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| 1 | Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment显示文摘To evaluate the differences in outcomes of treatment with denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients with primary osteoporosis. Patients were split into a denosumab monotherapy group(18 cases) or a denosumab plus vitamin D supplementation group(combination group; 23 cases). We measured serum bone alkaline phosphatase(BAP), tartrate-resistant acid phosphatase(TRACP)-5 b and urinary N-terminal telopeptide of type-I collagen(NTX) at baseline, 1 week, as well as at 1 month and 2, 4, 8 and 12 months. We also measured bone mineral density(BMD) of L1–4 lumbar vertebrae(L)-BMD and bilateral hips(H)-BMD at baseline and at 4, 8 and 12 months. There was no significant difference in patient background. TRACP-5 b and urinary NTX were significantly suppressed in both groups from 1 week to 12 months(except at 12 months for NTX). In the combination group, TRACP-5 b was significantly decreased compared with the denosumab monotherapy group at 2 and 4 months(P < 0.05).BAP was significantly suppressed in both groups at 2–12 months. L-BMD significantly increased at 8 and12 months(8.9%) in the combination group and at 4, 8 and 12 months(6.0%) in the denosumab monotherapy group, compared with those before treatment. H-BMD was significantly increased in the combination group(3.6%) compared with the denosumab group(1.2%) at 12 months(P < 0.05). Compared with denosumab monotherapy, combination therapy of denosumab with vitamin D and calcium stopped the decrease in calcium caused by denosumab, inhibited bone metabolism to a greater extent, and increased BMD(especially at the hips). | Yukio Nakamura Takako Suzuki Mikio Kamimura Kohei Murakami Shota Ikegami Shigeharu Uchiyama Hiroyuki Kato | 2017 | Bone Research2017，5，4： | 11 |
| 2 | Cost-profit analysis for Japan-Russia and Japan-South Korea interconnectors显示文摘This paper describes the results of cost-profit analysis related to interconnectors for Japan-Russia and JapanSouth Korea based on the Asia International Grid Connection Study Group 2^(nd) report. The Group has been established in 2016 for conducting research on international electric power networks in Asia from the viewpoint of technology, investment and legal framework. 2^(nd) report of the Group was published in June 2018, examining the profitability of an interconnectors between Japan and neighboring countries. The Group has calculated expected profit from operation of these interconnectors.The Group has categorized interconnector business into four models from the survey of preceding and current business on grids and interconnectors. To clarify profitability, expected internal rate of return(IRR) was calculated for each business model based on estimated investment cost for each route. When interconnector is dedicated to specific power plants or suppliers and electricity can be sold at Japan wholesale market at 2016-2017 price level, positive IRR levels are expected in case that Free on Board(FOB) price lower than 7 JPY/kWh. When the investment will be covered by electricity tariff by final consumers, tariff for consumers will just slightly increase by approximately 0.1 JPY/kWh. | Seiichiro Kimura Shota Ichimura | 2019 | Global Energy Interconnection2019，2，2： | 4 |
| 3 | Plastome phylogenomic insights into the Sino-Japanese biogeography of Diabelia(Caprifoliaceae)显示文摘Understanding the causes of the Sino-Japanese disjunctions in plant taxa has been a central question in eastern Asian biogeography,with vicariance or long-distance dispersal often invoked to explain such patterns.Diabelia Landrein(Caprifoliaceae;Linnaeoideae)comprises four shrubby species with a Sino-Japanese disjunct distribution.The species diversification time within Diabelia,covering a long geological history of the formation process of the Sino-Japanese flora,dated back to the middle Oligocene,therefore,Diabelia would be an ideal model to elucidate the biogeographic patterns of Sino-Japanese disjunctions with climate fluctuation.In this study,we analyzed complete plastome sequence data for 28 individuals representing all four