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| 1 | Opioid peptides derived from wheat gluten:their isolation and characterization显示文摘 | Shinichi F Masaaki Y | 1992 | FEBS Letters1992，296，1： | 1 |
| 2 | Gluten exorphin C:a novel opioid peptide derived from wheat gluten显示文摘 | Shinichi F Masaaki Y | 1993 | FEBS Letters1993，316，1： | 1 |
| 3 | Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells显示文摘 | Shinichi F Saner B | 1992 | Proc Natl Acad Sci USA1992，89，： | 1 |
| 4 | Rotational atherectomy followed by cutting-balloon plaque modification for drug-elut-ing stent implantation in calcified coronary lesions显示文摘 | Shinichi F Tetsuya T Ryuta A | | 0，，： | 1 |
| 5 | Evaluation of Scenario- based Modularization for Lifecycle Design 显示文摘 | Yasushi U Shinichi F Keita T | 2009 | CIRP Annals - Manufacturing Technology2009，58，1： | 1 |
| 6 | 3-D Numerical Simulations of Non-isothermal Flow in Co-rotating Twin Screw Extruders显示文摘 | Takeshi I Shinichi K Kazumori F | 2000 | Polymer Engineering and Science2000，40，2： | 1 |
| 7 | Rapid detection of norovirus from fecal specimens by real-time reverse transcriptionloop-mediated isothermal amplification assay显示文摘 | Shinji F Shinichi T Masaru K | 2006 | J Clin Microbio2006，44，4： | 1 |
| 8 | Prevalence and clinieoepide- miologieal features of moyamoya disease in Japan: Findings from a nationwide epidemiologlcal survey 显示文摘 | Shinichi K Yasuko K Miki F | 2008 | Stroke2008，39，1： | 1 |
| 9 | Effi- cient field emission from an individual aligned carbon nano- tube bundle enhanced by edge effect 显示文摘 | SHUNJIRO F SHINICHI H HIRONOBU M | 2007 | Appl Phys Lett2007，90，15： | 1 |
| 10 | Long-term use of en- tecavir in nucleoside-na'fve Japanese patients with chronic hepatitis B infection 显示文摘 | OSAMU Y KOICHI T SHINICHI F | 2010 | J Hepatology2010，52，6： | 1 |
| 11 | Release of opioid peptides,gluten exorphins by tile action of pancreatic elastase显示文摘 | SHINICHI F YUNDEN J TAIJI M | 1997 | FEBS letter1997，，： | 1 |
| 12 | A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease显示文摘AIM: To study a more accurate quantification of hepatic fibrosis which would provide clinically useful information for monitoring the progression of chronic liver disease. METHODS: Using a cDNA microarray containing over 22 000 clones, we analyzed the gene-expression profiles of non-cancerous liver in 74 patients who underwent hepatic resection. We calculated the ratio of azan- stained: total area, and determined the morphologic fibrosis index (MFI), as a mean of 9 section-images. We used the MFI as a reference standard to evaluate our method for assessing liver fibrosis. RESULTS: We identified 39 genes that collectively showed a good correlation (r > 0.50) between gene-expression and the severity of liver fibrosis. Many of the identified genes were involved in immune responses and cell signaling. To quantify the extent of liver fibrosis, we developed a new genetic fibrosis index (GFI) based on gene-expression profiling of 4 clones using a linear support vector regression analysis. This technique, based on a supervised learning analysis, correctly quantified the various degrees of fibrosis in both 74 training samples (r = 0.76, 2.2% vs 2.8%, P < 0.0001) and 12 independent additional test samples (r = 0.75, 9.8% vs 8.6%, P < 0.005). It was far better in assessing liver fibrosis than blood markers such as prothrombin time (r = -0.53), type Ⅳ collagen 7s (r = 0.48), hyaluronic acid (r = 0.41), and aspartate aminotransferase to platelets ratio index (APRI) (r = 0.38). CONCLUSION: Our cDNA microarray-based strategy may help clinicians to precisely and objectively monitor the severity of liver fibrosis. | Tohru Utsunomiya Masahiro Okamoto Shigeki Wakiyama Masaji Hashimoto Kengo Fukuzawa Takahiro Ezaki Shinichi Aishima Yasuji Yoshikawa Taizo Hanai Hiroshi Inoue Graham F Barnard Masaki Mori | 2007 | World Journal of Gastroenterology2007，13，3： | 1 |
| 13 | Does increased QT dispersion in the acute phase of anterior myocardial infarctionpredict recovery of left ventricular wall motion显示文摘 | Tamio NJ Shinichi F Shiro V | 1998 | J Electrocardiol1998，1，： | 1 |
| 14 | Determination of ag i ion and arginine by using the composite film of electroinactive polypyrrole and polyion complex显示文摘 | Shinichi K Yusuke F Tomoka M | 1998 | Sensors and Actuators B1998，，52： | 1 |
| 15 | Product modularity for life cycle design 显示文摘 | Yasushi U Shinichi F Keita T | 2008 | CIRP Annals - Manufacturing Technology2008，128，57： | 1 |
| 16 | Product modularity for life cyele design 显示文摘 | YASUSHI U SHINICHI F | 2008 | C1RP Annals-manufacturing Technology2008，57，： | 1 |
| 17 | Characteristics of oriented LaNiO3 thin films fabricated by the sol gel method显示文摘 | SHINICHI M SHINOBU F TOSHIO K | 2001 | European Ceramic Society2001，21，10： | 1 |
| 18 | Strain improvement of Acremonium cellulolyticus for cellulase production by mutation显示文摘 | Xu F Shinichi Y Hiroyuki l | 2009 | J Biosei Bioeng2009，107，3： | 1 |
| 19 | Altered blood B lymphocyte homeostasis in systemic sclerosis expanded naive B cells and diminished but activated memory B cells显示文摘 | Shinichi S Manabu F Minoru H | 2004 | Arthritis Rheum2004，50，6： | 1 |
| 20 | Applicationof a reciprocity technique for measurement of acoustictransfer functions to the prediction of road vehiclepass-by noise显示文摘 | SHINICHI M JUNICHI A MASANORI F | 1997 | JSAE Review1997，，18： | 1 |
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