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| 1 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 2 | Hyperglycemia induces protein nonenzymeatic glycosylation in brain neurons of diabetic rats at early stage显示文摘BACKGROUND: Protein nonenzymatic glycosylation is supposed to be one of mechanisms for chronic complications development in diabetes mellitus, and therefore, might play an important role in the neuronal degeneration. OBJECTIVE: To study the protein nonenzymatic glycosylation in brain neurons of diabetic rats, and to analyze the pathway of neuronal degeneration at the early stage of hyperglymecia. DESIGN: Randomized controlled animal experiment. SETTING: Department of Endocrinology, First hospital Affiliated to General Hospital of Chinese PLA and Beijing Laboratory for Brain Aging, Xuanwu Hospital Affiliated to Capital Medical University. MATERIALS: Thirty-five male Wistar rats (grade Ⅱ), aged 3 months old, and 11 male purebred Kunming mice (grade Ⅲ) without special pathogen, aged 3 months old, were provided by the Animal Room of Capital Medical University. METHODS: This experiment was carried out in the Beijing Laboratory for Brain Aging, Xuanwu Hospital Affiliated to Capital Medical University in 1998. The rats in the diabetic model group were intraperitoneally injected into 10 g/L STZ according to 60 mg/kg to establish rat models of diabetes mellitus. The blood glucose and body mass of rats in each group were determined respectively at 1, 2 and 3 months after modeling. The antibodies of advanced glycosylation end products (AGEs) of bovine serum albumin (anti-BSA) were self-prepared: ①The antigen of AGEs-BSA was prepared.②Eleven male Kuming mice (grade Ⅱ) of 3 months old without special pathogen were selected to inoculate AGEs-BSA. ③ The animals were immunized. ④Primary purification and detection of poly-antibodies of AGEs: the AGEs were performed immunohistochemical examination at 1 month after diabetic modeling by ELISA method. MAIN OUTCOME MEASURES: ① Detection results of blood glucose and body mass of rats in two groups at different time points. ② Determination of polyclonal antibody titer of AGEs-BSA. ③ Changes in immunohistochemical image of AGEs in brain tissue of rats in two groups. RESULTS: Thirteen rats in the diabetic model group and fifteen rats in the normal model group entered the stage of final analysis. ①Changes of blood glucose and body mass: At 1, 2 and 3 months after modeling, the blood glucose of rats in the diabetic model group were respectively(28.8±2.8),(23.1±5.5),(25.4± 5.1) mmol/L, which were significantly higher than those in the normal control group [(6.2±0.9),(6.1±0.8), (6.1±0.7) mmol/L,P < 0.01]; At 1, 2 and 3 months after modeling, the body mass of rats in the diabetic model group were respectively (250.1±52.2),(263.8±50.0),(261.5±42.6) g, which were significantly lower than those in the normal control group [(422.6±36.2),(462.6±39.0),(485.0±28.8) g,P < 0.01]. ②Determination of antibody titer of immune serum: The mice were treated by AGEs-BSA of different concentrations twice. After that, the titer of AGEs -BSA was determined, and the results of which indicated that a higher absorbance existed at 1∶1 000. ③Determination of antigen concentration: The final titer of antibody in the abdominal dropsy was determined, and the results of which suggested that there was a much higher absorbance in the AGEs-BSA at the concentration of 5–50 mg/L. ④Determination of antibody titer in abdominal dropsy: The antibody titer in abdominal dropsy was detected by ELISA method with antigen at 20 mg/L, which indicated that the maximum absorbance (1.265±0.039) existed at 1∶4 000, and very larger absorbance (0.982±0.067) at 1∶20 000. The polyclonal antibody of AGEs-BSA was successfully prepared. ⑤Immunohistochemical detection results: The immunohistochemical staining of AGEs showed there were positive neurons in the first month in the diabetic model