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| 1 | ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma显示文摘Sorafenib is the first-line treatment of advanced hepatocellular carcinoma(HCC).However,there is a lack of validated biomarkers to predict sorafenib sensitivity.In this study we investigated the role of ACSL4,a positive-activating enzyme of ferroptosis,in sorafenib-induced cell death and HCC patient outcome.We showed that ACSL4 protein expression was negatively associated with IC50 values of sorafenib in a panel of HCC cell lines(R=−0.952,P<0.001).Knockdown of ACSL4 expression by specific siRNA/sgRNA significantly attenuated sorafenib-induced lipid peroxidation and ferroptosis in Huh7 cells,and also rescued sorafenib-induced inhibition of xenograft tumor growth in vivo.We selected 29 HCC patients with surgery as primary treatment and sorafenib as postoperative adjunct therapy from a hospital-based cohort.A high proportion(66.7%)of HCC patients who had complete or partial responses to sorafenib treatment(according to the revised RECIST guideline)had higher ACSL4 expression in the pretreated HCC tissues,compared with those who had stable or progressed tumor growth(23.5%,P=0.029).Since ACSL4 expression was independent of sorafenib treatment,it could serve as a useful predictive biomarker.Taken together,this study demonstrates that ACSL4 is essential for sorafenib-induced ferroptosis and useful for predicting sorafenib sensitivity in HCC.This study may have important translational impacts in precise treatment of HCC. | Ji Feng Pei-zhi Lu Guang-zhi Zhu Shing Chung Hooi Yong Wu Xiao-wei Huang Hui-qi Dai Pan-hong Chen Zhong-jie Li Wen-jing Su Chuang-ye Han Xin-ping Ye Tao Peng Jing Zhou Guo-dong Lu | 2021 | Acta Pharmacologica Sinica2021，42，1： | 11 |
| 2 | The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells显示文摘 | Yi-Hong Hsin Chun-Feng Chen Shing Huang Tung-Sheng Shih Ping-Shan Lai Pin Ju Chueh | 2008 | Toxicology Letters2008，，3： | 2 |
| 3 | Rapid Canine retraction though distraction of the periodental ligament显示文摘 | Liou C Shing Huang | 1998 | Am J Orthod Dentofacial Orthop1998，114，： | 1 |
| 4 | Rapid Canine retraction through distraction of the periodental ligament 显示文摘 | Eric JW Liou Shing Huang | 1998 | Am J Orthod Dentofacial Orthop1998，114，： | 1 |
| 5 | Rapid canine retraction through distraction of the periodental ligament显示文摘 | Eric JW Liou Shing Huang C | 1998 | Am J Orthod Dentofacial Orthop1998，114，4： | 1 |
| 6 | Revisiting an ancient inorganic aggregation-induced emission system:An enlightenment to clusteroluminescence显示文摘Organic and inorganic clusteroluminescence have attracted great attention while the underlying mechanisms is still not well understood.Here,we employed a series of ancient inorganic complexes platinocyanides with aggregation-induced emission property to elucidate the mechanism of clusteroluminescence including how does the chromophore form and how does the solid structures influence the luminescence behaviors.The results indicate that the isolated platinocyanide cannot work as a chromophore to emit visible light,while their clusterization at aggregate state can trigger the d-orbitals coupling of the platinum atoms to facilitate the electron exchange and delocalization to form a new chromophore to emit visible light.Furthermore,the counter ions and H2O ligands help to rigidify the three-dimensional network structure of the platinocyanides to suppress the excited state nonradiative decay,resulting in the high quantum yield of up to 96%.This work fundamentally helps understanding both the organic and inorganic clusteroluminescence phenomenon. | Zheng Zhao Zaiyu Wang Javad Tavakoli Guogang Shan Jianyu Zhang Chen Peng Yu Xiong Xuepeng Zhang Tsz Shing Cheung Youhong Tang Bolong Huang Zhaoxun Yu Jacky W.Y.Lam Ben Zhong Tang | 2021 | Aggregate2021，2，2： | 1 |
| 7 | Hmnan Capital Distribution, Growth and Trade 显示文摘 | Cheng - Te Lee and Deng - Shing Huang | 2012 | Bulletin of Economic Research2012，，： | 1 |
| 8 | Rapid canine retraction through distraction of the periodontal ligament 显示文摘 | Eric J W Liou Shing Huang | 1998 | Am J Orthod Dentofacial Orthop1998，114，： | 1 |
