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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Analysis of a quantitative trait locus allele from wild soybean that increases seed protein concentration in soybean显示文摘 | Sebolt A M Shoemaker R C Diers B W | 2000 | Crop Science2000，40，5： | 1 |
| 3 | Lunar surface topography显示文摘 | Rennilson J J Dragg J L Morris E C Shoemaker E M Turkevich A | 1966 | Surveyor I mission report part Ⅱ:Scientific data and results NASA JPL Technical Report1966，32，： | 1 |
| 4 | Integration of simple sequence repeat DNA markers into a soybean linkage map 显示文摘 | Akkaya M S Shoemaker R C Specht J E | 1995 | Crop Sci1995，35，5： | 1 |
| 5 | First natural occurrence of coesite 显示文摘 | Chao E C T Shoemaker E M Madsen B M | 1960 | Science1960，132，： | 1 |
| 6 | Graphical methods for assessing logistic regression models显示文摘 | Landwehr J M Pregibon D Shoemaker A C | 1984 | Journal of the Ameri- can Statistical Association1984，79，385： | 1 |
| 7 | Influence of ensemble surrogate models and sampling strategy on the solution quality of algorithms for computationally expensive black-box global optimization problems 显示文摘 | Müller J Shoemaker C A | 2014 | Journal of Global Optimization2014，60，2： | 1 |
| 8 | Resistance gene analogs are conserved and clustered in soybean 显示文摘 | Kanazin V M Marek L F Shoemaker R C | 1996 | Proc Natl Acad Sei USA1996，93，11： | 1 |
| 9 | Efficacy of a modified live Edwarsiella ictaluri vaccine in channel catfish as young as seven days post hatch 显示文摘 | Shoemaker C A Klesius P H Bricker J M | 1999 | Aquaculture1999，176，： | 1 |
| 10 | First Natural Occurrence of Coesite显示文摘 | Chao E C T Shoemaker E M Madsen B M | 1960 | Science1960，132，： | 1 |
| 11 | Prospective,randomized trial of survivor values of cardiac index, oxygen delivery,and oxygen consumption as resuscitation endpoints in severe trauma显示文摘 | Bishop M H Shoemaker W C Appel P L | 1995 | J Trauma1995，38，： | 1 |
| 12 | Integration of simple sequence repeat DNA markers into a soybean linkage map 显示文摘 | Akkaya M S Shoemaker R C Specht J E | 1995 | Crop Science1995，35，： | 1 |
| 13 | Noninvasive estimations of cardiac output and circulatory dynamics in critically ill patients显示文摘 | Wo C C J Shoemaker W C Bishop M H | 1995 | Curr Opin Crit Care1995，1，： | 1 |
| 14 | Multicenter trial of a new thoracic electrical bioimpedance device for cardiac output estimation显示文摘 | Shoemaker W C Wo C C Bishop M H | 1994 | Crit Care Med1994，12，： | 1 |
| 15 | Identification of a RAPD marker introductions and North American ancestors using RAPD and SSR markers 显示文摘 | Byrum J R Kimbirauskas P M Shoemaker R C | 1993 | Soybean Genetic Newsletter1993，20，： | 1 |
| 16 | Analyzing the coordinated gene network underlying temperature-dependent sex determination in reptiles显示文摘 | Shoemaker C M Crews D | 2009 | Seminars in Cell & Developmental Biology2009，20，3： | 1 |
| 17 | Noninvasive hemodynamic monitoring of acutely ill patients admitted to the emergency department显示文摘 | Shoemaker W C Wo C C Bishop M H | 1996 | Acad Emerg Med1996，3，： | 1 |
| 18 | Integration of simple sequence repeat DNA markers into a soybean linkagemap 显示文摘 | Akkaya M S Shoemaker R C Specht J E | 1995 | Crop Science1995，35，： | 1 |
| 19 | Noninvasive estimations of cardiac output and circulatory dynamics in critically ill patients显示文摘 | Wo C C J Shoemaker W C Bishop M H | 1995 | Curr Opin Crit Care1995，1，： | 1 |
| 20 | Expression of Sox9, Mis, and Dmrt1 in the gonad of a species with temperature-dependent sex determination显示文摘 | Shoemaker C Ramsey M Queen J | 2007 | Developmental Dynamics2007，236，4： | 1 |
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