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| 1 | MiR-147b inhibits cell viability and promotes apoptosis of rat H9c2 cardiomyocytes via down-regulating KLF13 expression显示文摘最近, microRNAs (miRNAs ) 被显示了在心失败的过程包含。这研究试图在老鼠 H9c2 cardiomyocytes 调查 miR-147b 的功能的角色并且探索内在的分子的机制。H9c2 房间的房间生存能力被 MTT 试金检测。房间 apoptosis 被流动 cytometry 检测。miR-147b 和 KLF13 mRNA 的表示被量的即时 PCR 检测。在 miR-147b 和 KLF13 之间的关系被双酶的记者试金验证。蛋白质层次被西方的污点分析检测。它被发现那 H 2 O 2 禁止了房间生存能力并且以一种集中依赖者方式支持了 H9c2 房间的房间 apoptosis。MiR-147b overexpression miR-147b 压制了房间生存能力并且在 H9c2 房间增加了 apoptosis,当击倒时在 H 2 O 2-treated H9c2 房间。酶记者试金并且在功能的试金显示出的 vitro,那 KLF13 是 miR-147b,和 KLF13 的一个下游的目标在 H9c2 房间的击倒的压制的房间生存能力和导致的 apoptosis。KLF13 的强制表示在 H9c2 房间在房间生存能力和 apoptosis 上恢复了 miR-147b overexpression 的效果。MiR-147b 在 apoptosis 相关的蛋白质上调制了 miR-147b overexpression 的 apoptosis 相关的蛋白质,和效果的表示层次层次被 KLF13 的强制表示在 H9c2 房间阻止。在里面 vivo 实验证明 miR-147b 是起来调整的,并且 KLF13 在从有长期的心失败的老鼠的心肌的纸巾是下面调整的。一起, miR-147b 禁止生存能力并且由在 H9c2 房间指向 KLF13 支持房间 apoptosis,它可以与心失败的致病被联系。 | Mingxia Gu Jing Wang Yi Wang Yanjuan Xu Yingqiang Zhang Weiqing Wu Shuping Liao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 6 |
| 2 | Stereo mapping of Ming Great Wall with remote sensing显示文摘Listed by UNESCO in 1987 as a World Heritage site,the world-famous Ming Great Wall stretches several thousands of kilometers across northern China,and served as a massive military defensive system which in recent times has a unique historical,artistic and scientific value.Due to historical reasons and lack of advanced technologies,construction resources and conservation status of Ming Great Wall have not been investigated in any systematic manner;indeed,the extent of the Great Wall has not even been measured.This has resulted in a shortage of reliable first-hand scientific information on actual size,spatially resource distribution and preservation status of this World Heritage site.Driven by the urgent need to establish protection,research,renovation and management of Ming Great Wall,a comprehensive investigation and spatial mapping was jointly organized and completed by the State Bureau of Survey and Mapping and State Administration of Culture Heritage.High resolution digital stereo models at 1:10000 map scale covering the whole length of the Ming Great Wall have been created by photogrammetric reconstruction using nearly ten thousand aerial images.Spatial distribution and attributes of the wall sections,trenches and various subsidiary facilities in the surroundings of the Great Wall were measured with the help of digital photogrammetry workstations and results from field studies.Reliable and precise information about the Ming Great Wall has now been obtained and documented,including surface lengths,resource distribution,and preservation status.For example,the total length of Ming Great Wall is 8851.8 km,of which 6259.6 km is of actual wall,2232.5 km of natural terrain,and 359.7 km of trenches.In category lengths,1828.8 km is constructed of stone,3411.3 km of earth,249.6 km in brick,197.5 km of cliff wall and the rest 572.4 km of other means.Such information provides the scientific basis and strong platform in helping to delineate areas needing protection,in planning conservation and renovation programs,as well as digital archiving for posterity and web-based applications for modern promotions of one of the world's great attractions,the Ming Great Wall. | CHEN Jun JIN ShuPing LIAO AnPing ZHAO YouSong ZHANG HongWei RONG DaWei YANG ZhaoJun | 2010 | Chinese Science Bulletin2010，55，21： | 1 |
| 3 | A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer显示文摘Modulating Tankyrases(TNKS),interactions with USP25 to promote TNKS degradation,rather than inhibiting their enzymatic activities,is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway.Here,we identified UAT-B,a novel neoantimycin analog isolated from Streptomyces conglobatus,as a small-molecule inhibitor of TNKS-USP25 protein-protein interaction(PPI)to overcome multi-drug resistance in colorectal cancer(CRC).The disruption of TNKS-USP25 complex formation by UAT-B led to a significant decrease in TNKS levels,triggering cell apoptosis through modulation of the Wnt/β-catenin pathway.Importantly,UAT-B successfully inhibited the CRC cells growth that harbored high TNKS levels,as demonstrated in various in vitro and in vivo studies utilizing cell line-based and patient-derived xenografts,as well as APC^(min/+)spontaneous CRC models.Collectively,these findings suggest that targeting the TNKS-USP25 PPI using a small-molecule inhibitor represents a compelling therapeutic strategy for CRC treatment,and UAT-B emerges as a promising candidate for further preclinical and clinical investigations. | Hongrui Zhu Yamin Gao Liyun Liu Mengyu Tao Xiao Lin Yijia Cheng Yaoyao Shen Haitao Xue Li Guan Huimin Zhao Li Liu Shuping Wang Fan Yang Yongjun Zhou Hongze Liao Fan Sun Houwen Lin | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 4 | Divergent Syntheses of Pyridoacridine Alkaloids via Palladium-Catalyzed Reductive Cyclization with Nitro-Biarenes显示文摘Main observation and conclusion A divergent and novel protocol for the preparation of both pyrido[2,3,4-kl]acridine and pyrido[4,3,2-kl]acridine alkaloids was developed.This method featured the remote palladium-catalyzed reductive cyclization with Mo(CO)_(6) as reductant.A wide range of substrates including three types of nitro arenes were tolerated and afforded corresponding products in good to excellent yields. | Bo Liu Shuping Wang Changhao Bian Hongze Liao Hou-Wen Lin | 2021 | Chinese Journal of Chemistry2021，39，7： | 0 |
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