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| 1 | Bevacizumab as a second- or later-line of treatment for metastatic colorectal cancer显示文摘AIM: To determine the efficacy of bevacizumab in patients with metastatic colorectal cancer (MCRC) who have failed prior chemotherapy without bevacizumab. METHODS: Between March 2002 and June 2010, 40 patients in South Korea with MCRC who were treated with bevacizumab plus chemotherapy as a second or later-line treatment were analyzed retrospectively for their overall response rate (ORR), overall survival (OS), and progression-free survival (PFS). The tumor responses were assessed using the RECIST (Response Evaluation Criteria in Solid Tumors) guidelines. RESULTS: All of the patients had progressed under prior chemotherapy without bevacizumab. Three patients (7.5%) exhibited an ORR, twenty one patients (52.5%) exhibited stable disease (SD), and fifteen patients (37.5%) exhibited disease progression. The median duration of the OS and PFS were 14.0 and 6.13 mo respectively. The median OSs were 16.60, 14.07 and 13.00 mo for second-line, third-line and fourth- or later-line treatments, respectively. The median PFSs were 7.23, 7.30 and 3.87 mo for the second-line, third-line and fourth- or later-line treatments, respectively. CONCLUSION: In patients with MCRC, bevacizumab combined chemotherapy may be beneficial during second- or later-line treatment. | Lee Chun Park Ho Sup Lee Seong Hoon Shin Seun Ja Park Moo In Park Sung Yong Oh Hyuk Chan Kwon Jin ho Baek Young Jin Choi Myoung Joo Kang Yang Soo Kim | 2012 | World Journal of Gastroenterology2012，18，10： | 3 |
| 2 | Synergistic Memory Impairment Through the Interaction of Chronic Cerebral Hypoperfusion and Amlyloid Toxicity in a Rat Model显示文摘 | Bo-Ryoung Choi Sang Rim Lee Jung-Soo Han Sang-Keun Woo Kyeong Min Kim Dong-Hee Choi Kyoung Ja Kwon Seol-Heui Han Chan Young Shin Jongmin Lee Chin-Sang Chung Seong-Ryong Lee Hahn Young Kim | 2011 | Stroke2011，，9： | 2 |
| 3 | Effects of bamboo charcoal and bamboo vinegar as antibiotic alternatives on growth performance, immune responses and fecal microflora population in fattening pigs显示文摘 | Gyo Moon CHU Cheol Kyu JUNG Hoi Yun KIM Ji Hee HA Jong Hyun KIM Min Seob JUNG Shin Ja LEE Yuno SONG Rashid Ismael Hag IBRAHIM Jae Hyeon CHO Sung Sill LEE Young Min SONG | 2012 | Animal Science Journal2012，，2： | 2 |
| 4 | Large cell neuroendocrine carcinoma of the lung: radiologic and pathologic findings显示文摘 | Shin AR Shin BK Choi JA | 2000 | J Comput Assist Tomogra2000，24，4： | 2 |
| 5 | Markers for mapping by admixture linkage disequilibrium in African American and Hispanic populations显示文摘 | Smith MW Lautenberger JA Shin HD | 2001 | Am J Hum Genet2001，69，5： | 1 |
| 6 | Long-term filtration and visual field outcomes after primary glaucoma triple procedure with and without mitomycin-C显示文摘 | Shin DH Iskander NG Ahee JA | 2002 | Ophthalmology2002，109，9： | 1 |
| 7 | Retrospective analysis of peripheral blood stem cell transplantation for the treatment of high-risk neuroblastoma显示文摘 | Kim EK Kang HJ Park JA Choi HS Shin HY Ahn HS | 2007 | J Korean Med Sci2007，，： | 1 |
| 8 | Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease显示文摘 | Park JA Shin KS Kim YW | 2005 | J Korean Med Sci2005，20，4： | 1 |
| 9 | The Korean version of the Connor-Davidson Resilience Scale:An extended validation显示文摘 | Jung YE Min JA Shin AY etal | 2012 | Stress Health2012，28，4： | 1 |
| 10 | A cost- effective VLSI Architecture for Anisotropic Texture Filtering in Limitited Memory Bandwidth 显示文摘 | SHIN H C LEE JA KIM IS | 2006 | IEEE Transactions on very Large Scale Integration (VLSI) Sysstems2006，14，3： | 1 |
| 11 | Anti-inflammatory mechanism ofcompound k in activated microglia and its neuroprotective effect onexperimental stroke in mice 显示文摘 | Park JS Shin JA Jung JS | 2012 | J Pharmacol Exp Ther2012，341，1： | 1 |
| 12 | Radiotherapy plus eetuximab for squamous-eell carcinomaofthe head and neck 显示文摘 | Bonnet JA Harari PM Girah J Azarnia N Shin DM Cohen RB | 2006 | N Engl J Med2006，354，6： | 1 |
| 13 | APOE polymorphism and carotid atherosclerosis in a Korean population: the Dong-gu Study and the Namwon Study显示文摘 | Shin MH Choi JS Rhee JA | 2014 | Atherosclerosis2014，232，1： | 1 |
| 14 | Activation of estrogen receptor β reduces blood-brain barrier breakdown following ischemie injury 显示文摘 | Shin JA Yang S J Jeong SI | 2013 | Neuroscience2013，235，： | 1 |
| 15 | The association between chronic kidney disease and diabetic retinopathy: the Korea National Health and Nutrition Examination Survey 2008-2010显示文摘 | Park YH Shin JA Han JH | 2015 | PLoS One2015，10，01： | 1 |
| 16 | Dyspnea and panic among patients with newly diagnosed non-small cell lung cancer显示文摘 | Shin JA Kosiba JD Traeger L | 2014 | J Pain Symptom Manage2014，48，3： | 1 |
| 17 | Impact of grade,hormone receptor,and HER-2 status in women with breast cancer on response to specific chemotherapeutic agents by in vitro adenosine triphosphate-based chemotherapy response assay显示文摘 | Ja Seung Koo Woohee Jung Eunah Shin | 2009 | J Korean Med Sci2009，24，6： | 1 |
| 18 | Acute resveratrol treat- ment modulates multiple signaling pathways in the is- chemic brain 显示文摘 | Shin JA Leg KE Kim HS | 2012 | Neurochem Res2012，37，12： | 1 |
| 19 | CpG island hypermethylation and repetitive DNA hypomethylation in premalignant lesion of extrahepatic cholangiocarcinoma显示文摘 | Baek-hui Kim Nam-Yun Cho So Hyun Shin Hyeong-Ju Kwon Ja June Jang Gyeong Hoon Kang | 2009 | Virchows Archiv2009，，4： | 1 |
| 20 | The effect of parental transmission of diabetes on the development of gestational diabetes mellitus显示文摘 | Shin JA Yoon KH | 2010 | Korean J Intern Med2010，25，3： | 1 |
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