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| 1 | ECCM scheme against interrupted sampling repeater jammer based on time-frequency analysis显示文摘The interrupted sampling repeater jamming(ISRJ) is an effective deception jamming method for coherent radar, especially for the wideband linear frequency modulation(LFM) radar. An electronic counter-countermeasure(ECCM) scheme is proposed to remove the ISRJ-based false targets from the pulse compression result of the de-chirping radar. Through the time-frequency(TF) analysis of the radar echo signal, it can be found that the TF characteristics of the ISRJ signal are discontinuous in the pulse duration because the ISRJ jammer needs short durations to receive the radar signal. Based on the discontinuous characteristics a particular band-pass filter can be generated by two alternative approaches to retain the true target signal and suppress the ISRJ signal. The simulation results prove the validity of the proposed ECCM scheme for the ISRJ. | Shixian Gong Xizhang Wei Xiang Li | 2014 | Journal of Systems Engineering and Electronics2014，25，6： | 24 |
| 2 | Mathematic principle of active jamming against wideband LFM radar显示文摘The inherent mathematic principle of active jamming against the wideband linear frequency modulated(LFM) radar is investigated. According to different generation strategies, the active jamming methods are reclassified into three groups, i.e.,non-coherent jamming(NCJ), convolution jamming(CJ) and multiplying jamming(MJ). Based on the classification, the mathematic principles of different active jamming groups are put forward, which describe the relationships between the modulated signals and the jamming results. The advantages and disadvantages of different groups are further analyzed, which provides a new perspective for the study of jamming/anti-jamming methods and a potential for engineers to integrate similar jamming methods into one jammer platform. The analyses and simulation results of some typical active jamming methods prove the validity of the proposed mathematics principle. | Shixian Gong Xizhang Wei Xiang Li Yongshun Ling | 2015 | Journal of Systems Engineering and Electronics2015，26，1： | 10 |
| 3 | Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment显示文摘Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemic circulation,and lack of cancer-selective drug release.Herein,a poly(ethylene glycol)(PEG)-polyphosphoester-based,reactive oxygen species (ROS)-responsive,core-cross-linked (CCL) micellar system was developed to encapsulate both chemodrug (doxorubicin,Dox) and photosensitizer (chlorin e6,Ce6).The hydrophobic core of the micelles was cross-linked via a thioketal (TK)-containing linker,which notably enhanced the drug loading and micelle stability.In tumor cells,far-red light irradiation of Ce6 generated ROS to cleave the TK linkers and disrupt the micelle cores.As such,micelles were destabilized and Dox release was promoted,which thereafter imparted synergistic anti-cancer effect with ROS-mediated photodynamic therapy.This study provides an effective approach to realize the precise control over drug loading,formulation stability,and cancer-selective drug release using polymeric micelles,and would render promising utilities for the programmed anti-cancer combination therapy. | Yongjuan Li Jian Hu Xun Liu Yong Liu Shixian Lv Juanjuan Dang Yong Ji Jinlin He Lichen Yin | 2019 | Nano Research2019，12，5： | 5 |
