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| 1 | Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium显示文摘Although mesenchymal stem cell-derived exosomes(MSC-exos)have been shown to have therapeutic effects in experimental periodontitis,their drawbacks,such as low yield and limited efficacy,have hampered their clinical application.These drawbacks can be largely reduced by replacing the traditional 2D culture system with a 3D system.However,the potential function of MSC-exos produced by 3D culture(3D-exos)in periodontitis remains elusive.This study showed that compared with MSC-exos generated via 2D culture(2D-exos),3D-exos showed enhanced anti-inflammatory effects in a ligature-induced model of periodontitis by restoring the reactive T helper 17(Th17)cell/Treg balance in inflamed periodontal tissues.Mechanistically,3D-exos exhibited greater enrichment of miR-1246,which can suppress the expression of Nfat5,a key factor that mediates Th17 cell polarization in a sequence-dependent manner.Furthermore,we found that recovery of the Th17 cell/Treg balance in the inflamed periodontium by the local injection of 3D-exos attenuated experimental colitis.Our study not only showed that by restoring the Th17 cell/Treg balance through the miR-1246/Nfat5 axis,the 3D culture system improved the function of MSC-exos in the treatment of periodontitis,but also it provided a basis for treating inflammatory bowel disease(IBD)by restoring immune responses in the inflamed periodontium. | Yong Zhang Jiayao Chen Haijun Fu Shuhong Kuang Feng He Min Zhang Zongshan Shen Wei Qin Zhengmei Lin Shuheng Huang | 2021 | International Journal of Oral Science2021，13，4： | 4 |
| 2 | Resources Conditions of Coalbed Methane Districts in China显示文摘The China National Administration of Coal Geology accomplished an assessment of coalbed methaneresources of China in 1988. The total amount of coalbed methane resources in China is 14336.944 billion m , occurring in recoverable coal seams and beneath weathering zones, with coalbed methane content equal to or higher than 4 m3 per ton and buried depths smaller than 2000 m, among which there are 967.51 billion m of predicted reserves and 13369.434 billion m of future reserves. The resources in coal reservoirs with methane content of more than 8 m per ton are 12444.087 billion m , and those with methane content between 4 to 8 m per ton are 1892.856 billion m . There are 35 districts in which the resources abundance is higher than 150 million m3 /km2 , 49 districts with the abundance between 50 million and 150 million m 3/km2 , and 31 districts with the abundance less than 50 million m3 /km2 . There is 9256.078 billion m3 of methane occurring in coal seams with buried depths less than 1500 m, and 5080.866 | TANG Shuheng LIN Dayang | 2000 | Acta Geologica Sinica(English Edition)2000，74，3： | 4 |
| 3 | Evalutionary Comution Infinalcial Engineering: A Road Map of GAs and GP 显示文摘 | Chen Shuheng Lin | 1998 | Financial Engineering News1998，4，2： | 1 |
| 4 | Long-term change in low-cloud cover in Southeast China during cold seasons显示文摘中国东南地区在冬春冷季节盛行低云,对局地能量平衡和水文循环有重要的作用.本研究使用多套数据和数值模拟结果,分析这一地区冷季节内低云云量在1980年至2017年的长期变化.结果表明,低云云量经历了先下降后上升的趋势变化,转折点出现在2008年左右.局地水汽通量输送在影响低云云量的变化中起着至关重要的作用,其在冬季和春季分别受到哈德莱环流和沃克环流的影响.CMIP6中的气候模式对水汽通量输送的模拟能力欠佳,影响了对低云云量的模拟结果. | Zhe Chen Minghuai Wang Haipeng Zhang Shuheng Lin Zhun Guo Yiquan Jiang Chen Zhou | 2022 | Atmospheric and Oceanic Science Letters2022，15，6： | 1 |
| 5 | Exploration of the shared gene signatures and molecular mechanisms between periodontitis and inflammatory bowel disease:evidence from transcriptome data显示文摘Background:Periodontitis disease(PD)is associated with a systemic disorder of inflammatory bowel disease(IBD).The immune response is the common feature of the two conditions,but the more precise mechanisms remain unclear.Methods:Differential expressed genes(DEGs)analysis and weighted gene co-expression network analysis(WGCNA)were performed on PD and Crohn’s disease(CD)data sets to identify crosstalk genes linking the two diseases.The proportions of infiltrating immune cells were calculated by using Single-sample Gene Set Enrichment Analysis.In addition,a data set of isolated neutrophils from the circulation was performed via WGCNA to obtain PD-related key modules.Then,single-cell gene set enrichment scores were computed for the key module and grouped neutrophils according to score order in the IBD scRNA-seq data set.Single-cell gene enrichment analysis was used to further explore the biological process of the neutrophils.Results:A total of 13 crosstalk genes(IL1B,CSF3,CXCL1,CXCL6,FPR1,FCGR3B,SELE,MMP7,PROK2,SRGN,FCN1,TDO2 and CYP24A1)were identified via DEGs analysis and WGCNA by combining PD and CD data sets.The enrichment analysis showed that these genes were involved in interleukin-10 signaling and inflammatory response.The immune infiltration analysis showed a significant difference in the proportion of neutrophils in PD and CD compared with healthy patients.Neutrophils were scored based on the expression of a periodontitis-related gene set in the scRNA-seq data set of IBD.The enrichment analysis demonstrated that inflammatory response,TNFa signaling via NF-jB and interferon-gamma response were upregulated in the high-score group,which expressed more pro-inflammatory cytokines and chemokines compared with the low-score group.Conclusions:This study reveals a previously unrecognized mechanism linking periodontitis and IBD through crosstalk genes and neutrophils,which provides a theoretical framework for future research. | Chi Zhan Zhaocai Zhou Yaxian Huang Shuheng Huang Zhengmei Lin FengHe Zhi Song | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 6 | Characteristics of Coalbed Methane Resources of China显示文摘The paper deals with the coalbed methane gas-bearing characteristics such as the gas content, theoretical gas saturation, gas concentration and abundance, as well as coal reservoir characteristics such as the adsorption, desorption and permeability of China’s coal reservoirs. The paper also introduces the resources of coalbed methane with a gas content ≥4 m3/t and their distribution in China. | LIN Dayang YE Jianping QIN Yong TANG Shuheng | 2000 | Acta Geologica Sinica(English Edition)2000，74，3： | 0 |
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