species of Diabelia.These 28 plastomes were found to be highly similar in overall size(156243-157578 bp),structure,gene order,and content.Our phylogenomic analysis of the plastomes supported a close relationship between Diabelia ionostachya(Nakai)Landrein&R.L.Barrett var.wenzhouensis(S.L.Zhou ex Landrein)Landrein from eastern China and Diabelia spathulata(Siebold&Zucc.)Landrein var.spathulata from Japan.Diabelia serrata(Siebold&Zucc.)Landrein was identified as sister to a population of Diabelia sanguinea(Makino)Landrein from Tochigi in central Japan and D.spathulata Landrein,from Toyama,central Japan.Most Diabelia lineages were estimated to have differentiated 8-28 Mya.Our results indicate that two independent vicariance events could explain the disjunction between Japan and Korea in the mid to late Miocene,and between Zhejiang and Japan in the early Miocene. | Hong-Xin Wang Michael J.Moore Russell L.Barrett Sven Landrein Shota Sakaguchi Masayuki Maki Jun Wen Hua-Feng Wang | 2020 | Journal of Systematics and Evolution2020，58，6： | 3 |
| 4 | Indocyanine green fluorescence and three-dimensional imaging of right gastroepiploic artery in gastric tube cancer显示文摘A 79-year-old male was admitted to our hospital for the treatment of cancer of the gastric tube.Gastrointestinal examination revealed a T1 b Union for International Cancer Control(UICC) tumor at the pyloric region of the gastric tube.Laparotomy did not reveal infiltration intothe serosa,peritoneal dissemination,regional lymph node swelling,or distant metastasis.We performed a distal gastrectomy preserving the right gastroepiploic artery by referencing the preoperative three-dimensional computed tomoangiography.We also evaluated the blood flow of the right gastroepiploic artery and in the proximal gastric tube by using indocyanine green fluorescence imaging intra-operatively and then followed with a gastrojejunal anastomosis with Roux-en-Y reconstruction.The definitive diagnosis was moderately differentiated adenocarcinoma of the gastric tube,pT 1bN 0M0,pS tage IA(UICC).His postoperative course was uneventful.Three-dimensional computed tomographic imaging is effective for assessing the course of blood vessels and the relationship with the surrounding structures.Intraoperative evaluation of blood flow of the right gastroepiploic artery and of the gastric tube in the anastomotic portion is very valuable information and could contribute to a safe gastrointestinal reconstruction. | Toru Nakano Tadashi Sakurai Shota Maruyama Yohei Ozawa Takashi Kamei Go Miyata Noriaki Ohuchi | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 5 | Influence of texture feature size on spherical silicon solar cells显示文摘The effects of surface texturing on spherical silicon solar cells were investigated. Surface texturing for spherical Si solar cells was prepared by immersing p-type spherical Si crystals in KOH solution with stirring. Two kinds of texture feature sizes (1 and 5 μm pyramids) were prepared by changing stirring speed. After fabrication through our baseline processes, these cells were evaluated by solar cell performance and external quantum efficiency. The cell with 1 and 5 μm pyramids shows the short circuit current density (Jsc) value of 31.9 and 33.2 mA·cm-2, which is 9% and 13% relative increase compared to the cell without texturing. Furthermore, the cell with 5 μm pyramids has a higher open-circuit voltage (0.589 V) than the cell with 1 μm pyramids (0.577 V). As a result, the conversion efficiency was improved from 11.4% for the cell without texturing to 12.1% for the cell with 5 μm pyramids. | HAYASHI Shota MINEMOTO Takashi TAKAKURA Hideyuki HAMAKAWA Yoshihiro | 2006 | Rare Metals2006，25，z1： | 3 |
| 6 | Loss-of-Function of a Ubiquitin-Related Modifier Promotes the Mobilization of the Active MITE mPing显示文摘缩小的转换重复的 transposable 元素(螨) 在原核生物、真核细胞的染色体是普遍的,在他们的拷贝数字能达到几的地方千。然而,很少对影响他们的调换的基因因素被知道。这里,我们证明没有任何外长的压力,显著地编码象 ubiquitin 一样蛋白质的基因的那混乱在未经触动的米饭植物提高螨 mPing 的调换活动。我们发现 mPing 的调换活动在在 Rurm1 怀有非功能的等位基因的线更高是远的(瑞斯 ubiquitin 相关的 modifier-1 ) 地点比在野类型的线。尽管 cytosine methylation 模式的改变在外长的压力条件,在整个染色体的 methylation 度, mPing 身体区域,和胁腹 mPing 下面触发 transposable 元素的激活,非功能的 Rurm1 线的区域是未改变的。这研究为在房间以内的基因事故提高的染色体吃惊理论的模型之一提供试验性的证据 transposable 元素的调换活动。 | Takuji Tsukiyama Shota Teramoto KanakoYasuda Akira Horibata Nanako Mori Yutaka Okumoto Masayoshi Teraishi Hiroki Saito Akiko Onishi Kanako Tamura Takatoshi Tanisaka | 2013 | Molecular Plant2013，6，3： | 3 |
