|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 2 | Plastic and elastic properties of compositionally modulated thin films显示文摘 | BARNETT S A SHINN M | 1994 | Annual Reviews in Materials Science1994，24，： | 1 |
| 3 | Growth, structure and microhardness of epitaxial TiN/NbN superlattices显示文摘 | Shinn M Huhman L Barnett S A | 1992 | J Mater Res1992，7，4： | 1 |
| 4 | An X-ray diffrac- tion study of epitaxial TiN/NbN superlattiees 显示文摘 | MADAN A YASHAR P SHINN M | 1997 | Thin SolidFilm1997，302，12： | 1 |
| 5 | Phasic Burst Stimula- tion: A Closed-Loop Approach to Tuning Deep Brain Stimulation Parameters for Parkinson's Disease 显示文摘 | Holt AB Wilson D Shinn M | 2016 | PLoS Comput Biol2016，12，10： | 1 |
| 6 | Mechanical and chemical compaction in fine-grained shallow-water limestones显示文摘 | Shinn E A Robbin D M | 1983 | Journal of Sedimentary Research1983，53，2： | 1 |
| 7 | Synthesis of highly oriented TiNx coatings by free-electron laser processing of titanium in nitrogen gas显示文摘 | Carpene E Shinn M Schaaf P | 2004 | Appl Phys A2004，10，： | 1 |
| 8 | Plastic and Elastic Properties of Compositionally Modulated Thin Films显示文摘 | Barnett S A Shinn M | 1994 | Annual Review of Materials Science1994，24，： | 1 |
| 9 | Optical transitions of Er^3+ ions in fluorozirconate glass显示文摘 | SHINN M D SIBLEY W A DREXHAGE M G | 1983 | Phys Rev (B)1983，27，11： | 1 |
| 10 | Growth, Structure, and Micro-Hardness of Epitaxial TiN/NbN Super-Lattices显示文摘 | Shinn M Hultman L Barnett S A | 1992 | Journal of Materials Research1992，7，4： | 1 |
| 11 | Spectroscopic,Optical,and Thermomechanical Properties of Neodymium-doped and Chromiumdoped Gadolinium Scandium Gallium Garnet显示文摘 | Krupke W F Shinn M D Marion J E | 1986 | Journal of the Optical Society of America B-Optical Physics1986，3，1： | 1 |
| 12 | Effect of superlattice layer elastic moduli on hardness显示文摘 | Shinn M Barnett S | 1994 | Appl Phys Lett1994，64，1： | 1 |
| 13 | Development of a CPT deployed probe for in situ measurement of volumetric soil moisture content and electrical resistivity显示文摘 | Shinn J D Timian D A Morey R M | | 0，，1086： | 1 |
| 14 | Common sequence polymorphisms shaping genetic diversity in Arabidopsis thaliana显示文摘 | Clark R M Schweikert G Toomajian C Ossowski S Zeller G Shinn P Warthmann N Hu T T Fu G Hinds D A | | 0，，： | 1 |
| 15 | Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis 显示文摘 | Zhang X Yazaki J Sundaresan A Cokus S Chan SW Chen H Henderson I R Shinn P Pellegrini M Jacobsen S E Ecker J R | 2006 | Cell2006，126，6： | 1 |
| 16 | Growth, Structure, and Microstructure of Epitaxial TiN/VN Superlattices显示文摘 | Hultman L Barnett S A | 1992 | J Mater Res1992，7，4： | 1 |
| 17 | Significance of Cardiac troponin T release after percutaneous transluminal coronary angioplasty显示文摘 | Karim MA Shinn M Oskarsson H | 1995 | Am J Cardiol1995，76，： | 1 |
| 18 | African dust and the demise of Caribbean coral reefs 显示文摘 | SHINN E A SMITH G W PROSPERO J M | 2000 | Geophysical Research Letters2000，27，： | 1 |
| 19 | Significance of cardiac troponin T release after percutaneous transluminal coronary angioplasty 显示文摘 | Shinn M Oskarsson H Windle J Deligonul V | 1995 | Am J Cardiol1995，76，7： | 1 |
| 20 | Growth, struc- ture, and microhardness of epitaxial TiN/NbN superlattices 显示文摘 | SHINN M HULTMAN L BARRETT S A | 1992 | J Mat Res1992，7，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员