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| 1 | Bone biomaterials and interactions with stem cells显示文摘Bone biomaterials play a vital role in bone repair by providing the necessary substrate for cell adhesion,proliferation, and differentiation and by modulating cell activity and function. In past decades, extensive efforts have been devoted to developing bone biomaterials with a focus on the following issues:(1)developing ideal biomaterials with a combination of suitable biological and mechanical properties;(2)constructing a cell microenvironment with pores ranging in size from nanoscale to submicro-and microscale;and(3) inducing the oriented differentiation of stem cells for artificial-to-biological transformation. Here we present a comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells. Typical bone biomaterials that have been developed, including bioactive ceramics, biodegradable polymers, and biodegradable metals, are reviewed, with an emphasis on their characteristics and applications. The necessary porous structure of bone biomaterials for the cell microenvironment is discussed,along with the corresponding fabrication methods. Additionally, the promising seed stem cells for bone repair are summarized, and their interaction mechanisms with bone biomaterials are discussed in detail.Special attention has been paid to the signaling pathways involved in the focal adhesion and osteogenic differentiation of stem cells on bone biomaterials. Finally, achievements regarding bone biomaterials are summarized, and future research directions are proposed. | Chengde Gao Shuping Peng Pei Feng Cijun Shuai | 2017 | Bone Research2017，5，4： | 17 |
| 2 | Fuzzy Control of LED Tunnel Lighting and Energy Conservation显示文摘Current highway tunnel lighting control systems are often manually controlled,resulting in significant energy waste.This article designs a fuzzy control algorithm for tunnel lighting energy control systems.The system uses LED (Light Emitting Diode) lighting,so the fuzzy control algorithm is designed for LED lights.The traffic and the natural illumination level are used as parameters in the intelligent lighting control algorithm.This system has been deployed in the Lengshui tunnel on the 49th provincial highway of Zhejiang province and operated for more than six months.The performance results show that the energy conservation system provides sufficient lighting levels for traffic safety with significant energy conservation. | Hong Zeng Jian Qiu Xingfa Shen Guojun Dai Peng Liu Shuping Le | 2011 | Tsinghua Science and Technology2011，16，6： | 17 |
| 3 | Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity显示文摘The incorporation of hydroxyapatite(HAP)into poly-L-lactic acid(PLLA)matrix serving as bone scaffold is expected to exhibit bioactivity and osteoconductivity to those of the living bone.While too low degradation rate of HAP/PLLA scaffold hinders the activity because the embedded HAP in the PLLA matrix is difficult to contact and exchange ions with body fluid.In this study,biodegradable polymer poly(glycolic acid)(PGA)was blended into the HAP/PLLA scaffold fabricated by laser 3D printing to accelerate the degradation.The results indicated that the incorporation of PGA enhanced the degradation rate of scaffold as indicated by the weight loss increasing from 3.3%to 25.0%after immersion for 28 days,owing to the degradation of high hydrophilic PGA and the subsequent accelerated hydrolysis of PLLA chains.Moreover,a lot of pores produced by the degradation of the scaffold promoted the exposure of HAP from the matrix,which not only activated the deposition of bone like apatite on scaffold but also accelerated apatite growth.Cytocompatibility tests exhibited a good osteoblast adhesion,spreading and proliferation,suggesting the scaffold provided a suitable environment for cell cultivation.Furthermore,the scaffold displayed excellent bone defect repair capacity with the formation of abundant new bone tissue and blood vessel tissue,and both ends of defect region were bridged after 8 weeks of implantation. | Cijun Shuai Wenjing Yang Pei Feng Shuping Peng Hao Pan | 2021 | Bioactive Materials2021，6，2： | 8 |