| 7 | Route designs and cost estimation for Japan-Russia and Japan-South Korea interconnections显示文摘This paper describes route designs and cost estimation for possible interconnections between Japan-Russia and between Japan-South Korea based on the Asia International Grid Connection Study Group 2^(nd) report. The Group has conducted a desktop study to design several cable routes as possible options. To optimize the route, the group studied a wide range of open data, regarding sea depth, fishery zones, geographic condition, available transmission capacity in connecting points inside Japan and so on. The result of desktop study shows that it is possible to keep sea depth for planned routes less than 300 m and length for most of designed routes is less than 600 km. Compare to existing undersea cables in Europe, proposed routes are not challenging from technical and geological viewpoints.The study shows that investment cost range, including cost for grid enhancement inside Japan, is from around 200 bn JPY to 600 bn JPY, depending on the routes. Annualized cost range is from around 8 to 24 bn JPY(for 25-year operation), which is not so large compare to 1800 bn JPY-average annual investment in transmission infrastructure by 10 power utilities in the past 23 years. | Shota Ichimura Ryo Omatsu | 2019 | Global Energy Interconnection2019，2，2： | 3 |
| 8 | Successful surgical resection of ruptured cholangiolocellular carcinoma:A rare case of a primary hepatic tumor显示文摘Spontaneous rupture is one of the most fatal complications of hepatic tumors such as hepatocellular carcinoma. In fact, many studies have shown that the in-hospital and 30-d mortality rates are as high as 25%-100%. Cholangiolocellular carcinoma(Co CC) is a rare primary hepatic tumor, usually small in size, that is thought to originate from the ductules and/or canals of Hering. Here, we present a case of spontaneous rupture of a Co CC that was successfully resected by radical surgery. Although Co CC is a rare primary hepatic tumor, it demonstrates certain specific clinical features, including a better prognosis than for other primary liver cancers, and thus should be distinguished from those other cancers. Moreover, Co CC can appear as a ruptured huge tumor, and when it does, radical hepatectomy can be an effective measure to achieve both absolute hemostasis and curability of tumor. | Shota Akabane Takushiro Ban Shunsaku Kouriki Hiroyuki Tanemura Haruhiro Nakazaki Masayuki Nakano Nobuaki Shinozaki | 2017 | World Journal of Hepatology2017，9，16： | 2 |
| 9 | Combined thoracoscopic and endoscopic surgery for a large esophageal schwannoma显示文摘A 47-year-old woman presented to our hospital with complaints of dysphagia. Esophagogastroduodenoscopy identified a submucosal tumor in the left wall of the esophagus that was diagnosed as a benign schwannoma on biopsy. Computed tomography revealed a tumor of length 60 mm in the thoracic esophagus, with its cranial edge at the level of the aortic arch. On endoscopy, a submucosal tunnel was created 40 mm proximal to the cranial edge of the tumor, and its oral end was dissected from the mucosal and muscular layers. This was followed by the resection of the entire tumor by left-sided thoracoscopy. The esophageal defect was closed in layer by continuous suture from the thoracic side. Endoscopic closure was achieved by using clips. No postoperative complications were observed. Oral diet was resumed from postoperative day 7 and the patient was discharged on postoperative day 9. This combined approach has not been described for similar tumors. Our experience demonstrated that large esophageal tumors can be safely excised with minimally invasive surgery by using a combination of thoracoscopy and endoscopy. | Yu Onodera Toru Nakano Daisuke Takeyama Shota Maruyama Yusuke Taniyama Tadashi Sakurai Takahiro Heishi Chiaki Sato Takuro Kumagai Takashi Kamei | 2017 | World Journal of Gastroenterology2017，23，46： | 2 |
