaine 1.5 mg/kg,and a group that received intravenous esmolol 0.5 mg/kg and lidocaine 1.5 mg/kg.Agitation was measured using the objective pain score,Cole 5-point score,and Richmond Agitation Sedation Scale score at the end of surgery,on arrival in the recovery room,and 10 and 30 min after arrival.Results:The group that received the combination of esmolol and lidocaine showed lower OPS and RASS scores than the other two groups when patients awoke from anesthesia(OPS=0(0-4),RASS=-4[(-5)-1])and were transferred to the recovery room(OPS=0(0-8),RASS=-1[(-5)-3])(P<0.05).There was no significant difference in the severity of agitation among the three groups at other time points(P>0.05).Conclusions:When pediatric strabismus surgery is accompanied by sevoflurane anesthesia,an intravenous injection of esmolol and lidocaine could alleviate agitation until arrival in the recovery room. | Jae Young Ji Jin Soo Park Ji Eun Kim Da Hyung Kim Jin Hun Chung Hea Rim Chun Ho Soon Jung Sie Hyeon Yoo | 2019 | Chinese Medical Journal2019，，7： | 3 |
| 5 | 基于RGB-D数据的自适应局部时空特征提取方法显示文摘对于一次学习手势识别,噪声和全局经验运动约束严重影响时空特征的精确与充分提取,为此提出了一种融合颜色和深度(RGB-D)信息的自适应局部时空特征提取方法.首先建立连续两灰度帧和两深度帧的金字塔以及相应的光流金字塔作为尺度空间.然后根据灰度和深度光流的水平与垂直方差自适应提取运动感兴趣区域(motion regions of interest,MRo Is).接着仅在MRo Is内检测角点作为兴趣点,当兴趣点的灰度和深度光流同时满足局部运动约束时即为关键点,局部运动约束是在每个MRo I内自适应确定的.最后在改进的梯度运动空间计算SIFT-like描述子.Chalearn数据库上的实验结果表明:提出方法得到了较高的识别准确率,其识别性能优于现已发表的方法. | 林佳 阮晓钢 于乃功 Ouattara Sie 朱晓庆 | 2016 | 北京工业大学学报2016，42，11： | 3 |
| 6 | Relationship between seminal plasma zinc concentration and spermatozoa-zona pellucida binding and the ZP-induced acrosome reaction in subfertile men显示文摘 | De-Yi Liu Boon-Shih Sie Ming-Li Liu Franca Agresta HW Gordon Baker | 2009 | Asian Journal of Andrology2009，11，4： | 2 |
| 7 | Intermediate to Long-Term Results of Radiofrequency Modified Maze Procedure as an Adjunct to Open-Heart Surgery显示文摘 | Willem P. Beukema Hauw T. Sie Anand R. Ramdat Misier Peter Paul H.M. Delnoy Hein J.J. Wellens Arif Elvan | 2008 | The Annals of Thoracic Surgery2008，，5： | 2 |
| 8 | Mesomorphic behavior of new benzothiazole liquid crystals having Schiff base linker and terminal methyl group显示文摘heterocycles 的一个相应系列, 6-methyl-2-(4-alkoxybenzylidenamino ) benzothiazoles,被综合并且描绘了使用英尺红外, 1H 和 13C NMR 和集体度谱的分析。二形互变的 nematic 阶段为更矮的成员被观察。近晶的 A 阶段仅仅向前从 octyloxy 衍生物出现了。在 benzothiazole 碎片和 Schiff 基础连接的终端甲基组影响了现在的系列的具有由中胚叶发达的行为。 | Sie Tiong Ha Kok Leei Foo Hong Cheu Lin Masato M.Ito Kazuma Abe Kenji Kunbo S.Sreehari Sastry | 2012 | Chinese Chemical Letters2012，23，7： | 2 |
| 9 | successful radiofrequency ablation in patients with previous atrial fibrillation results in a significant decrease in left atrial size 显示文摘 | BeukemaWP Elvan A Sie HT | 2005 | Circulation2005，112，： | 1 |
| 10 | The shell middle distillate synthesis process (SMDS)显示文摘 | Eilers J Posthuma S A Sie S T | 1990 | Catalysis Letters1990，7，14： | 1 |
| 11 | Inhibition of tissue factor synthesis by disruption of ERK kinases and PKC signaling pathways in human vascular SMCs显示文摘 | Xuereb JM Sie P Boneu B | 2000 | Thromb Haemost2000，84，： | 1 |
| 12 | Identifying the regulative role of NF-kappaB binding sites within promoter region of human matrix metalloproteinase 9 (MMP-9) by TNF-alpha induction显示文摘 | Wu HT Sie SS Kuan TC | 2013 | Appl Biochem Biotechnol2013，169，： | 1 |
| 13 | Evaluation of Renal Graft Function based on Standard Mathematical Formulas显示文摘 | SIEKO J JASICZEK A PaCZEK L | 2014 | Ann Transplant2014，19，： | 1 |
| 14 | The shell middle distillate synthe- sis process (SMDS) 显示文摘 | Eilers J Posthuma S A Sie S T | 1990 | Catalysis Letters1990，7，1234： | 1 |
| 15 | Progress in the catalysis of the upgrading of petroleum residue: A review of 25 years of R&D on Shell's residue hydroconversion technology显示文摘 | OELDERIK J M SIE S T BODE D | 1989 | Appl Catal1989，47，1： | 1 |
| 16 | Conversion of natural gas to transportation fuels via the Shell Middle Distillate Synthesis process (SMDS) 显示文摘 | Sie S T Senden M M G Van Wechem H M H | 1991 | Catalysis Today1991，8，3： | 1 |
| 17 | An Institutional Innovation for Agricultural Technology Adaptation and Adoption: Rice in West and Central Africa显示文摘 | Sidi Sanyang Moussa Sie Aliou Diagne Marie-Noelle Ndjiondjop Dogbe Selome Yawovi Mamadou MBare Coulibaly Patrice Ygue Adegbola | 2012 | Journal of Sociology Study2012，2，11： | 1 |
| 18 | Successful radiofrequency ablation in patients with previous atrial fibrillation results in a significant decrease in left atrial size显示文摘 | BEUKEMA W P ELVAN A SIE H T | 2005 | Circulation2005，112，： | 1 |
| 19 | Hydrodynamics of gas-liquid countercurrent flow in internally-finned monolithic structures显示文摘 | Lebens P J M van der Meijden R Edvinsson R K Kapteyn F Sie S T Moulijn J A | 1997 | Chem Eng Sci1997，52，2122： | 1 |
| 20 | Concentration of the phytoalex in resvertrol in wine 显示文摘 | SIE MANN E H CREASY L L | 1992 | Am Jenol Vitic1992，43，1： | 1 |
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