group, whereas it was not significant in the normalcontrol group. The positive substances were found mainly in the cytoplasm. CONCLUSION: Hyperglycemia at the early stage of diabetes mellitus (1 month after modeling) can lead to protein nonenzymeatic glycosylation in brain neurons, and no obvious reactions mentioned above are found in the normal control group. It suggests that the degenerative changes of tissue structure of central nervous system are related with protein nonenzymeatic glycosylation caused by hyperglycemia. | Jingsheng Hu Xueyi Ma Shuli Sheng | 2007 | Neural Regeneration Research2007，2，1： | 2 |
| 3 | KLF7 promotes preadipocyte proliferation via activation of the Akt signaling pathway by Cis-regulating CDKN3显示文摘Krüppel-like transcription factor 7(KLF7)promotes preadipocyte proliferation;however,its target gene in this process has not yet been identified.Using KLF7 ChIP-seq analysis,we previously showed that a KLF7-binding peak is present upstream of the cyclin-dependent kinase inhibitor 3 gene(CDKN3)in chicken preadipocytes.In the present study,we identify CDKN3 as a target gene of KLF7 that mediates the effects of KLF7 on preadipocyte proliferation.Furthermore,5′-truncating mutation analysis shows that the minimal promoter is located between nt–160 and nt–7(relative to the translation initiation codon ATG)of CDKN3.KLF7 overexpression increases CDKN3 promoter activity in the DF-1 and immortalized chicken preadipocyte(ICP1)cell lines.Deletion of the putative binding site of KLF7 abolishes the promotive effect of KLF7 overexpression on CDKN3 promoter activity.Moreover,CDKN3 knockdown and overexpression assays reveal that CDKN3 enhances ICP1 cell proliferation.Flow cytometry analysis shows that CDKN3 accelerates the G1/S transition.Furthermore,we find that KLF7 promotes ICP1 cell proliferation via Akt phosphorylation by regulating CDKN3.Taken together,our results suggest that KLF7 promotes preadipocyte proliferation by activating the Akt signaling pathway by cis-regulating CDKN3,thus driving the G1/S transition. | Ziqiu Jia Zhao Jin Shuli Shao Hu Xu Wen Li Mahmood Khan Weiyu Wang Weiwei Zhang Yingning Sun | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 2 |
| 4 | Hydrogen sulfide acts as a regulator of flower senescence in plants显示文摘 | ZHANG Hua HU Shuli ZHANG Zejun | | 0，，03： | 1 |
| 5 | Effect of pyrimorph on soil enzymatic activities and respiration显示文摘 | Dan Xiong Zhenzhen Gao Bin Fu Hu Sun Shuli Tian Yumei Xiao Zhaohai Qin | 2013 | European Journal of Soil Biology2013，，： | 1 |
| 6 | A Deep Learning Driven Feature Based Steganalysis Approach显示文摘The goal of steganalysis is to detect whether the cover carries the secret information which is embedded by steganographic algorithms.The traditional ste-ganalysis detector is trained on the stego images created by a certain type of ste-ganographic algorithm,whose detection performance drops rapidly when it is applied to detect another type of steganographic algorithm.This phenomenon is called as steganographic algorithm mismatch in steganalysis.To resolve this pro-blem,we propose a deep learning driven feature-based approach.An advanced steganalysis neural network is used to extract steganographic features,different pairs of training images embedded with steganographic algorithms can obtain diverse features of each algorithm.Then a multi-classifier implemented as lightgbm is used to predict the matching algorithm.Experimental results on four types of JPEG steganographic algorithms prove that the proposed method can improve the detection accuracy in the scenario of steganographic algorithm mismatch. | Yuchen Li Baohong Ling Donghui Hu Shuli Zheng Guoan Zhang | 2023 | Intelligent Automation & Soft Computing2023，37，8： | 0 |
