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| 1 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 2 | Asialo GM1-positive liver-resident CD8 T cells that express CD44 and LFA-1 are essential for immune clearance of hepatitis B virus显示文摘Persistent hepatitis B virus(HBV)infection results in chronic liver diseases that may progress to chronic hepatitis,liver cirrhosis,and subsequent hepatocellular carcinoma.Previous studies demonstrated that adaptive immunity,in particular CD8 T cells,is critical in HBV elimination.Recent studies have revealed a distinct tissue-localized T cell lineage,tissue-resident memory(TRM)cells,that is crucial for protective immunity in peripheral tissues.In this study,we showed that treatment with an anti-asialo GM1(ASGM1)antibody(Ab),which depletes NK cells,led to impairment of HBV clearance in a mouse animal model.Unexpectedly,the ability to clear HBV was not significantly impaired in NFIL3 KO mice,which are deficient in NK cells,implying that other non-NK ASGM1-positive immune cells mediate HBV clearance.We isolated intrahepatic ASGM1-positive cells from NFIL3 KO mice and analyzed the immune phenotype of these cells.Our results demonstrated a distinct population of CD44+LFA-1hi CD8 T cells that were the major intrahepatic ASGM1-positive immune cells in NFIL3 KO mice.Importantly,transcriptome analysis revealed that these ASGM1-positive CD8 T cells had distinct gene profiles and shared a similar core gene signature with TRM cells.In addition to both transcriptional and phenotypic liver residency characteristics,ASGM1-positive CD8 T cells were able to home to and be retained in the liver after adoptive transfer.Taken together,our study results indicate that these ASGM1-positive liver-resident CD8 T cells are the major effector immune cells mediating anti-HBV immunity. | Chi-Chang Sung Jau-Hau Horng Shih-Hong Siao I-Tsu Chyuan Hwei-Fang Tsai Pei-Jer Chen Ping-Ning Hsu | 2021 | Cellular & Molecular Immunology2021，18，7： | 3 |
| 3 | Arabidopsis Synaptotagmin 2 Participates in Pollen Germination and Tube Growth and Is Delivered to Plasma Membrane via Conventional Secretion显示文摘Arabidopsis synaptotagmin (SYT2 ) 2 被报导了在体的房间参予一条异乎寻常的能分泌的小径。我们的结果证明 SYT2 主要在 Arabidopsis thaliana 的花粉被表示。展出的 syt2 T-DNA 和 RNA 干扰异种线的花粉减少了全部的萌芽并且阻碍了花粉试管生长。在 SYT2 对不同、补缀的分隔空间局部性,但是能与 Golgi 标记, BODIPY TR C5 ceramide 和 GmMan1-mCherry 共同本地化的花粉 tubeindicates 的 SYT2-GFP 熔化蛋白质的表示的分析。然而,对在 Arabidopsis 暂停房间的血浆膜局部性的 SYT2-DsRed-E5was,除了 Golgi 仪器。在血浆膜的 SYT2 的本地化被在花粉试管染色的 immunofluorescence 进一步支持。而且, brefeldin Atreatment 禁止了 SYT2 的运输到血浆膜并且引起了 SYT2 聚集并且形成扩大分隔空间。SYT2-C2AB 领域的截断也在 Golgi 仪器导致了 SYT2 的保留。phospholipid 有约束力的试金显示出的 invitro SYT2-C2AB 领域以一种钙依赖者方式绑在 phospholipid 膜。一起拿,我们的结果显示了那 SYT2 为花粉萌芽和花粉试管生长被要求,并且涉及常规 exocytosis。 | Hui Wang Shengcheng Han Wei Siao Chunqing Song Yun Xiang Xiaorong Wu Pengyu Cheng Hongjuan Li JAn Jasik Karol Micieta JAn Turna Boris Voigtt Frantisek Baluska Jin Liu Yingdian Wang Heping Zhao | 2015 | Molecular Plant2015，8，12： | 2 |
| 4 | Impact of forest fires on regional air quality in Southeast Asia显示文摘 | Rajasekhar Balasubramanian Siao Wee See | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 2 |
| 5 | Projected Changes in Extreme High Temperature and Heat Stress in China显示文摘High temperature accompanied with high humidity may result in unbearable and oppressive weather. In this study,future changes of extreme high temperature and heat stress in China's Mainland are examined based on daily maximum temperature(T_x) and daily maximum wet-bulb globe temperature(T_w). T_w has integrated the effects of both temperature and humidity. Future climate projections are derived from the bias-corrected climate data of five general circulation models under the Representative Concentration Pathways(RCPs) 2.6 and 8.5 scenarios. Changes