| 4 | Reliability and validity of the Chinese version of CAHS among renal transplant recipients显示文摘Purpose:The purpose of this study was to assess the applicability of the Chinese version of Cognitive Appraisal of Health Scale(CAHS)for renal transplant recipients,and to make a preliminary evaluation of its reliability and validity.Methods:A total of 147 renal transplant recipients who attended a transplant follow-up clinic in a Level 3,Grade A hospital in Beijing were asked to complete the Chinese version of CAHS.Following completion the reliability and validity of the scale were tested.Results:The Cronbach alpha coefficient of Chinese version of CAHS among subscales of threat,harm,challenge and benign-irrelevant were 0.857,0.806,0.680,0.100 respectively;and the test-retest reliability coefficient were 0.791,0.601,0.624,0.470(p<0.01).Spearman correlation was used to test the four subscales'correlation between the item score and the total score,in which threat was 0.598e0.748,challenge was 0.517e0.651,harm was 0.528 e0.735 and benign-irrelevant was 0.507e0.651.These correlations were all statistically significant.The four common factors were extracted using factor analysis.The four factors accounted for 50.356%of the total variance.The SF-36 Physical Component Summary(PCS)and Mental Component Summary(MCS)scores were correlated with each subscale score in CAHS.Threat was weakly correlated to PCS,and was moderately correlated to MCS;harm was moderately correlated to both PCS and MCS;challenge was weakly correlated to both PCS and MCS and benign-irrelevant did not correlate with neither PCS nor MCS.The Chinese version of CAHS has been shown to have good discriminate and convergent validity.Conclusion:The Chinese version of the CAHS was supported to be applicable and to provide measurable performance in renal transplant recipients,thus it can be utilized with renal transplant recipients in China. | Shuping Zhang Yabin Shang Xiao Peng Hui Xie Hongxia Liu | 2015 | International Journal of Nursing Sciences2015，2，3： | 4 |
| 5 | Nano-SiC reinforced Zn biocomposites prepared via laser melting:Microstructure,mechanical properties and biodegradability显示文摘Zn has been regarded as new kind of potential implant biomaterials due to the desirable biodegradability and good biocompatibility,but the low strength and ductility limit its application in bone repairs.In the present study,nano-SiC was incorporated into Zn matrix via laser melting,aiming to improve the mechanical performance.The microstructure analysis showed that nano-SiC distributed along Zn grain boundaries.During the laser rapid solidification,nano-SiC particles acted as the sites for heterogeneous nucleation,which resulted in the reduction of Zn grain size from 250μm to 15μm with 2 wt%SiC(Zn-2 SiC).Meanwhile,nano-SiC acted as a reinforcer by virtue of Orowan strengthening and dispersion strengthening.As a consequence,the nanocomposites showed maximal compressive yield strength(121.8±5.3 MPa)and high microhardness(72.24±3.01 HV),which were increased by 441%and 78%,respectively,compared with pure Zn.Moreover,fracture analysis indicated a more ductile fracture of the nanocomposites after the incorporation of nano-SiC In addition,the nanocomposites presented favorable biocompatibility and accelerated degradation caused by intergranular corrosion.These findings suggested that the nano-SiC reinforced Zn biocomposites may be the potential candidates for orthopedic implants. | Chengde Gao Meng Yao Cijun Shuai Shuping Peng Youwen Deng | 2019 | Journal of Materials Science & Technology2019，35，11： | 4 |
| 6 | Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold显示文摘Zinc(Zn)possesses desirable degradability and favorable biocompatibility,thus being recognized as a promising bone implant material.Nevertheless,the insufficient mechanical performance limits its further clinical application.In this study,reduced graphene oxide(RGO)was used as reinforcement in Zn scaffold fabricated via laser additive manufacturing.Results showed that the homogeneously dispersed RGO simultaneously enhanced the strength and ductility of Zn scaffold.On one hand,the enhanced strength was ascribed to(i)the grain refinement caused by the pinning effect of RGO,(ii)the efficient load shift due to the huge specific surface area of RGO and the favorable interface bonding between RGO and Zn matrix,and(iii)the Orowan strengthening by the homogeneously distributed RGO.On the other hand,the improved ductility was owing to the RGO-induced random orientation of grain with texture index reducing from 20.5 to 7.3,which activated more slip systems and provided more space to accommodate dislocation.Furthermore,the cell test confirmed that RGO promoted cell growth and differentiation.This study demonstrated the great potential of RGO in tailoring the mechanical performance and cell behavior of Zn scaffold for bone repair. | Youwen Yang Yun Cheng Shuping Peng Liang Xu Chongxian He Fangwei Qi Mingchun Zhao Cijun Shuai | 2021 | Bioactive Materials2021，6，5： | 4 |