| 10 | Rendezvous to asteroid with highly uncertain ephemeris: Hayabusa2’s Ryugu-approach operation result显示文摘This paper describes the guidance and navigation technique used by Hayabusa2 for the asteroid rendezvous operation to reach Ryugu.The operation results,including the achieved guidance and navigation performance,are also summarized.Multiple assessment and navigation teams worked closely to provide reliable navigation solutions with a short solution delivery cycle.Although the uncertainty of the Ryugu’s ephemeris was considerable before Hayabusa2’s arrival,a combination of radiometric-optical hybrid navigation and a stochastic-constrained optimum guidance method was able to achieve an accuracy of less than 100 m and 1 cm/s,and the arrival was precisely timed. | Yuichi Tsuda Hiroshi Takeuchi Naoko Ogawa Go Ono Shota Kikuchi Yusuke Oki Masateru Ishiguro Daisuke Kuroda Seitaro Urakawa Shin-ichiro Okumura Hayabusa2 Project Team | 2020 | Astrodynamics2020，4，2： | 2 |
| 11 | Dynamical model of HEV with two planetary gear units and its application to optimization of energy consumption显示文摘A hybrid electric vehicle(HEV) that uses multiple planetary gear units with clutches as transmission system is advanced for the powertrain performance, because the operation of the clutches can lead to distinct operating modes, and the induced possible operating modes provide additional freedom to deal with the energy optimal control problem. Under each operating mode, the powertrain mechanical system has specific dynamical behavior. In order to develop model-based optimization schemes that can tackle the transient operations of the vehicle, exact dynamical modeling is investigated focusing on a hybrid powertrain system that uses a two-planetary-gear transmission box with two clutches. It shows that according to the states of the two clutches, the powertrain system has the power-split mode, parallel mode and the electric vehicle(EV) mode. Finally, an analysis for the calculation of the desired driving torque and its application to the dynamic programming(DP)-based energy management indicate the significance of the developed exact dynamical models. | Jiangyan ZHANG Shota INUZUKA Takafumi KOJIMA Tielong SHEN Junichi KAKO | 2019 | Science China(Information Sciences)2019，62，12： | 2 |
| 12 | Napkin-Ring Sign on Coronary CT Angiography for the Prediction of Acute Coronary Syndrome显示文摘 | Kenichiro Otsuka Shota Fukuda Atsushi Tanaka Koki Nakanishi Haruyuki Taguchi Junichi Yoshikawa Kenei Shimada Minoru Yoshiyama | 2013 | JACC: Cardiovascular Imaging2013，，4： | 2 |
| 13 | The deep-space multi-object orbit determination system and its application to Hayabusa2’s asteroid proximity operations显示文摘The deep-space multi-object orbit determination system(DMOODS)and its application in the asteroid proximity operation of the Hayabusa2 mission are described.DMOODS was developed by the Japan Aerospace Exploration Agency(JAXA)for the primary purpose of determining the trajectory of deep-space spacecraft for JAXA’s planetary missions.The weighted least-squares batch filter is used for the orbit estimator of DMOODS.The orbit estimator supports more than 10 data types,some of which are used for relative trajectory measurements between multiple space objects including natural satellites and small bodies.This system consists of a set of computer programs running on Linux-based consumer PCs on the ground,which are used for orbit determination and the generation of radiometric tracking data,such as delta differential one-way ranging and doppler tracking data.During the asteroid proximity phase of Hayabusa2,this system played an essential role in operations that had very strict navigation requirements or operations in which few optical data were obtained owing to special constraints on the spacecraft attitude or distance from the asteroid.One example is orbit determination during the solar conjunction phase,in which the navigation accuracy is degraded by the effect of the solar corona.The large range bias caused by the solar corona was accurately estimated with DMOODS by combining light detection and ranging(LIDAR)and ranging measurements in the superior solar conjunction phase of Hayabusa2.For the orbiting operations of target markers and the MINERVA-II2 rover,the simultaneous estimation of six trajectories of four artificial objects and a natural object was made by DMOODS.This type of simultaneous orbit determination of multi-artificial objects in deep-space has never been accomplished before. | Hiroshi Takeuchi Kent Yoshikawa Yuto Takei Yusuke Oki Shota Kikuchi Hitoshi Ikeda Stefania Soldini Naoko Ogawa Yuya Mimasu Go Ono Fuyuto Terui Naoya Sakatani Manabu Yamada Toru Kouyama Shingo Kameda Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 2 |
