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| 1 | A Simulator for Producing of High Flux Atomic Oxygen Beam by Using ECR Plasma Source显示文摘In order to study the atomic oxygen corrosion of spacecraft materials in low earth orbit environment, an atomic oxygen simulator was established. In the simulator, a 2.45 GHz microwave source with maximum power of 600 W was launched into the circular cavity to generate ECR (electron cyclotron resonance) plasma. The oxygen ion beam moved onto a negatively biased Mo plate under the condition of symmetry magnetic mirror field confine, then was neutralized and reflected to form oxygen atom beam. The properties of plasma density, electron temperature, plasma space potential and ion incident energy were characterized. The atomic oxygen beam flux was calibrated by measuring the mass loss rate of Kapton during the atomic 5~30 eV and a cross section of φ80 mm could be obtained under the operating pressure of 10-1~10-3 Pa. Such a high flux source can provide accelerated simulation tests of materials and coatings for space applications. | Shuwang DUO, Meishuan LI and Yaming ZHANGShenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2004 | Journal of Materials Science & Technology2004，20，6： | 7 |
| 2 | Transdermal permeation of Zanthoxylum bungeanum essential oil on TCM components with different lipophilicity显示文摘Objective:To investigate the percutaneous penetration enhancement effect of essential oil from Zanthoxylum bungeanum Maxim.(Z.bungeanum oil)on active components in externally-applied traditional Chinese medicines.Methods:Five model drugs,geniposide,puerarin,ferulic acid,tetramethylpyrazine,and osthole,were chosen based on their lipophilicity and tested using in vitro transdermal permeation studies consisting of Franz diffusion cells and full thickness rat abdominal skin.Scanning electron microscopy was employed to observe the morphological changes of rat skin tissue after treatment with Z.bungeanum oil.The molecular interactions between the oil and the polar head groups in stratum corneum(SC)lipids were monitored using molecular dynamic simulation,and the SC/vehicle partition coefficients and saturation solubilities of the selected model drugs treated with and without the oil were also determined to ascertain its mechanisms of action.Results:As oil concentration increased,the log ERflow trended toward a negative linear relationship with the lipophilicity of drugs.After treatment with Z.bungeanum oil,a mild lifting up and wrinkle on the SC surface were observed,and appeared to become more pronounced as oil concentration increased.There was no significant difference between the control and the Z.bungeanum oil at different concentrations in terms of saturation solubility of GP,while saturation solubilities of the 4 other drugs gradually increased as oil concentration increased.The oxygen-containing constituents in Z.bungeanum oil,such as terpinen-4-ol and 1,8-cineole,which accounted for 57.95%of total oil,could form stable hydrogen bonds with the polar head group of ceramide 3.Conclusion:Z.bungeanum oil facilitated transdermal permeation of drugs with different lipophilicity,including the extremely hydrophilic and lipophilic drugs,whereas it exhibited greater enhancement activity for strongly hydrophilic drugs.The mechanisms of transdermal permeation enhancement by the oil could be explained with SC/vehicle partition coefficient,saturation solubility,and the interactions with SC lipids. | Yi Lan Jingyan Wang Shuwang He Shuying Li Peng Tan Hongmei Lin Qing Wu | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，3： | 6 |