| 7 | Physical stimulations and their osteogenesis-inducing mechanisms显示文摘Physical stimulations such as magnetic,electric and mechanical stimulation could enhance cell activity and promote bone formation in bone repair process via activating signal pathways,modulating ion channels,regulating bonerelated gene expressions,etc.In this paper,bioeffects of physical stimulations on cell activity,tissue growth and bone healing were systematically summarized,which especially focused on their osteogenesis-inducing mechanisms.Detailedly,magnetic stimulation could produce Hall effect which improved the permeability of cell membrane and promoted the migration of ions,especially accelerating the extracellular calcium ions to pass through cell membrane.Electric stimulation could induce inverse piezoelectric effect which generated electric signals,accordingly up-regulating intracellular calcium levels and growth factor synthesis.And mechanical stimulation could produce mechanical signals which were converted into corresponding biochemical signals,thus activating various signaling pathways on cell membrane and inducing a series of gene expressions.Besides,bioeffects of physical stimulations combined with bone scaffolds which fabricated using 3D printing technology on bone cells were discussed.The equipments of physical stimulation system were described.The opportunities and challenges of physical stimulations were also presented from the perspective of bone repair. | Cijun Shuai Wenjing Yang Shuping Peng Chengde Gao Wang Guo Yuxiao Lai Pei Feng | 2018 | International Journal of Bioprinting2018，4，2： | 3 |
| 8 | Dual alloying improves the corrosion resistance of biodegradable Mg alloys prepared by selective laser melting显示文摘Mg alloys have been regarded as revolutionary metallic biomaterials for biodegradable bone implants,but their applications are mainly blocked by the too rapid degradation in physiological environment.This study explores the dual alloying effects of Mn and/or Sn on the performance of Mg alloys prepared by selective laser melting.The observed microstructure indicated remarkable refinement of both the grains and intermetallic phases in the Mn-and/or Sn-containing alloys during the rapid solidification process.Moreover,approximately a half decrease in corrosion rate was observed for AZ61-0.4Mn-0.8Sn alloy with respect to AZ61 alloy.The improved corrosion behavior was primarily due to the enhanced protective effects of surface layers,in which Mn-and/or Sn-rich phases acted as a helpful barrier against medium penetration and thereby alleviated the current exchange with the matrix.In addition,the solute Mn and/or Sn positively shifted the corrosion potential,which also brought about a better corrosion resistance.Furthermore,the strength and hardness of the alloys were also effectively improved and comparable to those of cortical bone.This could be ascribed to the dissolved Mn and/or Sn atoms and the finely dispersed intermetallic phases,which might cause lattice distortion and precipitation hardening.Besides,the Mn-and/or Sn-containing alloys showed good cytocompatibility as indicated by the normal morphology and increased viability of MG-63 cells.These findings suggest that the developed AZ61-Mn-Sn alloy is a promising candidate for biodegradable bone implants. | Chengde Gao Sheng Li Long Liu Shizhen Bin Youwen Yang Shuping Peng Cijun Shuai | 2021 | Journal of Magnesium and Alloys2021，9，1： | 3 |
| 9 | Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method显示文摘 | Peng Jiang Weixing Dai Shikai Yan Zhongliang Chen Ruilin Xu Jianmi Ding Li Xiang Shuping Wang Runhui Liu Weidong Zhang | 2011 | Journal of Ethnopharmacology2011，，2： | 2 |
| 10 | A bifunctional bone scaffold combines osteogenesis and antibacterial activity via in situ grown hydroxyapatite and silver nanoparticles显示文摘Hydroxyapatite(HA)nanoparticles and silver(Ag)nanoparticles are expected to enable desirable bioactivity and antibac-terial properties on biopolymer scaffolds.Nevertheless,interfacial adhesion between HA/Ag and the biopolymer is poor due to the large physicochemical differences between these components.In this study,poly L-lactic acid(PLLA)powder was first surface-modified with bioactive polydopamine(PDA)in an alkaline environment.Next,HA and Ag nanoparticles were grown in situ on the PDA-coated PLLA powder,which was then adhered to the porous bone scaffold using a selective laser-sintering process.Results showed that HA and Ag nanoparticles were homogenously distributed in the matrix,with enhanced mechanical properties.Simulated body fluid bioactivity tests showed that the in situ grown HA-endowed scaffold shows excellent bioactivity.In vitro tests confirmed that the scaffold exhibits favorable biocompatibility with human umbilical cord mesenchymal stem cells,as well as strong antibacterial activity against Gram-negative Escherichia coli.Furthermore,in vivo assays indicated that the scaffold promoted bone generation,with a new bone area fraction of 71.8%after 8 weeks’implantation,without inflammation. | Youwen Yang Yun Cheng Fang Deng Lida Shen Zhenyu Zhao Shuping Peng Cijun Shuai | 2021 | Bio-Design and Manufacturing2021，4，3： | 2 |