| 9 | Heavy metals, islet function and diabetes development显示文摘 | Ya Wen Chen Ching Yao Yang Chun Fa Huang Dong Zong Hung Yuk Man Leung Shing Hwa Liu | 2009 | Islets2009，，3： | 1 |
| 10 | Maxillary growth of adult patients with unoperated cleft: answers to the debates Journal of Plastic 显示文摘 | Enrina Diah Lun -Jou Lo Chiung -Shing Huang | 2007 | Reconstructive & Aesthetic Surgery2007，60，4： | 1 |
| 11 | Disturbed mitotic progression and genome segregation are involved in cell transforma- tion mediated by nano-TiO2 long-term exposure显示文摘 | Huang Shing Chueh Pin-ju Lin Yun-wei | 2009 | Toxicol Appl Pharmaeol2009，241，2： | 1 |
| 12 | A Fuzzy Ontology and Its Application to News Summariza- tion显示文摘 | Chang - Shing Lee Zhi - Wei Jian Lin - Kai Huang | 2005 | IEEE Transaction on Systems Man and Cy- bernetics-Part B: Cybernetics2005，35，5： | 1 |
| 13 | The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitoehondrial pathway in NIH3T3 cells显示文摘 | Hsin YH Chen Chun-Feng Huang Shing | 2008 | Toxicol Lett2008，179，3： | 1 |
| 14 | Longitudinal Observation of Mandibular Motion Pattern in Patients With Skeletal Class III Malocclusion Subsequent to Orthognathic Surgery显示文摘 | Ellen Wen-Ching Ko Chiung Shing Huang Lun-Jou Lo Yu-Ray Chen | 2012 | Journal of Oral and Maxillofacial Surgery2012，，2： | 1 |
| 15 | The effectiveness of using procedural scaffoldings in a paper-plus-smart phone collaborative learning context显示文摘 | Huang Hui wen Wu Chih wei Chen Nian shing | 2012 | Computers&Education2012，，59： | 1 |
| 16 | Skeletal and Dental Variables Related to the Stability of Orthognathic Surgery in Skeletal Class III Malocclusion With a Surgery-First Approach显示文摘 | Ellen Wen-Ching Ko Shao Cheng Lin Yu Ray Chen Chiung Shing Huang | 2013 | Journal of Oral and Maxillofacial Surgery2013，，5： | 1 |
| 17 | Low - Complexity Spatial- Temporal Filtering Method via Compressive Sensing for Interference Mitigation in a GNSS Receiver显示文摘 | Chang Chung - Liang Huang Guo - Shing | 2014 | International Jour- nal of Antennas and Propagation2014，2014，： | 1 |
| 18 | Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF ‐κ B /microRNA 448 circuit显示文摘 | Ka‐Kit Mak Alexander T. H. Wu Wei‐Hwa Lee Tung‐Cheng Chang Jeng‐Fong Chiou Liang‐Shun Wang Chih‐Hsiung Wu Chi‐Ying F. Huang Yi‐Shing Shieh Tsu‐Yi Chao Chi‐Tang Ho Gow‐Chin Yen Chi‐Tai Yeh | 2013 | Mol Nutr Food Res2013，，7： | 1 |
| 19 | Echocardiographic evaluation of cardiac function in paediatric oncology patients treated with or without anthracycline显示文摘 | Sung RY Huang GY Shing MK | 1997 | Int J Cardiol1997，60，3： | 1 |
| 20 | High Microplastic Contamination in Juvenile Tri-Spine Horseshoe Crabs:A Baseline Study of Nursery Habitats in Northern Beibu Gulf,China显示文摘Microplastics(MPs)are ubiquitous in marine sedimentary environments.Their occurrence in horseshoe crabs and interactions with the sedimentary environment has not been determined.In this study,MPs,mostly microfibers,were found in all extracted gastrointestinal tract(GIT)samples of the juvenile Tachypleus tridentatus from the northern Beibu Gulf,China.The MP concentrations(4–53 items ind-1)were higher than those in most marine benthic invertebrates(<15 items ind-1)reported in Chinese waters,despite their generally low level in habitat sediments(9–1818 items kg-1).The correlation between the juveniles and sediments was not evident,but the abundance in juvenile horseshoe crab GITs decreased with ages.The findings were relevant to the life-history characteristics of the species,typically with limited dispersal capability and their spending nine years or longer time living in mangrove wetlands during low tides,with apparent ontogenetic changes in their diets.These baseline data enable a better understanding of MP availability in benthic macroinvertebrates,and the ecological risks present in the ecosystems. | WANG Xueping LO Hoi Shing FU Yijian WU Zhou QIN Danmei HUANG Xing ZHU Jingmin CHEUNG Siu Gin KWAN Kit Yue | 2022 | Journal of Ocean University of China2022，21，3： | 0 |
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