| 4 | Preparation of fluidized catalytic cracking slurry oil-in-water emulsion as anti-collapse agent for drilling fluids显示文摘Fluidized catalytic cracking slurry oil-in-water emulsion(FCCSE)was prepared by using interfacial complexes generation method that was simple and versatile.The critical factors influencing the sample preparation process were optimized,for instance,the optimum value of the mixed hydrophile-lipophile balance of compound emulsifier was 11.36,the content of compound emulsifier was 4 wt%,the emulsification temperature was 75C,the agitation speed was 200 rpm,and the emulsification time was 30e45 min.The performance as a drilling fluid additive was also investigated with respect to rheological properties,filtration loss and inhibition of FCCSE.Experimental results showed that FCCSE was favorable to inhibiting clay expansion and dispersion and reducing fluid loss.Furthermore,it had good compatibility with other additives and did not affect the rheological properties of drilling fluids.FCCSE exhibited better performance than the available emulsified asphalt.It has a promising application as anti-collapse agent in petroleum and natural gas drilling. | Zhengqiang Xiong Shixian Tao Xiaodong Li Fan Fu Yanning Li | 2016 | Petroleum2016，2，4： | 4 |
| 5 | Exploration of Multifocal Rod Electroretinograms Recording in Human显示文摘Purpose:To test the feasibility of recording rod multifocal electroretinograms (ERG) in humans and observe appropriate recording conditions.Methods: Multifocal rod ERG were recorded using a stimulus array of 61 equalsized hexagons in two normal subjects after the dark adaptation. Flashes were blue (W47B). Blank frames between two successive flashes of hexagons varied from 0 to 14. Length of the m-sequence, bandwidth, flash frequency, flash intensities and background intensities were changed to obtain appropriate recording conditions for the clinical use.Results:Multifocal rod ERG were clearly recordable and well formed. They had an early implicit time, very small negative wave and a late implicit time, large positive wave. The positive wave was bimodal, whose timing and waveform were similar to the full-field rod ERG. The local response amplitudes can be suppressed with increase in flash frequency or background intensity, decrease in flash intensity or the size of stimulus elements.Conclusions: Multifocal rod ERG can be recorded in human and can provide topographical maps of retinal function that have clinical usage. 212-1 m-sequence length, 3F blank frames and 3~ 300 Hz bandwidth were suggested to appropriate recording conditions. | Changzheng Chen, Lezheng Wu, De-Zheng Wu, Shixian Long Jiongji Liang, Futian Jiang, Libing JiangZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2002 | 眼科学报2002，18，3： | 3 |
| 6 | Preparation of ultrafine WC-Co cermets by combining pretreatment and consolidation with spark plasma sintering显示文摘Ultrafine-grained WC-Co bulk materials were prepared by a new method that contains pretreatment of the milled powder mixture and subsequent spark plasma sintering (SPS). Ball milling parameters and the pretreatment temperature have significant effects on the microstructure and properties of WC-Co cermets. The prepared cermets have a mean grain size of less than 0.5 μm even with a pretreatment temperature as high as 1300°C. The WC-10wt.%Co cermet bulk prepared by the optimized milling, pretreatment, and SPS processing achieves excellent mechanical properties with a Vickers hardness of HV 1643, a fracture toughness of 13.1 MPa?m1/2 and a transverse rapture strength of 3100 MPa. | ZHAO Shixian SONG Xiaoyan WANG Mingsheng LIU Guoquan ZHANG Jiuxing | 2009 | Rare Metals2009，28，4： | 3 |