| 3 | Settlement and Stability Analysis on Soft Clay Under Cyclic Loading显示文摘The results of undrained cyclic triaxial tests on three types of clays are collected and a relationship among the accumulated strain, the initial stress state, cyclic stress in the soil, as well as the number of cycles is established based on the experimental data. With this relationship, a procedure is proposed for subsidence and stability analysis on soft clay under the action of cyclic loads. | Yan Shuwang , Yang Jinliang Yan Chi Professor, Tianjin University, 300072 TianjinAssoc. Professor, Tianjin University, 300072 Tianjin Lecturer, Tianjin University, 300072 Tianjin | 1992 | China Ocean Engineering1992，7，4： | 3 |
| 4 | Distinct proteins in cortex of rats with closed traumatic brain injury detected by a WCX-2 protein chip显示文摘BACKGROUND: Mechanical injury can cause the changes of polygene expression spectrum in rat cerebral cortical nerve cells,and then result in the changes of intracellular protein expression. At present,dielectrophoresis is combined with mass spectrum technique to detect the expression of different proteins in rat cortex after brain injury,but the protein chip technique requires further investigation. OBJECTIVE: To analyze the differences of protein expression spectrum in rat cerebral cortex before and after closed traumatic brain injury using WCX-2 protein chip technique. DESIGN: A randomized controlled animal experiment. SETTING: Training Division of the Medical College of Chinese People's Armed Police Force. MATERIALS: Seventy-two male SD rats of clean degree,350-450 g,were provided by the Experimental Animal Center,Academy of Military Medical Sciences of Chinese PLA. Urea,trifluoroacetic acid,CHAPS and Tris (Sigma,USA); WCX-2 (Ciphergen,USA). Ultra-high speed hypothermia centrifuger (Bechman,USA); Rotary tissue microtome (Keuca,Germany); Biochip processor and PBSⅡ-C protein chip reader (Ciphergen,USA). METHODS: The experiments were carried out in the Institute of Molecular Pathology,Central Laboratory,and Department of Pathology,Medical College of Chinese People's Armed Police Force from June 2005 to March 2006. ① Grouping and treatment: The experiments were completed in molecular pathological institute,central laboratory and pathological department. ① The rats were randomly divided into control group (n =12) and brain injury group (n =60). Marmarou's weight-dropping models were duplicated at different time points in the brain injury group. In the control group,the rats were only treated by incising the skin of head top,without fixing the stainless steel hitting backup plate at the vault of skull,and obtain brain cortex for pathological and protein chip research,and they were killed after 24 hours. The rats in the brain injury group were killed at 4,8,12,24 and 48 hours after model establishment. ② Pathological observation: Longitudinal section was made on cerebral cortex,and sections of 5 μm were prepared,then stained with hematoxylin and eosin (HE). ③ Protein chip analysis: 100 mg cerebral cortex was collected from each rat,and the protein content in sample was detected with Bradford method,meanwhile,WCX-2 protein chip was used to analyze the protein spectrum. The data were automatically collected with Ciphergen proteinchip 3.0 software,and the results were analyzed using Biomarker Wizard software to compare the differences of protein spectrum in rat cortex between the groups. MAIN OUTCOME MEASURES: Results of the pathological observation of cerebral cortex and the protein spectrum analysis. RESULTS: ① Pathological changes of cerebral cortex: In the control group,no necrosis and edema was observed. In the brain injury group,injures of different severity occurred at different time points; After 4 hours,focal or scattered red nerve cells could be observed,the size of some cells was increased,cytoplasm was lightly stained,and only nuclear fragments were seen; After 8 hours,the necrotic nerve cells were increased,and the number of nerve cells was reduced,astrocytes (neuronophagia) could be seen in partial cytoplasm; there was small vascular dilatation,and endothelial cell proliferation; interstitial edema,regional rarefaction lightly stained. After 12-48 hours,the necrotic nerve cells were reduced,and astrocytes proliferated. ② Results of