| 11 | Plasma pharmacochemistry based approach to screening potential bioactive components in Huang-Lian-Jie-Du-Tang using high performance liquid chromatography coupled with mass spectrometric detection显示文摘 | Yaohua Hu Peng Jiang Shuping Wang Shikai Yan Li Xiang Weidong Zhang Runhui Liu | 2011 | Journal of Ethnopharmacology2011，，2： | 1 |
| 12 | Laser additive manufacturing of zinc:formation quality,texture,and cell behavior显示文摘Laser powder bed fusion(LPBF)makes it possible for biodegradable zinc(Zn)to be used to produce customized orthopedic implants.In this research,we investigate the impact of laser power and scanning speed on the development of surface quality,relative densification,and texture during LPBF of Zn implants.Increasing laser power was able to decrease melt viscosity and surface tension,which improved the metallurgical bonding between adjacent tracks.Uneven and twisted tracks also became continuous and straight.Scanning speed could controlmolten-pool temperature to restrain grain natural orientation,achieving various crystal orientations and a weakened texture.Importantly,it further avoided the thermal expansion and contraction caused by excessive energy storage and accumulation in the matrix,thus reducing the generation of high-dislocation density.As a result,by selecting a reasonable laser power and scanning speed,the LPBF parts exhibited a flat surface morphology and a high density over 99.5%.Their average hardness,mechanical strength,and elongation reached 50.2 HV,127.8 MPa,and 7.6%,respectively.Additionally,the parts displayed a moderate degradation rate and excellent osteogenic properties.All these results provide a basis for selecting process parameters to optimize the comprehensive properties of LPBF-processed Zn parts for biodegradable applications. | Mingli Yang Liuyimei Yang Shuping Peng Fang Deng Yageng Li Youwen Yang Cijun Shuai | 2023 | Bio-Design and Manufacturing2023，6，2： | 1 |
| 13 | Role of optical network virtualization in cloud eomputing显示文摘 | Shuping Peng Nejabati R Simeonidou D | 2013 | Optical Communications and Networking2013，10，： | 1 |
| 14 | Additive manufacturing of bone scaffolds显示文摘Additive manufacturing(AM)can obtain not only customized external shape but also porous internal structure for scaffolds,both of which are of great importance for repairing large segmental bone defects.The scaffold fabrication process generally involves scaffold design,AM,and post-treatments.Thus,this article firstly reviews the state-of-the-art of scaffold design,including computer-aided design,reverse modeling,topology optimization,and mathematical modeling.In addition,the current characteristics of several typical AM techniques,including selective laser sintering,fused deposition modeling(FDM),and electron beam melting(EBM),especially their advantages and limitations are presented.In particular,selective laser sintering is able to obtain scaffolds with nanoscale grains,due to its high heating rate and a short holding time.However,this character usually results in insufficient densification.FDM can fabricate scaffolds with a relative high accuracy of pore structure but with a relative low mechanical strength.EBM with a high beam-material coupling efficiency can process high melting point metals,but it exhibits a low-resolution and poor surface quality.Furthermore,the common post-treatments,with main focus on heat and surface treatments,which are applied to improve the comprehensive performance are also discussed.Finally,this review also discusses the future directions for AM scaffolds for bone tissue engineering. | Youwen Yang Guoyong Wang Huixin Liang Chengde Gao Shuping Peng Lida Shen Cijun Shuai | 2019 | International Journal of Bioprinting2019，5，1： | 1 |
| 15 | Software-Defined Optical Data Centre Networks显示文摘Based on the analysis of data centre(DC) traffic pattern, we introduced a holistic software-defined optical DC solution. Architecture-on-Demand based hybrid optical switched(OPS/OCS) data centre network(DCN) fabric is introduced, which is able to realise different inter-and intra-cluster configurations and dynamically support diverse traffic in the DC. The optical DCN is controlled and managed by a software-defined networking(SDN) enabled control plane to achieve high programmability. Moreover, virtual data centre(VDC) composition is developed as an application of such softwaredefined optical DC to create VDC slices for different tenants. | PENG Shuping GUO Bingli SHU Yi George Zervas Reza Nejabati Dimitra Simeonidou | 2015 | China Communications2015，12，8： | 1 |