| 7 | An improved master-apprentice evolutionary algorithm for minimum independent dominating set problem显示文摘The minimum independent dominance set(MIDS)problem is an important version of the dominating set with some other applications.In this work,we present an improved master-apprentice evolutionary algorithm for solving the MIDS problem based on a path-breaking strategy called MAE-PB.The proposed MAE-PB algorithm combines a construction function for the initial solution generation and candidate solution restarting.It is a multiple neighborhood-based local search algorithm that improves the quality of the solution using a path-breaking strategy for solution recombination based on master and apprentice solutions and a perturbation strategy for disturbing the solution when the algorithm cannot improve the solution quality within a certain number of steps.We show the competitiveness of the MAE-PB algorithm by presenting the computational results on classical benchmarks from the literature and a suite of massive graphs from real-world applications.The results show that the MAE-PB algorithm achieves high performance.In particular,for the classical benchmarks,the MAE-PB algorithm obtains the best-known results for seven instances,whereas for several massive graphs,it improves the best-known results for 62 instances.We investigate the proposed key ingredients to determine their impact on the performance of the proposed algorithm. | Shiwei PAN Yiming MA Yiyuan WANG Zhiguo ZHOU Jinchao JI Minghao YIN Shuli HU | 2023 | Frontiers of Computer Science2023，17，4： | 0 |
| 8 | Expert consensus on difficulty assessment of endodontic therapy显示文摘Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics. | Dingming Huang Xiaoyan Wang Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Xinmei Chen Jiyao Li Ling Ye Lei Cheng Xin Xu Tao Hu Hongkun Wu Bin Guo Qin Su Zhi Chen Lihong Qiu Wenxia Chen Xi Wei Zhengwei Huang Jinhua Yu Zhengmei Lin Qi Zhang Deqin Yang Jin Zhao Shuang Pan Jian Yang Jiayuan Wu Yihuai Pan Xiaoli Xie Shuli Deng Xiaojing Huang Lan Zhang Lin Yue Xuedong Zhou | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 9 | Multi-Layer Deep Sparse Representation for Biological Slice Image Inpainting显示文摘Biological slices are an effective tool for studying the physiological structure and evolutionmechanism of biological systems.However,due to the complexity of preparation technology and the presence of many uncontrollable factors during the preparation processing,leads to problems such as difficulty in preparing slice images and breakage of slice images.Therefore,we proposed a biological slice image small-scale corruption inpainting algorithm with interpretability based on multi-layer deep sparse representation,achieving the high-fidelity reconstruction of slice images.We further discussed the relationship between deep convolutional neural networks and sparse representation,ensuring the high-fidelity characteristic of the algorithm first.A novel deep wavelet dictionary is proposed that can better obtain image prior and possess learnable feature.And multi-layer deep sparse representation is used to implement dictionary learning,acquiring better signal expression.Compared with methods such as NLABH,Shearlet,Partial Differential Equation(PDE),K-Singular Value Decomposition(K-SVD),Convolutional Sparse Coding,and Deep Image Prior,the proposed algorithm has better subjective reconstruction and objective evaluation with small-scale image data,which realized high-fidelity inpainting,under the condition of small-scale image data.And theOn2-level time complexitymakes the proposed algorithm practical.The proposed algorithm can be effectively extended to other cross-sectional image inpainting problems,such as magnetic resonance images,and computed tomography images. | Haitao Hu Hongmei Ma Shuli Mei | 2023 | Computers, Materials & Continua2023，76，9： | 0 |