protein spectrum analysis: The WCX-2 experiment found that the expressions of 5 639,3 212 and 7 536 u proteins in cerebral cortex changed after injury in the brain injury group. The peak intensity of 5 639 u protein in the brain injury group at 8 hours after injury was higher than that in the control group (P < 0.05); The peak intensity of 3 212 u protein in the brain injury group at 48 hours after injury was higher than that in the control group (P < 0.05); The peak intensity of 7 536 u protein at 24 hours after injury was higher than that in the control group (P < 0.05). CONCLUSION: Brain injury can cause the changes of protein expression spectrum in cerebral cortex,it is suggested that brain injury can induce the expression of protein. | Li Zhan Lin Liang Qingming Shu Shuwang Yang Yongliang Zhang | 2007 | Neural Regeneration Research2007，2，6： | 3 |
| 5 | Cumulative Deformation of Soft Clay Under Cyclic Loading显示文摘Reconstituted specimens are prepared by means of vacuum preloading. Both static and cyclic triaxial tests are carried out, with the specimens consolidated under different principal stress ratios. A finite element method is put forward for calculating the cumulative deformation of soft clay under cyclic loading. | Yan, Shuwang Yan, Chi Zhang, Jianguo | 1993 | China Ocean Engineering1993，8，3： | 3 |
| 6 | Stability Analysis of Bohai Oil-Drilling Ship No. 6 Under Static and Cyclic Loads显示文摘- This paper presents a procedure to calculate the safety factor against sliding of a marine gravity structure subjected to a combination of static and cyclic loads. This procedure claculates the stress at the sliding surface by the finite element method (FEM) and takes the dynamic properties of clay into account. With this procedure, the stability of a Bohai oil-drilling ship is analyzed. The calculated safety factor is much smaller than 1, indicating that this oil-drilling ship would fail just as what had happened to it. | Qiu Changlin Yan Shuwang Graduate student, Dept. of Hydraulic Engrg., Tianjin University . Professor, Dept. of Hydraulic Engrg., Tianjin University | 1996 | China Ocean Engineering1996，11，4： | 3 |
| 7 | Quantitative prediction of the bitterness of atomoxetine hydrochloride and taste-masked using hydroxypropyl-β-cyclodextrin:A biosensor evaluation and interaction study显示文摘The bitterness of a drug is a major challenge for patient acceptability and compliance,especially for children.Due to the toxicity of medication,a human taste panel test has certain limitations.Atomoxetine hydrochloride(HCl),which is used for the treatment of attention deficit/hyperactivity disorder(ADHD),has an extremely bitter taste.The aim of this work is to quantitatively predict the bitterness of atomoxetine HCl by a biosensor system.Based on the mechanism of detection of the electronic tongue(Etongue),the bitterness of atomoxetine HCl was evaluated,and it was found that its bitterness was similar to that of quinine HCl.The bitterness threshold of atomoxetine HCl was 8.61μg/ml based on the Change of membrane Potential caused by Adsorption(CPA)value of the BT0 sensor.In this study,the taste-masking efficiency of 2-hydroxypropyl-β-cyclodextrin(HP-β-CyD)was assessed by Euclidean distances on a principle component analysis(PCA)map with the SA402B Taste Sensing System,and the host–guest interactions were investigated by differential scanning calorimetry(DSC),powder X-ray diffraction(XRD),nuclear magnetic resonance(NMR)spectroscopy and scanning electron microscopy(SEM).Biosensor evaluation and characterization of the inclusion complex indicated that atomoxetine HCl could actively react with 2-hydroxypropyl-β-cyclodextrin. | Shuying Li Ying Zhang Abdur Rauf Khan Shuwang He Yingxin Wang Jiangkang Xu Guangxi Zhai | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，4： | 2 |