| 16 | In-situ deposition of apatite layer to protect Mg-based composite fabricated via laser additive manufacturing显示文摘Biodegradable magnesium(Mg) and its alloy show huge potential as temporary bone substitute due to the favorable biocompatibility and mechanical compatibility. However, one issue deserves attention is the too fast degradation. In this work, mesoporous bioglass(MBG)with high pore volume(0.59 cc/g) and huge specific surface area(110.78 m^(2)/g) was synthesized using improved sol-gel method, and introduced into Mg-based composite via laser additive manufacturing. Immersion tests showed that the incorporated MBG served as powerful adsorption sites, which promoted the in-situ deposition of apatite by successively adsorbing Ca2+and HPO42-. Such dense apatite film acted as an efficient protection layer and enhanced the corrosion resistance of Mg matrix, which was proved by the electrochemical impedance spectroscopy measurements. Thereby, Mg based composite showed a significantly decreased degradation rate of 0.31 mm/year. Furthermore,MBG also improved the mechanical properties as well as cell behavior. This work highlighted the advantages of MBG in the fabrication of Mg-based implant with enhanced overall performance for orthopedic application. | Youwen Yang Changfu Lu Lida Shen Zhenyu Zhao Shuping Peng Cijun Shuai | 2023 | Journal of Magnesium and Alloys2023，11，2： | 1 |
| 17 | Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors显示文摘Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver drugs.However,the severe systemic inflammatory response triggered by OMVs upon intravenous(i.v.)injection has limited their application.Here,we developed a safe and effective strategy by conjugating doxorubicin-loaded serum albumin(SA-DOX,AD)onto the surface of OMVs using a matrix metalloproteinase(MMP)-cleavable peptide linker(cL).This approach enabled the dynamic shielding of OMVs to reduce the systemic side effects while simultaneously enhancing the anti-tumor effects through chemo-immunotherapy.Specifically,the resulting OMV-cL-AD formulation exhibited significantly enhanced accumulation at the tumor site after i.v.administration,facilitated by the SA decoration on the OMVs surface.Subsequently,the shield on the OMV-cL-AD was cleaved by the over-expressed MMP in the TME,leading to the release of both OMVs and AD.This process provided OMV-induced immunotherapy and DOX-induced chemotherapy,resulting in synergistic tumor inhibition.In conclusion,our work demonstrated the potential of OMV-cL-AD as an effective immunochemotherapy strategy that can prolong the survival time of mice without inducing side effects. | Shuping Li Xin Li Jiaqi Meng Weier Bao Shuang Wang Peng Ye Xiao-Dong Gao Wei Wei | 2024 | Nano Research2024，17，2： | 1 |
| 18 | The ABI2-dependent abscisic acid signalling controls HrpN-induced drought tolerance in Arabidopsis显示文摘 | Hong-Ping Dong Haiqin Yu Zhilong Bao Xiaojing Guo Jianling Peng Zhen Yao Guangyong Chen Shuping Qu Hansong Dong | 2005 | Planta2005，，3： | 1 |
| 19 | PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients显示文摘 | Guoping Peng Shuping Li Wei Wu Xufei Tan Yiqiong Chen Zhi Chen | 2007 | Molecular Immunology2007，，4： | 1 |
| 20 | A multi-scale porous scaffold fabricated by a combined additive manufacturing and chemical etching process for bone tissue engineering显示文摘It is critical to develop a fabrication technology for precisely controlling an interconnected porous structure of scaffolds to mimic the native bone microenvironment.In this work,a novel combined process of additive manufacturing(AM)and chemical etching was developed to fabricate graphene oxide/poly(L-lactic acid)(GO/PLLA)scaffolds with multiscale porous structure.Specially,AM was used to fabricate an interconnected porous network with pore sizes of hundreds of microns.And the chemical etching in sodium hydroxide solution constructed pores with several microns or even smaller on scaffolds surface.The degradation period of the scaffolds was adjustable via controlling the size and quantity of pores.Moreover,the scaffolds exhibited surprising bioactivity after chemical etching,which was ascribed to the formed polar groups on scaffolds surfaces.Furthermore,GO improved the mechanical strength of the scaffolds. | Cijun Shuai Youwen Yang Pei Feng Shuping Peng Wang Guo Anjie Min Chengde Gao | 2018 | International Journal of Bioprinting2018，4，2： | 1 |
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