| 14 | The preoperative plasma D-dimer level is an independent prognostic factor in patients with completely resected non-small cell lung cancer显示文摘 | Koichi Fukumoto Tetsuo Taniguchi Noriyasu Usami Koji Kawaguchi Takayuki Fukui Futoshi Ishiguro Shota Nakamura Kohei Yokoi | 2015 | Surgery Today2015，，1： | 2 |
| 15 | Two-year clinical outcome of denosumab treatment alone and in combination with teriparatide in Japanese treatment-naive postmenopausal osteoporotic women显示文摘This randomized prospective study aimed to evaluate the clinical outcome of denosumab treatment alone and in combination with teriparatide in treatment-naive postmenopausal Japanese female patients with osteoporosis. Thirty patients were randomly assigned to two groups:(1) denosumab group(denosumab alone, n=13); and(2) combination group(denosumab+teriparatide, n=17). Serum bone-specific alkaline phosphatase(BAP), serum tartrate-resistant acid phosphatase(TRACP)-5b, urinary cross-linked N-terminal telopeptides of type I collagen(NTX), and bone mineral density(BMD) of L1–4 lumbar vertebrae(L-BMD)and bilateral total hips(H-BMD) were determined at the first visit and at various time points up to 24 months post-treatment to determine percentage changes. Serum TRACP-5b and urinary NTX were equally suppressed in both groups and maintained at low levels, with slight increases at 12, 18 and 24 months. BAP was significantly decreased in both groups from 4 to 24 months, with significant differences between the groups at 4, 8 and 15 months(P<0.05). L-BMD was significantly increased at most time points in both groups, with a significant difference between the combination group and denosumab group at 24 months(17.2% increase versus 9.6% increase; P<0.05). There was no significant difference in H-BMD between the two groups, although the levels tended to be higher in the combination group than in the denosumab group(9.5% increase versus 5.6% increase). These findings suggest that denosumab+teriparatide combination therapy may represent an important treatment for primary osteoporotic patients at high risk of vertebral fracture. | Yukio Nakamura Takako Suzuki Mikio Kamimura Shota Ikegami Kohei Murakami Shigeharu Uchiyama Akira Taguchi Hiroyuki Kato | 2017 | Bone Research2017，5，2： | 2 |
| 16 | Effects of Rice- related Products on the Textural Properties and Color of Fish Meat Gels Derived from Walleye Pollock ( Theragra chalcagramma) 显示文摘 | Tanimoto Shota Tomioka | 2013 | Food Science and Technology Research2013，19，3： | 1 |
| 17 | Changes in serum cholesterol levels determine future risk of cardiovascular events in patients with acute coronary syndrome in the Japanese Coronary Artery Disease (JCAD) Study显示文摘 | Shota Fukuda Kenei Shimada Masatoshi Fujita Minoru Yoshiyama Junichi Yoshikawa Takahide Kohro Doubun Hayashi Tsutomu Yamazaki Ryozo Nagai | 2013 | Journal of Cardiology2013，，6： | 1 |
| 18 | Clinical application of hyperthermia combined with anticancer drugs for the treatment of solid tumors显示文摘 | Ikuo T Yasunori E Shota H | 2002 | Surgery2002，131，1： | 1 |
| 19 | Realization of high strength and high ductlity for AZ61magnesium alloy by severe warm working显示文摘 | Yu Yoshida Keita Arai Shota Itoh | 2005 | Science and Technology of Advanced Materials2005，6，2： | 1 |
| 20 | Phenotypic and functional properties of feline dedifferentiated fat cells and adipose-derived stem cells显示文摘 | Shota Kono Tomohiko Kazama Koichiro Kano Kayoko Harada Masami Uechi Taro Matsumoto | 2013 | The Veterinary Journal2013，，： | 1 |
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