| 10 | 凋落物年龄和氮、磷添加交互作用对杉木林土壤N_(2)O排放的影响显示文摘氧化亚氮(N_(2)O)是一种重要的温室气体,增温潜势较大,其浓度增加影响全球气候变化。由于凋落物分解影响碳和养分循环,土壤N_(2)O排放受凋落物分解作用,而凋落物年龄和氮、磷添加影响凋落物分解,潜在影响土壤N_(2)O的排放。然而,凋落物年龄和养分添加对土壤N_(2)O排放的交互作用及其机制目前还没有报道,这限制了凋落物分解对N_(2)O排放的影响评价。本研究以杉木(Cunninghamia lanceolata)不同年龄凋落物为研究对象,通过氮、磷添加处理,研究了养分和凋落物年龄对N_(2)O排放的影响及其机制。研究结果显示,幼龄凋落物主要通过调节碳氮比来影响N_(2)O排放。氮添加主要通过调节凋落物碳氮比、土壤pH以及与N_(2)O产生相关的微生物功能基因所编码的土壤酶活性来影响N_(2)O排放,整体上促进N_(2)O排放。磷添加显著降低凋落物碳氮比,进而作用于N_(2)O排放,该途径促进N_(2)O排放。同时,磷添加提高土壤有效磷水平,潜在降低N_(2)O排放,整体上降低土壤N_(2)O排放。凋落物年龄和养分添加交互作用于土壤N_(2)O排放。因此,在森林经营管理中,评价不同管理措施,尤其是间伐和选择性砍伐等导致不同凋落物输入的管理活动对土壤N_(2)O排放的影响时,应同时考虑养分输入和凋落物年龄的潜在影响。 | Shuli Wang Xi Yuan Ling Zhang Fusheng Chen Xiangmin Fang Xiaojun Liu Bangliang Deng Nasir Shad Wenyuan Zhang Xiaofei Hu Xiaomin Guo Evan Siemann | 2022 | Journal of Plant Ecology2022，15，4： | 0 |
| 11 | PU.1 interacts with KLF7 to suppress differentiation and promote proliferation in chicken preadipocytes显示文摘Krüppel-like factor 7(KLF7)is a negative regulator of preadipocyte differentiation.Our previous KLF7 ChIP-seq analysis showed that the binding motif of PU.1 was found among the KLF7 binding peaks,indicating that an interaction between KLF7 and PU.1 at preadipocyte gene promoters and other regulatory elements might be common.Here,Co-IP and FRET assays are used to confirm that PU.1 can directly bind to KLF7 and enhance the transcription activity of cyclin-dependent kinase inhibitor 3(CDKN3),which is a downstream target gene of KLF7.We show that the PU.1 expression level is decreased during preadipocyte differentiation.Furthermore,PU.1 overexpression and knockdown experiments reveal that PU.1 negatively regulates chicken preadipocyte differentiation,as evidenced by appropriate changes in lipid droplet accumulation and altered expressions of PPARγ,FAS,and PLIN.In addition,PU.1 overexpression promotes preadipocyte proliferation,while knockdown of PU.1 inhibits preadipocyte proliferation.We further demonstrate that PU.1 inhibits differentiation and promotes proliferation in preadipocytes,in part by directly interacting with KLF7. | Ming Tan Hu Xu Jinwei Li Ziqiu Jia Xin Zhang Shuli Shao Weiwei Zhang Weiyu Wang Yingning Sun | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
| 12 | Petrogenesis and Tectonic Implications of the Paleoproterozoic A-Type Granites in the Xiong’ershan Area along the Southern Margin of the North China Craton显示文摘Paleoproterozoic A-type granites are widely distributed in the southern margin of the North China Craton(SNCC),providing important information for understanding the Paleoproterozoic tectonic regimes in this area.This paper reports newly obtained whole-rock compositions and zircon U-Pb ages for the Tieluping syenogranite porphyry(TLP)and Huoshenmiao alkali granite porphyry(HSM)in the SNCC.Zircons from the TLP and HSM have U-Pb ages of 1805±12 and 1792±14 Ma,respectively.These ages are taken to date the emplacement of these intrusions.They had high total alkali contents(K_(2)O+Na_(2)O>7.13 wt.%),with high 10000×Ga/Al ratios(3.06–3.41)and Zr+Y+Nb+Ce values(709 ppm–910 ppm)as well as high zircon saturation temperatures(864–970℃),indicative of A-type granite affinities.High Y/Nb(1.75–3.32),Ce/Nb(7.72–9.72),and Yb/Ta(2.89–5.60)ratios suggested that TLP and HSM belonged to the A2-type granite.The negative whole rockε_(Nd)(t)values(−8.4 to−6.6)and negative zirconε_(Hf)(t)values(−15.9 to−6.3)confirmed that TLP and HSM were likely generated by the partial melting of an ancient continental crust.TheεHf(t)(−7.4 to+4.0)values of inherited zircons in the TLP suggested that they were derived from the partial melting of Archean basement rocks.Considering the geochemical similarity of the 1.80 Ga A-type granitoids in the SNCC,we propose that the TLP and HSM were formed in a post-collisional regime that was likely associated with the break-off of the Paleoproterozoic subducted slab.Upwelling of the asthenosphere provided huge heat to generate the regional 1.80 Ga A-type granite in the SNCC. | Jinhong Xu Yuping Jiang Shuli Hu Zhengwei Zhang Chengquan Wu Chaofei Zheng Xiyao Li Ziru Jin Sensen Zhang Yatao Zhou | 2024 | Journal of Earth Science2024，35，2： | 0 |
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