| 7 | Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure显示文摘Acute liver failure(ALF),a fatal clinical disease featured with overwhelming hepatocyte necrosis,is a grand challenge in global health.However,a satisfactory therapeutic option for curing ALF is still absent,other than liver transplantation.Nanobiomaterials are currently being developed for the diagnosis and treatment of ALF.The liver can sequester most of nanoparticles from blood circulation,which becomes an intrinsic superiority for nanobiomaterials targeting hepatic diseases.Nanobiomaterials can enhance the bioavailability of free drugs,thereby significantly improving the therapeutic effects in ALF.Nanobiomaterials can also increase the liver accumulation of therapeutic agents and enable more effective targeting of the liver or specific liver cells.In addition,stimuli-responsive,optical,or magnetic nanomaterials exhibit great potential in the therapeutical,diagnostic,and imaging applications in ALF.Therefore,therapeutic agents in combination with nanobiomaterials increase the specificity of ALF therapy,diminish adverse systemic effects,and offer a multifunctional theranostic platform.Nanobiomaterial holds excellent significance and prospects in ALF theranostics.In this review,we summarize the therapeutic mechanisms and targeting strategies of various nanobiomaterials in ALF.We highlight recent developments of diverse nanomedicines for ALF therapy,diagnosis,and imaging.Furthermore,the challenges and future perspectives in the theranostics of ALF are also discussed. | Yuanyuan Jin Haixia Wang Ke Yi Shixian Lv Hanze Hu Mingqiang Li Yu Tao | 2021 | Nano-Micro Letters2021，13，2： | 3 |
| 8 | Linking plant spatial aggregation with reproductive traits and near-source seed dispersal: ecological adaptation to heavy grazing显示文摘植物的生态适应策略一直备受生态学者的关注,然而很少有研究能够整体地、系统地揭示植物适应草食动物的生态过程。本研究以内蒙古荒漠草原建群种短花针茅为研究对象,分析了重度放牧和不放牧处理下短花针茅的繁殖个体性状、种子性状以及土壤种子库和种群空间格局。研究结果表明,生殖个体性状方面,生殖枝数量对营养枝数量有正向影响;土壤种子库方面,短花针茅生殖个体基部的土壤种子库中短花针茅密度显著高于旁边裸地土壤种子库中短花针茅的密度,且与种子性状和裸地土壤种子库显著负相关;在种群空间格局方面,重度放牧下短花针茅种群空间聚集分布。我们的结果认为在重度放牧处理下,生殖活动在短花针茅的资源分配中处于主导地位;短花针茅植物种群通过调控种子形态特征,采用就近扩散的生态策略,促进了幼年种群与成年种群在较小的尺度上空间正关联,从而形成“安全岛”。 | Wenting Liu Shixian Sun Chunping Zhang Shijie Lv Quanmin Dong | 2020 | Journal of Plant Ecology2020，13，4： | 2 |
| 9 | Cardiomyocyte-targeted anti-inflammatory nanotherapeutics against myocardial ischemia reperfusion (IR) injury显示文摘Myocardial ischemia reperfusion(IR)injury is closely related to the overwhelming inflammation in the myocardium.Herein,cardiomyocyte-targeted nanotherapeutics were developed for the reactive oxygen species(ROS)-ultrasensitive co-delivery of dexamethasone(Dex)and RAGE small interfering RNA(siRAGE)to attenuate myocardial inflammation.PPTP,a ROSdegradable polycation based on PGE2-modified,PEGylated,ditellurium-crosslinked polyethylenimine(PEI)was developed to surface-decorate the Dex-encapsulated mesoporous silica nanoparticles(MSNs),which simultaneously condensed siRAGE and gated the MSNs to prevent the Dex pre-leakage.Upon intravenous injection to IR-injured rats,the nanotherapeutics could be efficiently transported into the inflamed cardiomyocytes via PGE2-assisted recognition of over-expressed E-series of prostaglandin(EP)receptors on the cell membranes.Intracellularly,the over-produced ROS degraded PPTP into small segments,promoting the release of siRAGE and Dex to mediate effective RAGE silencing(72%)and cooperative antiinflammatory effect.As a consequence,the nanotherapeutics notably suppressed the myocardial fibrosis and apoptosis,ultimately recovering the systolic function.Therefore,the current nanotherapeutics represent an effective example for the codelivery and on-demand release of nucleic acid and chemodrug payloads,and might find promising utilities toward the synergistic management of myocardial inflammation. | Min Lan Mengying Hou Jing Yan Qiurong Deng Ziyin Zhao Shixian Lv Juanjuan Dang Mengyuan Yin Yong Ji Lichen Yin | 2022 | Nano Research2022，15，10： | 2 |