of hot days and heat waves in July and August in the future(particularly for 2020-50 and 2070-99), relative to the baseline period(1981-2010), are estimated and analyzed. The results show that the future T_x and T_w of entire China will increase by 1.5-5℃ on average around 2085 under different RCPs. Future increases in T_x and T_w exhibit high spatial heterogeneity, ranging from 1.2 to 6℃ across different regions and RCPs. By around 2085, the mean duration of heat waves will increase by 5 days per annum under RCP8.5. According to T_x, heat waves will mostly occur in Northwest and Southeast China, whereas based on T_w estimates, heat waves will mostly occur over Southeast China and the mean heat wave duration will be much longer than those from T_x. The total extreme hot days(T_x or T_w > 35℃) will increase by 10-30 days. Southeast China will experience the severest heat stress in the near future as extreme high temperature and heat waves will occur more often in this region, which is particularly true when heat waves are assessed based on T_w. In comparison to those purely temperature-based indices, the index T_w provides a new perspective for heat stress assessment in China. | Xingcai LIU Qiuhong TANG Xuejun ZHANG Siao SUN | 2018 | Journal of Meteorological Research2018，32，3： | 2 |
| 6 | Helicobacter pylori : Evidence-Based Review with a Focus on Immigrant Populations显示文摘 | Derrick Siao Ma Somsouk | 2014 | Journal of General Internal Medicine2014，，3： | 2 |
| 7 | Large scale identification, mapping, and genotyping of single nucleotide polymorphisms in the human genome显示文摘 | Wang DG Fan JB Siao CJ | 1998 | Science1998，280，5366： | 1 |
| 8 | Large-scale identification,mapping,and genotyping of single-nucleotide polymorphisms in the human genome显示文摘 | Wang DG Fan JB Siao C J | 1998 | Science1998，280，5366： | 1 |
| 9 | Large-scale identification,mapping,and genotyping of single-nucleotide polymorphisms in the human genome显示文摘 | Wang D G Fan J-B Siao C-J | 1998 | Science1998，280，5366： | 1 |
| 10 | Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II 显示文摘 | Siao CJ Tsirka SE | 2002 | J Neurosci2002，22，9： | 1 |
| 11 | Comparation of he relative activities of α-Tocopherol and PMC on platelet aggregation and antioxidative activity显示文摘 | JR Sheu C R Lee G H siao | 2003 | Life Sciences2003，34，11： | 1 |
| 12 | Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome 显示文摘 | Wang DG Fan JB Siao CJ | 1998 | Science1998，280，： | 1 |
| 13 | Large-scale identification,mapping,and genotyping of single nucleotide polymorphisms in the human genome显示文摘 | Fan J B Siao C J | 1998 | Science1998，280，： | 1 |
| 14 | Optimal management of an aneurysmal subarachnoid hemorrhage in a patient with known factor Ⅺ deficiency:a case report显示文摘 | Siao D Seetapah A Ryman A | | 0，，1： | 1 |
| 15 | Largescale identification, mapping, and genotyping of singlenucleotide polymorphisms in the human genome 显示文摘 | Wang D G Fan J B Siao C J | 1998 | Science1998，280，： | 1 |
| 16 | Genetic variant BDNF(Val66Met)polymorphism alters anxiety-related behavior显示文摘 | Chen ZY Jing D Bath KG Ieraci A Khan T Siao CJ | 2006 | Science2006，314，5796： | 1 |
| 17 | In Vitro binding of heavy metals by an edible biopolymer poly-γ-glutamic acid显示文摘 | SIAO F Y LU J F WANG J S | 2009 | J Agr Food Chem2009，57，2： | 1 |
| 18 | Large-scale identification, mapping,and genotyping of single-nucleotide polymorphisms in the human genome 显示文摘 | Wang DG Fan JB Siao CJ | 1998 | Science1998，280，5366： | 1 |
| 19 | Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model 显示文摘 | Di Giorgio FP Carrasco MA Siao MC | 2007 | Nat Neurosci2007，10，5： | 1 |
| 20 | Neuronal Release of ProBDNF显示文摘 | Yang J Siao C J Nagappan G | 2009 | Nat Neurosci2009，12，15： | 1 |
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