| 8 | Two-dimensional gel electrophoresis and surface-enhanced laser desorption ionization-time of flight-mass spectrometry for detection of protein expression profiles in the hippocampus following closed brain injury显示文摘Gene expression profile changes in brain regions following traumatic brain injury at the gene level cannot sufficiently elucidate gene expression time,expression amount,protein post-translational processing or modification.Therefore,it is necessary to quantitatively analyze the gene expression profile using proteomic techniques.In the present study,we established a rat model of closed brain injury using Marmarou's weight-drop device,and investigated hippocampal differential protein expression using two-dimensional gel electrophoresis and surface-enhanced laser desorption ionization-time of flight-mass spectrometry.A total of 364 protein peaks were detected on weak cation exchange-2 protein chips,including 37 differential protein peaks.345 protein peaks were detected on immobilized metal affinity capture arrays-Cu,including 12 differential protein peaks Further examination of these differential proteins revealed that glucose-regulated protein and proteasome subunit alpha type 3 expression were significantly upregulated post-injury.These results indicate that brain injury can alter protein expression in the hippocampus,and that glucose-regulated protein and proteasome subunit alpha type 3 are closely associated with the occurrence and development of traumatic brain injury. | Qingming Shu Zhiqiang Li Shuwang Yang Lingzhi Li Xiao Bai Yongliang Zhang | 2010 | Neural Regeneration Research2010，5，23： | 2 |
| 9 | Improvement on the Oxidation Resistance of a Ti_3Al Based Alloy by Cr1-xAl_xN (0≤x≤0.47) Coatings显示文摘Cr_( 1-x ) Al_xN 涂层在由在 800-900 °C 的等温的氧化测试的 reactivesputtering method.The 结果的基于的合金显示出的 Ti3AI 上被扔了thatCr_( 1-x ) Al_xN 涂层能显著地在 coatings.No 的表面上由于 Al2O3+Cr2O3 混合氧化物规模的 theformation 减少合金的氧化率 thecoatings 或氧化物规模的分裂在 800 °C .Ti 发生在周期的氧化期间被观察到 diffuseinto 涂层。 | Ming ZHU Meishuan LI Shuwang DUO Yanchun ZHOU | 2007 | Journal of Materials Science & Technology2007，23，3： | 2 |
| 10 | Engineeringproperties and Microstructural Feature of the Soda Residue显示文摘 | LI Yueyong YA Shuwang ZHANG Jinyong | 1999 | Chin J Geotech Eng1999，21，1： | 1 |
| 11 | Geosynthetic tubes and geosynthetic mats: analyses and applications 显示文摘 | CHU Jian GUO Wei YAN Shuwang | 2011 | Geotechnical Engineering Journal of the SEAGS & AGSSEA2011，42，1： | 1 |
| 12 | Effect of ion im- plantation upon erosion resistance of polyimide films in space environment显示文摘 | Duo Shuwang Li Meishuan Zhou Yanchun | 2006 | Transactions of Nonferrous Metals Society of China2006，，16： | 1 |
| 13 | A Public Key Cryplosystem Based on Three New Provable Problems显示文摘 | SU Shenghui L ti Shuwang | 2012 | Theoretical Computer Science2012，，： | 1 |
| 14 | Construction of an offshore dike using slurry filled geotextile mats 显示文摘 | YAN Shuwang CHU Jian | 2010 | Geotextiles and Geomembranes2010，28，5： | 1 |
| 15 | Changes in wind speed over China during 1956–2004显示文摘 | Ying Jiang Yong Luo Zongci Zhao Shuwang Tao | 2010 | Theoretical and Applied Climatology2010，，3： | 1 |
| 16 | Comparison of photocatalytic performance of anatase TiO 2 prepared by low and high temperature route显示文摘 | Changyuan Hu Shuwang Duo Tingzhi Liu Junhuai Xiang Mingsheng Li | 2010 | Applied Surface Science2010，，8： | 1 |
| 17 | Changes in wind speed over China during 1956–2004显示文摘 | Ying Jiang Yong Luo Zongci Zhao Shuwang Tao | 2010 | Theoretical and Applied Climatology (-)2010，，3： | 1 |
| 18 | Geosynthetic mattress: analytical solution and verification 显示文摘 | GUO Wei CHU Jian YAN Shuwang | 2013 | Geotextiles and Geomembranes2013，37，： | 1 |
| 19 | Changes in wind speed over China during 1956–2004显示文摘 | Ying Jiang Yong Luo Zongci Zhao Shuwang Tao | 2010 | Theoretical and Applied Climatology (-)2010，，3： | 1 |
| 20 | Improvement of the method for marine pipeline upheaval analysis under thermal stress显示文摘 | Liu Run Yan Shuwang Sun Guomin | 2005 | Journal of Tianjin University2005，38，2： | 1 |
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