| 10 | Stochastic stabilization using aperiodically sampled measurements显示文摘This paper addresses the stabilization problem of sector-bounded nonlinear systems with sampled measurements via discrete-time stochastic feedback control. Unlike the previous studies, the closed-loop system is modeled as an impulsive stochastic differential equation. By developing a quasi-periodic polynomial Lyapunov function and sampling-time-dependent Lyapunov function based methods, two sufficient conditions for almost sure exponential stability are derived in terms of differential matrix inequalities(DMIs) and linear matrix inequalities(LMIs). It is shown that the DMI-based conditions can be formulated as a sum of squares(SOSs). Moreover, the obtained results are adapted to sampled-data stochastic/deterministic systems. The numerical examples illustrate the theoretical results. | Shixian LUO Feiqi DENG Xueyan ZHAO Zhipei HU | 2019 | Science China(Information Sciences)2019，62，9： | 2 |
| 11 | Defining a critical period in calvarial development for Hedgehog pathway antagonist-induced frontal bone dysplasia in mice显示文摘The Hedgehog(Hh) signalling pathway is essential for cellular proliferation and differentiation during embryonic development.Gain and loss of function of Hh signalling are known to result in an array of craniofacial malformations. To determine the critical period for Hh pathway antagonist-induced frontal bone hypoplasia, we examined patterns of dysmorphology caused by Hh signalling inhibition. Pregnant mice received a single oral administration of Hh signalling inhibitor GDC-0449 at 100 or 150 mg·kg^(-1) body weight at preselected time points between embryonic days(E)8.5 and 12.5. The optimal teratogenic concentration of GDC-0449 was determined to be 150 mg·kg^(-1). Exposure between E9.5 and E10.5 induced frontal bone dysplasia, micrognathia and limb defects, with administration at E10.5 producing the most pronounced effects. This model showed decreased ossification of the frontal bone with downregulation of Hh signalling. The osteoid thickness of the frontal bone was significantly reduced. The amount of neural crest-derived frontal bone primordium was reduced after GDC-0449 exposure owing to a decreased rate of cell proliferation and increased cell death. | Yuanjing Jiang Shixian Zhang Chuanqing Mao Yongzhen Lai Di Wu Hu Zhao Caiyu Liao Weihui Chen | 2019 | International Journal of Oral Science2019，11，1： | 2 |
| 12 | Nonenzymatic hydrolysis of cocaine via intramolecular acid catalysis显示文摘 | Li Pan Zhao Kang Deng Shixian | 1999 | Helv Chim Acta1999，82，： | 1 |
| 13 | Effects of WC particle size on densification and properties of spark plasma sintered WC-Co cermet显示文摘 | Shixian Zhao Xiaoyan Song Chongbin Wei | 2009 | International Journal of Refractory Metals and Hard Materials2009，27，6： | 1 |
| 14 | Flexible robot beam element for the manipulators with joint and link flexibility显示文摘 | Yue Shigang Yu Yueqing Bai Shixian | 1997 | Mechanism and Machine theory1997，32，2： | 1 |
| 15 | Equal inclination interference principles in a rectangular cavity and in an isosceles wedge 显示文摘 | Zhou Guoquan Sui Shixian | 1994 | Optical Engineering1994，26，3： | 1 |
| 16 | Devel- opment and Application of Anti-collapse & Anti-drag Agent for Drilling Fluid显示文摘 | Xiong - Zhengqiang Tao - Shixian Li - Xiaodong | 2014 | Procedia Engineering2014，73，： | 1 |
| 17 | Ecological risk assessment for aquatic species exposed to contaminants in Keelung River, Taiwan 显示文摘 | CHEN Shixian | 2005 | Chemosphere2005，61，： | 1 |
| 18 | Review and Evaluation of the Energy Strategy and Policy显示文摘 | Gao Shixian Qu Shiyuan Geng Zhicheng | 2004 | Review of Economic Research2004，，83： | 1 |
| 19 | Flexible Rotor Beam Element for the Manipulators with Joint and L ink Flexibility显示文摘 | Yue Shigang Yu Yueqing Bai Shixian | 1997 | Mech Mach Theory1997，，： | 1 |
| 20 | Lack of association between the G protein β3 subunit gene and essential hypertension in Chinese: a case-control and a family-based study显示文摘 | Xiaohong Huang Zhenyu Ju Yan Song Hongye Zhang Kai Sun Hongyan Lu Zhiwei Yang Pedro A. Jose Gang Zhou Meng Wang Weifeng Wang Shixian Feng Rutai Hui | 2003 | Journal of Molecular Medicine2003，，11： | 1 |
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